Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E/low density lipoprotein receptor and the N-acetyl-d-galactosamine/asialoglycoprotein receptor pathway

Lipid nanoparticles (LNPs) are one of the more promising technologies for efficiently delivering nucleic acids in vivo. Hepatocytes are the primary target cells of LNPs that are delivered via the apolipoprotein E (ApoE)-low density lipoprotein receptor (LDLR) pathway, an endogenous targeting pathway...

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Veröffentlicht in:	Journal of controlled release 2020-06, Vol.322, p.217-226
Hauptverfasser:	Sato, Yusuke, Kinami, Yoshiyuki, Hashiba, Kazuki, Harashima, Hideyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoprotein E Asialoglycoprotein receptor Heparansulfate proteoglycan Hepatic uptake Lipid nanoparticles Low density lipoprotein receptor N-acetyl-D-galactosamine
Online-Zugang:	Volltext
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