Low-Molecular-Weight Compound GSB-106 Mimics the Cellular Effects of BDNF after Serum Deprivation
The in vitro model of serum deprivation shows that the survival of SH-SY5Y neuronal cells is ensured by the intrinsic trophic activity of BDNF loop 4 mimetic GSB-106 (10 –7 М), which is comparable to that of endogenous neurotrophin (10 –9 М). The analysis of the cell cycle and S-phase showed that GS...
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| Veröffentlicht in: | Doklady. Biochemistry and biophysics 2019-11, Vol.489 (1), p.396-398 |
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| container_title | Doklady. Biochemistry and biophysics |
| container_volume | 489 |
| creator | Zainullina, L. F. Gudasheva, T. A. Vakhitova, Yu. V. Seredenin, S. B. |
| description | The in vitro model of serum deprivation shows that the survival of SH-SY5Y neuronal cells is ensured by the intrinsic trophic activity of BDNF loop 4 mimetic GSB-106 (10
–7
М), which is comparable to that of endogenous neurotrophin (10
–9
М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G
1
phase, diminishes the number of cells in the S-phase, reduces the number of apoptotic cells, and does not stimulate proliferation. |
| doi_str_mv | 10.1134/S1607672919060139 |
| format | Article |
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–7
М), which is comparable to that of endogenous neurotrophin (10
–9
М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G
1
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–7
М), which is comparable to that of endogenous neurotrophin (10
–9
М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G
1
phase, diminishes the number of cells in the S-phase, reduces the number of apoptotic cells, and does not stimulate proliferation.</description><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cell cycle</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cell Survival - drug effects</subject><subject>Dipeptides - chemistry</subject><subject>Dipeptides - pharmacology</subject><subject>G1 phase</subject><subject>G1 Phase Cell Cycle Checkpoints - drug effects</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Molecular Biology</subject><subject>Molecular Weight</subject><subject>Peptidomimetics - chemistry</subject><subject>Peptidomimetics - pharmacology</subject><subject>Serum - metabolism</subject><issn>1607-6729</issn><issn>1608-3091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtO5DAQRS3EiPcHsEGW2LAJ43IldnsJzWukBhY9I5aR49gQlMSNnYD4e9w0zEiMWLnkOvdW1SVkH9gxAOY_5yCYFJIrUEwwQLVGttLXJEOmYP29ltmyv0m2Y3xkjDOOxQbZRA6YFGqL6Jl_ya59a83Y6pDd2eb-YaBT3y382Nf0cn6aARP0uukaE-nwYOnUtu2SpefOWTNE6h09Pbu5oNoNNtC5DWNHz-wiNM96aHy_S3443Ua79_HukD8X57-nV9ns9vLX9GSWGZR8yGpURk5kIZzhKPJCAGphVeFcnQvjwKGGHA2rhKy1RFahlEpXPIfKGaEY7pCjle8i-KfRxqHsmmjSsrq3fowlRwmTIgdZJPTwC_rox9Cn7d4pkMiZSBSsKBN8jMG6Mt3U6fBaAiuX-Zf_5Z80Bx_OY9XZ-q_iM_AE8BUQU6u_t-Hf6O9d3wDpVYw9</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Zainullina, L. 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–7
М), which is comparable to that of endogenous neurotrophin (10
–9
М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G
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| ispartof | Doklady. Biochemistry and biophysics, 2019-11, Vol.489 (1), p.396-398 |
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| subjects | Apoptosis Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cell cycle Cell Line, Tumor Cell proliferation Cell Survival - drug effects Dipeptides - chemistry Dipeptides - pharmacology G1 phase G1 Phase Cell Cycle Checkpoints - drug effects Humans Life Sciences Molecular Biology Molecular Weight Peptidomimetics - chemistry Peptidomimetics - pharmacology Serum - metabolism |
| title | Low-Molecular-Weight Compound GSB-106 Mimics the Cellular Effects of BDNF after Serum Deprivation |
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