Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

Although it is well-established that reductions in the ratio of insulin to glucagon in the portal vein have a major role in the dysregulation of hepatic glucose metabolism in type-2 diabetes 1 – 3 , the mechanisms by which glucagon affects hepatic glucose production and mitochondrial oxidation are p...

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Veröffentlicht in:	Nature (London) 2020-03, Vol.579 (7798), p.279-283
Hauptverfasser:	Perry, Rachel J., Zhang, Dongyan, Guerra, Mateus T., Brill, Allison L., Goedeke, Leigh, Nasiri, Ali R., Rabin-Court, Aviva, Wang, Yongliang, Peng, Liang, Dufour, Sylvie, Zhang, Ye, Zhang, Xian-Man, Butrico, Gina M., Toussaint, Keshia, Nozaki, Yuichi, Cline, Gary W., Petersen, Kitt Falk, Nathanson, Michael H., Ehrlich, Barbara E., Shulman, Gerald I.
Format:	Artikel
Sprache:	eng
Schlagworte:	140/131 59 59/57 631/443/319/1642/2037 631/443/319/2723 631/443/319/333/1465 631/45/776/198 692/163/2743/137/773 Acetyl Coenzyme A - metabolism Adipose Tissue - drug effects Animals Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - physiopathology Enzyme Activation - drug effects Enzymes Fatty liver Glucagon Glucagon - blood Glucagon - pharmacology Gluconeogenesis Gluconeogenesis - drug effects Glucose Glucose metabolism Glucose tolerance Humanities and Social Sciences Inositol 1,4,5-trisphosphate receptors Inositol 1,4,5-Trisphosphate Receptors - genetics Inositol 1,4,5-Trisphosphate Receptors - metabolism Insulin Insulin resistance Intolerance Kinases Lipase Lipase - metabolism Lipids Lipolysis Lipolysis - drug effects Lipolysis - genetics Liver Liver - drug effects Liver diseases Mice, Knockout Mitochondria Mitochondria - drug effects multidisciplinary Non-alcoholic Fatty Liver Disease - physiopathology Observations Oxidation Oxidation-Reduction - drug effects Phosphorylation Physiological aspects Physiology Portal vein Proteins Pyruvate carboxylase Pyruvic acid Rodents Science Science (multidisciplinary) Steatosis Triglycerides Veins & arteries
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