A Physiologically Based in Silico Tool to Assess the Risk of Drug-Related Crystalluria

Drug precipitation in the nephrons of the kidney can cause drug-induced crystal nephropathy (DICN). To aid mitigation of this risk in early drug discovery, we developed a physiologically based in silico model to predict DICN in rats, dogs, and humans. At a minimum, the likelihood of DICN is determin...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-06, Vol.63 (12), p.6489-6498
Hauptverfasser:	Li, Zhenhong, Litchfield, John, Tess, David A, Carlo, Anthony A, Eng, Heather, Keefer, Christopher, Maurer, Tristan S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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