Indomethacin decreases insulin secretion by reducing KCa3.1 as a biomarker of pancreatic tumor and causes apoptotic cell death

Insulinomas originate from pancreatic β cells and it is the most widely known tumor. Indomethacin is a nonsteroidal anti‐inflammatory drug, which is used for blocking the production of some natural substances that cause inflammation and decrease pain. In this study, I aimed to investigate the effect...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2020-07, Vol.34 (7), p.e22488-n/a
1. Verfasser:	Karatug Kacar, Ayse
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 2 AKT protein Animals Apoptosis Apoptosis - drug effects Beta cells Biomarkers Biomarkers, Tumor - metabolism Cell death Cell Line, Tumor Cell Survival - drug effects Cell viability Gene expression Glucose transporter Indomethacin Indomethacin - pharmacology Inflammation Insulin Insulin - biosynthesis Insulin secretion Insulin Secretion - drug effects Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulinoma Insulinoma - metabolism Insulinoma - pathology Insulinoma INS‐1 cells Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism Intracellular KCa3.1 Malondialdehyde MAP Kinase Signaling System - drug effects Metabolic pathways Metabolism Mortality Necrosis Neuroendocrine tumors Pain Pancreas Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Polymerase chain reaction Potassium channels (calcium-gated) Rats Receptors Reverse transcription Secretion Transcription factors Tumors
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