Epidemiological trend of hepatitis C-related liver events in Spain (2000–2015): A nationwide population-based study
•The real disease burden of Chronic hepatitis C (CHC) infection is underestimated.•Epidemiological trends of CHC infection and its clinical stages.•Provides a framework to evaluate future healthcare policies. Analysis the epidemiological trends of hospital admissions, intra-hospital deaths, and cost...
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| Veröffentlicht in: | European journal of internal medicine 2020-05, Vol.75, p.84-92 |
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| creator | Mate-Cano, Irene Alvaro-Meca, Alejandro Ryan, Pablo Resino, Salvador Briz, Verónica |
| description | •The real disease burden of Chronic hepatitis C (CHC) infection is underestimated.•Epidemiological trends of CHC infection and its clinical stages.•Provides a framework to evaluate future healthcare policies.
Analysis the epidemiological trends of hospital admissions, intra-hospital deaths, and costs related to chronic hepatitis C (CHC) taking into account four major clinical stages [compensated cirrhosis (CC), end-stage liver disease (ESLD), hepatocellular carcinoma (HCC), and liver transplantation (LT)] in Spain.
Retrospective study in patients with chronic hepatitis C and a hospital admission in the Spanish Minimum Basic Data Set from 2000 to 2015. Outcome variables were admission, death, length of hospital stay and costs.
A total of 868,523 hospital admissions with CHC (25.5% CC, 25.3% ESLD, 8.6% HCC, and 2.5% LT) were identified. Overall rates of admission and mortality increased from 2000–2003 to 2004–2007, but after 2008, these rates stabilized and/or decreased. An upward trend was found for hospitalization percentage in CC (from 22.3% to 30%; p |
| doi_str_mv | 10.1016/j.ejim.2020.02.002 |
| format | Article |
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Analysis the epidemiological trends of hospital admissions, intra-hospital deaths, and costs related to chronic hepatitis C (CHC) taking into account four major clinical stages [compensated cirrhosis (CC), end-stage liver disease (ESLD), hepatocellular carcinoma (HCC), and liver transplantation (LT)] in Spain.
Retrospective study in patients with chronic hepatitis C and a hospital admission in the Spanish Minimum Basic Data Set from 2000 to 2015. Outcome variables were admission, death, length of hospital stay and costs.
A total of 868,523 hospital admissions with CHC (25.5% CC, 25.3% ESLD, 8.6% HCC, and 2.5% LT) were identified. Overall rates of admission and mortality increased from 2000–2003 to 2004–2007, but after 2008, these rates stabilized and/or decreased. An upward trend was found for hospitalization percentage in CC (from 22.3% to 30%; p < 0.001), ESLD (from 23.9% to 27.1%; p < 0.001), HCC (from 7.4% to 11%; p < 0.001), and LT (from 0.07% to 0.10%; p = 0.003). An upward trend was also found for case fatality rate, except in ESLD (p = 0.944). Gender and age influenced the evolution of hospitalization rates and mortality differently. The length of hospital stay showed a significant downward trend in all strata analyzed (p < 0.001). Cost per patient had a significant upward trend (p < 0.001), except in LT, and a decrease from 2008–2011 to 2012–2015 in CC (p = 0.025), HCC (p < 0.001), and LT (p = 0.050) was found.
The initial upward trend of the disease burden in CHC has changed from 2000 to 2015 in Spain, improving in many parameters after 2004–2007, particularly in the 2012–2015 calendar period.]]></description><identifier>ISSN: 0953-6205</identifier><identifier>EISSN: 1879-0828</identifier><identifier>DOI: 10.1016/j.ejim.2020.02.002</identifier><identifier>PMID: 32143898</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Carcinoma, Hepatocellular - epidemiology ; Chronic hepatitis C ; Cirrhosis, hepatocarcinoma, liver transplantation ; End stage liver disease ; Hepatitis C ; Hepatitis C, Chronic - epidemiology ; Hospital admissions ; Humans ; ICD9CM codes ; Liver Cirrhosis - epidemiology ; Liver Neoplasms - epidemiology ; Mortality ; Retrospective Studies ; Spain - epidemiology</subject><ispartof>European journal of internal medicine, 2020-05, Vol.75, p.84-92</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-297f91f75fcde2f423b4edcddcc199a6b73b967e9a03f343b3425b2474c7a2f3</citedby><cites>FETCH-LOGICAL-c356t-297f91f75fcde2f423b4edcddcc199a6b73b967e9a03f343b3425b2474c7a2f3</cites><orcidid>0000-0003-2297-5098</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S095362052030039X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32143898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mate-Cano, Irene</creatorcontrib><creatorcontrib>Alvaro-Meca, Alejandro</creatorcontrib><creatorcontrib>Ryan, Pablo</creatorcontrib><creatorcontrib>Resino, Salvador</creatorcontrib><creatorcontrib>Briz, Verónica</creatorcontrib><title>Epidemiological trend of hepatitis C-related liver events in Spain (2000–2015): A nationwide population-based study</title><title>European journal of internal medicine</title><addtitle>Eur J Intern Med</addtitle><description><![CDATA[•The real disease burden of Chronic hepatitis C (CHC) infection is underestimated.•Epidemiological trends of CHC infection and its clinical stages.•Provides a framework to evaluate future healthcare policies.
