NAG‐thiazoline is a potent inhibitor of the Vibrio campbellii GH20 β‐N‐Acetylglucosaminidase

Vibrio spp. play a vital role in the recycling of chitin in oceans, but several Vibrio strains are highly infectious to aquatic animals and humans. These bacteria require chitin for growth; thus, potent inhibitors of chitin‐degrading enzymes could serve as candidate drugs against Vibrio infections....

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Veröffentlicht in:	The FEBS journal 2020-11, Vol.287 (22), p.4982-4995
Hauptverfasser:	Meekrathok, Piyanat, Stubbs, Keith A., Aunkham, Anuwat, Kaewmaneewat, Anuphon, Kardkuntod, Apinya, Bulmer, David M., Berg, Bert, Suginta, Wipa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials antimicrobial agent Antimicrobial agents Aquatic animals Bacteria Binding Chitin Data analysis Drug development Enthalpy GH‐20 β‐N‐acetylglucosaminidase Hydrogen bonds Hydrophobicity Infections NAG‐thiazoline Oceans Substrates Thiazoline Vibrio Vibrio campbellii Waterborne diseases
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