Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients
Background The interaction between T-cells/fatty acids involved in non-alcoholic fatty liver disease (NAFLD) and liver fibrosis progression is poorly understood. In this study, we conducted a comprehensive analysis of T-cell profiles of NAFLD patients to better understand their relationship with fat...
Gespeichert in:
| Veröffentlicht in: | Journal of gastroenterology 2020-07, Vol.55 (7), p.701-711 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 711 |
|---|---|
| container_issue | 7 |
| container_start_page | 701 |
| container_title | Journal of gastroenterology |
| container_volume | 55 |
| creator | Seike, Takuya Mizukoshi, Eishiro Yamada, Kazutoshi Okada, Hikari Kitahara, Masaaki Yamashita, Tatsuya Arai, Kuniaki Terashima, Takeshi Iida, Noriho Fushimi, Kazumi Yamashita, Taro Sakai, Yoshio Honda, Masao Harada, Kenichi Kaneko, Shuichi |
| description | Background
The interaction between T-cells/fatty acids involved in non-alcoholic fatty liver disease (NAFLD) and liver fibrosis progression is poorly understood. In this study, we conducted a comprehensive analysis of T-cell profiles of NAFLD patients to better understand their relationship with fatty acids and relevance to liver fibrosis.
Methods
We analyzed the differences in T-cell profiles of peripheral blood mononuclear cells (PBMCs) between 40 NAFLD patients and 5 healthy volunteers (HVs), and their relationship with liver fibrosis stage or progression. Moreover, we analyzed the relationship between T-cell profiles and fatty acid compositions in vivo, and changes in T-cell profiles after treatment with fatty acids in vitro.
Results
T-cell profiles of NAFLD patients were different from those of HVs. The CD25
+
CD45
+
CD4
+
T-cell frequency was increased in NAFLD patients with high liver fibrosis stage and progression, and this indicated immune activation. Despite such a state of immune activation, the PD1
+
CD4
+
T-cell frequency was decreased in the same patients group. The PD1
+
CD4
+
T-cell frequency had a significantly negative correlation with the serum fatty acid composition ratio C16:1n7/C16:0. Moreover, the PD1
+
CD4
+
T-cell frequency was significantly decreased by in vitro treatment with fatty acids. In addition, its rate of frequency change was significantly different between C16:0 and C16:1n7 and decreased by artificially increasing the C16:1n7/C16:0 ratio.
Conclusions
The analysis of PBMCs in NAFLD patients showed that T-cell profiles were different from those of HVs. And, it suggested that fatty acids modified T-cell profiles and were involved in liver fibrosis in NAFLD patients. |
| doi_str_mv | 10.1007/s00535-020-01679-7 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2370530968</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714582884</galeid><sourcerecordid>A714582884</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-1fac7909f18e3d46a727e598b1815055f2c2f58ecf3acae9a569a34d8ce91efa3</originalsourceid><addsrcrecordid>eNp9kU9rVDEUxYModqx-ARfywI2b1Jt_L8myFFuFgpu6jmneTU15k4zJG6HfvpmZ1qKIZBG4-Z3DyT2EvGVwwgD0xwaghKLAgQIbtaX6GVkx2UfKcv6crMBKSRnT8oi8au0WgAlQ5iU5EpxxCYatyPdzvyx3gw9polNNvzAP6zKlmIJfUsltSHm4ogHnedjUEtOM-1Eumfo5lB9lTmGIe4-5q-swpYa-4bDpesxLe01eRD83fPNwH5Nv55-uzj7Ty68XX85OL2mQ47hQFn3QFmxkBsUkR6-5RmXNNTNMgVKRBx6VwRCFDx6tV6P1Qk4moGUYvTgmHw6-PebPLbbFrVPb5fYZy7Y5LnTfFtjRdPT9X-ht2dbc0zkumTDcgJFP1I2f0aUcy1J92Jm6U82k6tieOvkH1c-E6xRKxt3K_hTwgyDU0lrF6DY1rX29cwzcrlZ3qNX1Wt2-Vqe76N1D4u31GqffksceOyAOQOtP-Qbr05f-Y3sP4dasFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2413828084</pqid></control><display><type>article</type><title>Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients</title><source>Springer Nature - Complete Springer Journals</source><creator>Seike, Takuya ; Mizukoshi, Eishiro ; Yamada, Kazutoshi ; Okada, Hikari ; Kitahara, Masaaki ; Yamashita, Tatsuya ; Arai, Kuniaki ; Terashima, Takeshi ; Iida, Noriho ; Fushimi, Kazumi ; Yamashita, Taro ; Sakai, Yoshio ; Honda, Masao ; Harada, Kenichi ; Kaneko, Shuichi</creator><creatorcontrib>Seike, Takuya ; Mizukoshi, Eishiro ; Yamada, Kazutoshi ; Okada, Hikari ; Kitahara, Masaaki ; Yamashita, Tatsuya ; Arai, Kuniaki ; Terashima, Takeshi ; Iida, Noriho ; Fushimi, Kazumi ; Yamashita, Taro ; Sakai, Yoshio ; Honda, Masao ; Harada, Kenichi ; Kaneko, Shuichi</creatorcontrib><description>Background
The interaction between T-cells/fatty acids involved in non-alcoholic fatty liver disease (NAFLD) and liver fibrosis progression is poorly understood. In this study, we conducted a comprehensive analysis of T-cell profiles of NAFLD patients to better understand their relationship with fatty acids and relevance to liver fibrosis.