Analysis the epidemiological trends of hospital admissions, intra-hospital deaths, and costs related to chronic hepatitis C (CHC) taking into account four major clinical stages [compensated cirrhosis (CC), end-stage liver disease (ESLD), hepatocellular carcinoma (HCC), and liver transplantation (LT)] in Spain.
Retrospective study in patients with chronic hepatitis C and a hospital admission in the Spanish Minimum Basic Data Set from 2000 to 2015. Outcome variables were admission, death, length of hospital stay and costs.
A total of 868,523 hospital admissions with CHC (25.5% CC, 25.3% ESLD, 8.6% HCC, and 2.5% LT) were identified. Overall rates of admission and mortality increased from 2000–2003 to 2004–2007, but after 2008, these rates stabilized and/or decreased. An upward trend was found for hospitalization percentage in CC (from 22.3% to 30%; p < 0.001), ESLD (from 23.9% to 27.1%; p < 0.001), HCC (from 7.4% to 11%; p < 0.001), and LT (from 0.07% to 0.10%; p = 0.003). An upward trend was also found for case fatality rate, except in ESLD (p = 0.944). Gender and age influenced the evolution of hospitalization rates and mortality differently. The length of hospital stay showed a significant downward trend in all strata analyzed (p < 0.001). Cost per patient had a significant upward trend (p < 0.001), except in LT, and a decrease from 2008–2011 to 2012–2015 in CC (p = 0.025), HCC (p < 0.001), and LT (p = 0.050) was found.
The initial upward trend of the disease burden in CHC has changed from 2000 to 2015 in Spain, improving in many parameters after 2004–2007, particularly in the 2012–2015 calendar period.]]></description><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Chronic hepatitis C</subject><subject>Cirrhosis, hepatocarcinoma, liver transplantation</subject><subject>End stage liver disease</subject><subject>Hepatitis C</subject><subject>Hepatitis C, Chronic - epidemiology</subject><subject>Hospital admissions</subject><subject>Humans</subject><subject>ICD9CM codes</subject><subject>Liver Cirrhosis - epidemiology</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Mortality</subject><subject>Retrospective Studies</subject><subject>Spain - epidemiology</subject><issn>0953-6205</issn><issn>1879-0828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtuFDEQRS0EIkPCD7BAXoZFd8p2d7uN2ESj8JAisUj2ltuuBo_6he2eKDv-gT_Ml8TDBJbZVKmke49Uh5B3DEoGrLnYlbjzY8mBQwm8BOAvyIa1UhXQ8vYl2YCqRdFwqE_Imxh3AEwCiNfkRHBWiVa1G7JeLd7h6Odh_uGtGWgKODk69_QnLib55CPdFgEHk9DRwe8xUNzjlCL1E71ZTJ7nHAAefv_hwOoPH-klnXJxnu4ymC7zsg5_z6IzMSNiWt39GXnVmyHi26d9Sm4_X91uvxbX3798215eF1bUTSq4kr1ivax765D3FRddhc46Zy1TyjSdFJ1qJCoDoheV6ETF645XsrLS8F6ckvMjdgnzrxVj0qOPFofBTDivUXMhK8FEtpKj_Bi1YY4xYK-X4EcT7jUDfbCtd_pgWx9sa-A6286l90_8tRvR_a_805sDn44BzE_uPQYdrcfJovMBbdJu9s_xHwEvVJFK</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Mate-Cano, Irene</creator><creator>Alvaro-Meca, Alejandro</creator><creator>Ryan, Pablo</creator><creator>Resino, Salvador</creator><creator>Briz, Verónica</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2297-5098</orcidid></search><sort><creationdate>202005</creationdate><title>Epidemiological trend of hepatitis C-related liver events in Spain (2000–2015): A nationwide population-based study</title><author>Mate-Cano, Irene ; Alvaro-Meca, Alejandro ; Ryan, Pablo ; Resino, Salvador ; Briz, Verónica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-297f91f75fcde2f423b4edcddcc199a6b73b967e9a03f343b3425b2474c7a2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Chronic hepatitis C</topic><topic>Cirrhosis, hepatocarcinoma, liver transplantation</topic><topic>End stage liver disease</topic><topic>Hepatitis C</topic><topic>Hepatitis C, Chronic - epidemiology</topic><topic>Hospital