Molecular Design of Highly Efficient Heavy‐Atom‐Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging

Novel BODIPY photosensitizers were developed for imaging‐guided photodynamic therapy. The introduction of a strong electron donor to the BODIPY core through a phenyl linker combined with the twisted arrangement between the donor and the BODIPY acceptor is essential for reducing the energy gap betwee...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-06, Vol.59 (23), p.8957-8962
Hauptverfasser:	Nguyen, Van‐Nghia, Yim, Yubin, Kim, Sangin, Ryu, Bokyeong, Swamy, K. M. K., Kim, Gyoungmi, Kwon, Nahyun, Kim, C‐Yoon, Park, Sungnam, Yoon, Juyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation-induced emission Aqueous solutions Atomic energy levels BODIPY Boron Compounds - chemistry Boron Compounds - pharmacology Boron Compounds - therapeutic use Cell Line, Tumor Chemistry Chemistry, Multidisciplinary Drug Design Energy gap heavy-atom-free photosensitizers Humans In vivo methods and tests Medical imaging Molecular Imaging - methods Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Physical Sciences reactive oxygen species Science & Technology Singlet oxygen Triplet state
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