Methods
We analyzed the differences in T-cell profiles of peripheral blood mononuclear cells (PBMCs) between 40 NAFLD patients and 5 healthy volunteers (HVs), and their relationship with liver fibrosis stage or progression. Moreover, we analyzed the relationship between T-cell profiles and fatty acid compositions in vivo, and changes in T-cell profiles after treatment with fatty acids in vitro.
Results
T-cell profiles of NAFLD patients were different from those of HVs. The CD25
+
CD45
+
CD4
+
T-cell frequency was increased in NAFLD patients with high liver fibrosis stage and progression, and this indicated immune activation. Despite such a state of immune activation, the PD1
+
CD4
+
T-cell frequency was decreased in the same patients group. The PD1
+
CD4
+
T-cell frequency had a significantly negative correlation with the serum fatty acid composition ratio C16:1n7/C16:0. Moreover, the PD1
+
CD4
+
T-cell frequency was significantly decreased by in vitro treatment with fatty acids. In addition, its rate of frequency change was significantly different between C16:0 and C16:1n7 and decreased by artificially increasing the C16:1n7/C16:0 ratio.
Conclusions
The analysis of PBMCs in NAFLD patients showed that T-cell profiles were different from those of HVs. And, it suggested that fatty acids modified T-cell profiles and were involved in liver fibrosis in NAFLD patients.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-020-01679-7</identifier><identifier>PMID: 32124081</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Abdominal Surgery ; Analysis ; Antiretroviral drugs ; Biliary Tract ; CD25 antigen ; CD4 antigen ; CD45 antigen ; Colorectal Surgery ; Fatty acid composition ; Fatty acids ; Fatty liver ; Fibrosis ; Gastroenterology ; Hepatology ; Immune response ; Leukocytes (mononuclear) ; Liver diseases ; Lymphocytes T ; Medicine ; Medicine & Public Health ; Original Article—Liver ; Pancreas ; PD-1 protein ; Peripheral blood mononuclear cells ; Surgical Oncology ; T cells</subject><ispartof>Journal of gastroenterology, 2020-07, Vol.55 (7), p.701-711</ispartof><rights>Japanese Society of Gastroenterology 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Japanese Society of Gastroenterology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-1fac7909f18e3d46a727e598b1815055f2c2f58ecf3acae9a569a34d8ce91efa3</citedby><cites>FETCH-LOGICAL-c466t-1fac7909f18e3d46a727e598b1815055f2c2f58ecf3acae9a569a34d8ce91efa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-020-01679-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-020-01679-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32124081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seike, Takuya</creatorcontrib><creatorcontrib>Mizukoshi, Eishiro</creatorcontrib><creatorcontrib>Yamada, Kazutoshi</creatorcontrib><creatorcontrib>Okada, Hikari</creatorcontrib><creatorcontrib>Kitahara, Masaaki</creatorcontrib><creatorcontrib>Yamashita, Tatsuya</creatorcontrib><creatorcontrib>Arai, Kuniaki</creatorcontrib><creatorcontrib>Terashima, Takeshi</creatorcontrib><creatorcontrib>Iida, Noriho</creatorcontrib><creatorcontrib>Fushimi, Kazumi</creatorcontrib><creatorcontrib>Yamashita, Taro</creatorcontrib><creatorcontrib>Sakai, Yoshio</creatorcontrib><creatorcontrib>Honda, Masao</creatorcontrib><creatorcontrib>Harada, Kenichi</creatorcontrib><creatorcontrib>Kaneko, Shuichi</creatorcontrib><title>Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
The interaction between T-cells/fatty acids involved in non-alcoholic fatty liver disease (NAFLD) and liver fibrosis progression is poorly understood. In this study, we conducted a comprehensive analysis of T-cell profiles of NAFLD patients to better understand their relationship with fatty acids and relevance to liver fibrosis.
Methods
We analyzed the differences in T-cell profiles of peripheral blood mononuclear cells (PBMCs) between 40 NAFLD patients and 5 healthy volunteers (HVs), and their relationship with liver fibrosis stage or progression. Moreover, we analyzed the relationship between T-cell profiles and fatty acid compositions in vivo, and changes in T-cell profiles after treatment with fatty acids in vitro.