admissions</topic><topic>Humans</topic><topic>ICD9CM codes</topic><topic>Liver Cirrhosis - epidemiology</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Mortality</topic><topic>Retrospective Studies</topic><topic>Spain - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mate-Cano, Irene</creatorcontrib><creatorcontrib>Alvaro-Meca, Alejandro</creatorcontrib><creatorcontrib>Ryan, Pablo</creatorcontrib><creatorcontrib>Resino, Salvador</creatorcontrib><creatorcontrib>Briz, Verónica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mate-Cano, Irene</au><au>Alvaro-Meca, Alejandro</au><au>Ryan, Pablo</au><au>Resino, Salvador</au><au>Briz, Verónica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological trend of hepatitis C-related liver events in Spain (2000–2015): A nationwide population-based study</atitle><jtitle>European journal of internal medicine</jtitle><addtitle>Eur J Intern Med</addtitle><date>2020-05</date><risdate>2020</risdate><volume>75</volume><spage>84</spage><epage>92</epage><pages>84-92</pages><issn>0953-6205</issn><eissn>1879-0828</eissn><abstract><![CDATA[•The real disease burden of Chronic hepatitis C (CHC) infection is underestimated.•Epidemiological trends of CHC infection and its clinical stages.•Provides a framework to evaluate future healthcare policies.
Analysis the epidemiological trends of hospital admissions, intra-hospital deaths, and costs related to chronic hepatitis C (CHC) taking into account four major clinical stages [compensated cirrhosis (CC), end-stage liver disease (ESLD), hepatocellular carcinoma (HCC), and liver transplantation (LT)] in Spain.
Retrospective study in patients with chronic hepatitis C and a hospital admission in the Spanish Minimum Basic Data Set from 2000 to 2015. Outcome variables were admission, death, length of hospital stay and costs.
A total of 868,523 hospital admissions with CHC (25.5% CC, 25.3% ESLD, 8.6% HCC, and 2.5% LT) were identified. Overall rates of admission and mortality increased from 2000–2003 to 2004–2007, but after 2008, these rates stabilized and/or decreased. An upward trend was found for hospitalization percentage in CC (from 22.3% to 30%; p < 0.001), ESLD (from 23.9% to 27.1%; p < 0.001), HCC (from 7.4% to 11%; p < 0.001), and LT (from 0.07% to 0.10%; p = 0.003). An upward trend was also found for case fatality rate, except in ESLD (p = 0.944). Gender and age influenced the evolution of hospitalization rates and mortality differently. The length of hospital stay showed a significant downward trend in all strata analyzed (p < 0.001). Cost per patient had a significant upward trend (p < 0.001), except in LT, and a decrease from 2008–2011 to 2012–2015 in CC (p = 0.025), HCC (p < 0.001), and LT (p = 0.050) was found.
The initial upward trend of the disease burden in CHC has changed from 2000 to 2015 in Spain, improving in many parameters after 2004–2007, particularly in the 2012–2015 calendar period.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32143898</pmid><doi>10.1016/j.ejim.2020.02.002</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2297-5098</orcidid></addata></record> |
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| subjects | Carcinoma, Hepatocellular - epidemiology Chronic hepatitis C Cirrhosis, hepatocarcinoma, liver transplantation End stage liver disease Hepatitis C Hepatitis C, Chronic - epidemiology Hospital admissions Humans ICD9CM codes Liver Cirrhosis - epidemiology Liver Neoplasms - epidemiology Mortality Retrospective Studies Spain - epidemiology |
| title | Epidemiological trend of hepatitis C-related liver events in Spain (2000–2015): A nationwide population-based study |
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