Long non-coding RNA MALAT1 as a key target in pathogenesis of glioblastoma. Janus faces or Achilles’ heal?

•LncRNAs (Long-noncoding RNAs) involve in versatile biological pathways.•LncRNA MALAT1 propagates growth of glioblastoma (GBM).•Opposite findings also exist regarding MALAT-1 functioning in GBM.•MALAT1 involves in stemness of GBM cells by regulating SOX2, nestin and WNT pathway.•MALAT1 deserves to b...

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Veröffentlicht in:	Gene 2020-05, Vol.739, p.144518-144518, Article 144518
Hauptverfasser:	Baspinar, Yucel, Elmaci, Ilhan, Ozpinar, Aysel, Altinoz, Meric A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - therapy Glioblastoma Glioblastoma - diagnosis Glioblastoma - genetics Glioblastoma - therapy Humans lncRNA MALAT1 microRNA MicroRNAs - genetics MicroRNAs - metabolism Nestin - genetics Nestin - metabolism Prognosis RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Wnt Signaling Pathway - genetics
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