Results
T-cell profiles of NAFLD patients were different from those of HVs. The CD25
+
CD45
+
CD4
+
T-cell frequency was increased in NAFLD patients with high liver fibrosis stage and progression, and this indicated immune activation. Despite such a state of immune activation, the PD1
+
CD4
+
T-cell frequency was decreased in the same patients group. The PD1
+
CD4
+
T-cell frequency had a significantly negative correlation with the serum fatty acid composition ratio C16:1n7/C16:0. Moreover, the PD1
+
CD4
+
T-cell frequency was significantly decreased by in vitro treatment with fatty acids. In addition, its rate of frequency change was significantly different between C16:0 and C16:1n7 and decreased by artificially increasing the C16:1n7/C16:0 ratio.
Conclusions
The analysis of PBMCs in NAFLD patients showed that T-cell profiles were different from those of HVs. And, it suggested that fatty acids modified T-cell profiles and were involved in liver fibrosis in NAFLD patients.</description><subject>Abdominal Surgery</subject><subject>Analysis</subject><subject>Antiretroviral drugs</subject><subject>Biliary Tract</subject><subject>CD25 antigen</subject><subject>CD4 antigen</subject><subject>CD45 antigen</subject><subject>Colorectal Surgery</subject><subject>Fatty acid composition</subject><subject>Fatty acids</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Immune response</subject><subject>Leukocytes (mononuclear)</subject><subject>Liver diseases</subject><subject>Lymphocytes T</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article—Liver</subject><subject>Pancreas</subject><subject>PD-1 protein</subject><subject>Peripheral blood mononuclear cells</subject><subject>Surgical Oncology</subject><subject>T cells</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kU9rVDEUxYModqx-ARfywI2b1Jt_L8myFFuFgpu6jmneTU15k4zJG6HfvpmZ1qKIZBG4-Z3DyT2EvGVwwgD0xwaghKLAgQIbtaX6GVkx2UfKcv6crMBKSRnT8oi8au0WgAlQ5iU5EpxxCYatyPdzvyx3gw9polNNvzAP6zKlmIJfUsltSHm4ogHnedjUEtOM-1Eumfo5lB9lTmGIe4-5q-swpYa-4bDpesxLe01eRD83fPNwH5Nv55-uzj7Ty68XX85OL2mQ47hQFn3QFmxkBsUkR6-5RmXNNTNMgVKRBx6VwRCFDx6tV6P1Qk4moGUYvTgmHw6-PebPLbbFrVPb5fYZy7Y5LnTfFtjRdPT9X-ht2dbc0zkumTDcgJFP1I2f0aUcy1J92Jm6U82k6tieOvkH1c-E6xRKxt3K_hTwgyDU0lrF6DY1rX29cwzcrlZ3qNX1Wt2-Vqe76N1D4u31GqffksceOyAOQOtP-Qbr05f-Y3sP4dasFA</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Seike, Takuya</creator><creator>Mizukoshi, Eishiro</creator><creator>Yamada, Kazutoshi</creator><creator>Okada, Hikari</creator><creator>Kitahara, Masaaki</creator><creator>Yamashita, Tatsuya</creator><creator>Arai, Kuniaki</creator><creator>Terashima, Takeshi</creator><creator>Iida, Noriho</creator><creator>Fushimi, Kazumi</creator><creator>Yamashita, Taro</creator><creator>Sakai, Yoshio</creator><creator>Honda, Masao</creator><creator>Harada, Kenichi</creator><creator>Kaneko, Shuichi</creator><general>Springer Singapore</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200701</creationdate><title>Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients</title><author>Seike, Takuya ; Mizukoshi, Eishiro ; Yamada, Kazutoshi ; Okada, Hikari ; Kitahara, Masaaki ; Yamashita, Tatsuya ; Arai, Kuniaki ; Terashima, Takeshi ; Iida, Noriho ; Fushimi, Kazumi ; Yamashita, Taro ; Sakai, Yoshio ; Honda, Masao ; Harada, Kenichi ; Kaneko, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-1fac7909f18e3d46a727e598b1815055f2c2f58ecf3acae9a569a34d8ce91efa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdominal Surgery</topic><topic>Analysis</topic><topic>Antiretroviral drugs</topic><topic>Biliary Tract</topic><topic>CD25 antigen</topic><topic>CD4 antigen</topic><topic>CD45 antigen</topic><topic>Colorectal Surgery</topic><topic>Fatty acid composition</topic><topic>Fatty acids</topic><topic>Fatty liver</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Immune response</topic><topic>Leukocytes (mononuclear)</topic><topic>Liver diseases</topic><topic>Lymphocytes T</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article—Liver</topic><topic>Pancreas</topic><topic>PD-1 protein</topic><topic>Peripheral blood mononuclear cells</topic><topic>Surgical Oncology</topic><topic>T cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seike, Takuya</creatorcontrib><creatorcontrib>Mizukoshi, Eishiro</creatorcontrib><creatorcontrib>Yamada, Kazutoshi</creatorcontrib><creatorcontrib>Okada, Hikari</creatorcontrib><creatorcontrib>Kitahara, Masaaki</creatorcontrib><creatorcontrib>Yamashita, Tatsuya</creatorcontrib><creatorcontrib>Arai, Kuniaki</creatorcontrib><creatorcontrib>Terashima, Takeshi</creatorcontrib><creatorcontrib>Iida, Noriho</creatorcontrib><creatorcontrib>Fushimi, Kazumi</creatorcontrib><creatorcontrib>Yamashita, Taro</creatorcontrib><creatorcontrib>Sakai, Yoshio</creatorcontrib><creatorcontrib>Honda, Masao</creatorcontrib><creatorcontrib>Harada, Kenichi</creatorcontrib><creatorcontrib>Kaneko, Shuichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seike, Takuya</au><au>Mizukoshi, Eishiro</au><au>Yamada, Kazutoshi</au><au>Okada, Hikari</au><au>Kitahara, Masaaki</au><au>Yamashita, Tatsuya</au><au>Arai, Kuniaki</au><au>Terashima, Takeshi</au><au>Iida, Noriho</au><au>Fushimi, Kazumi</au><au>Yamashita, Taro</au><au>Sakai, Yoshio</au><au>Honda, Masao</au><au>Harada, Kenichi</au><au>Kaneko, Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>55</volume><issue>7</issue><spage>701</spage><epage>711</epage><pages>701-711</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
The interaction between T-cells/fatty acids involved in non-alcoholic fatty liver disease (NAFLD) and liver fibrosis progression is poorly understood. In this study, we conducted a comprehensive analysis of T-cell profiles of NAFLD patients to better understand their relationship with fatty acids and relevance to liver fibrosis.
Methods
We analyzed the differences in T-cell profiles of peripheral blood mononuclear cells (PBMCs) between 40 NAFLD patients and 5 healthy volunteers (HVs), and their relationship with liver fibrosis stage or progression. Moreover, we analyzed the relationship between T-cell profiles and fatty acid compositions in vivo, and changes in T-cell profiles after treatment with fatty acids in vitro.
Results
T-cell profiles of NAFLD patients were different from those of HVs. The CD25
+
CD45
+
CD4
+
T-cell frequency was increased in NAFLD patients with high liver fibrosis stage and progression, and this indicated immune activation. Despite such a state of immune activation, the PD1
+
CD4
+
T-cell frequency was decreased in the same patients group. The PD1
+
CD4
+
T-cell frequency had a significantly negative correlation with the serum fatty acid composition ratio C16:1n7/C16:0. Moreover, the PD1
+
CD4
+
T-cell frequency was significantly decreased by in vitro treatment with fatty acids. In addition, its rate of frequency change was significantly different between C16:0 and C16:1n7 and decreased by artificially increasing the C16:1n7/C16:0 ratio.
Conclusions
The analysis of PBMCs in NAFLD patients showed that T-cell profiles were different from those of HVs. And, it suggested that fatty acids modified T-cell profiles and were involved in liver fibrosis in NAFLD patients.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32124081</pmid><doi>10.1007/s00535-020-01679-7</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2020-07, Vol.55 (7), p.701-711 |
| issn | 0944-1174 1435-5922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2370530968 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Analysis Antiretroviral drugs Biliary Tract CD25 antigen CD4 antigen CD45 antigen Colorectal Surgery Fatty acid composition Fatty acids Fatty liver Fibrosis Gastroenterology Hepatology Immune response Leukocytes (mononuclear) Liver diseases Lymphocytes T Medicine Medicine & Public Health Original Article—Liver Pancreas PD-1 protein Peripheral blood mononuclear cells Surgical Oncology T cells |
| title | Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T22%3A47%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fatty%20acid-driven%20modifications%20in%20T-cell%20profiles%20in%20non-alcoholic%20fatty%20liver%20disease%20patients&rft.jtitle=Journal%20of%20gastroenterology&rft.au=Seike,%20Takuya&rft.date=2020-07-01&rft.volume=55&rft.issue=7&rft.spage=701&rft.epage=711&rft.pages=701-711&rft.issn=0944-1174&rft.eissn=1435-5922&rft_id=info:doi/10.1007/s00535-020-01679-7&rft_dat=%3Cgale_proqu%3EA714582884%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2413828084&rft_id=info:pmid/32124081&rft_galeid=A714582884&rfr_iscdi=true |