Factors influencing platelet normalization of transient abnormal myelopoiesis
Background Abnormal blood cell counts are characteristic of patients with Down syndrome and transient abnormal myelopoiesis (TAM). Although some patients with TAM experience prolonged anemia or thrombocytopenia, hematological factors predicting blood cell count recovery have not been reported yet. T...
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| Veröffentlicht in: | Pediatrics international 2020-08, Vol.62 (8), p.907-910 |
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| creator | Nakamura, Wataru Goto, Hiroaki Hayashi, Akiko Keino, Dai Sugiyama, Masanaka Miyagawa, Naoyuki Iwasaki, Fuminori Hamanoue, Satoshi Yokosuka, Tomoko Goto, Shoko Toyoshima, Katsuaki |
| description | Background
Abnormal blood cell counts are characteristic of patients with Down syndrome and transient abnormal myelopoiesis (TAM). Although some patients with TAM experience prolonged anemia or thrombocytopenia, hematological factors predicting blood cell count recovery have not been reported yet. The aim of this study was to investigate the factors influencing platelet normalization in TAM.
Methods
A retrospective review of the medical records of 21 patients with TAM admitted to the neonatal intensive care unit at Kanagawa Children’s Medical Center between January 2007 and October 2014 was undertaken.
Results
In the 16 of 21 patients (76%) experiencing transient thrombocytopenia, a large number of blasts at diagnosis was found to be significantly associated with late platelet recovery (R = 0.669, P < 0.05), and higher platelet counts at diagnosis were significantly associated with later recovery (R = 0.719, P < 0.01). Indeed, a strong positive correlation between blast and platelet counts at diagnosis was found (R = 0.730, P < 0.01).
Conclusions
Our data suggest that high platelet counts at TAM diagnosis might reflect abnormal thrombocyte production from blasts. Thus, physicians should be aware of the possibility of prolonged thrombocytopenia in patients with TAM who exhibit a high platelet and/or blast count at diagnosis. |
| doi_str_mv | 10.1111/ped.14214 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2370530477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2370530477</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4434-9114c6104088a509d528a728a726b8278b809b4e223b0a3fa9e5d81e91f87ded3</originalsourceid><addsrcrecordid>eNp1kE1r3DAQhkVp6CZpD_0DxdBLc3Ay-vBKPpZ8Q0JyaKE3IdvjokWWXMkmbH59lfXmEohg0DDz8DI8hHylcErzOxuxO6WCUfGBHFIhWMkA_nzMPWeqVLCWK3KU0gYAlFTiE1lxRpmogB2S-yvTTiGmwvrezehb6_8WozMTOpwKH-JgnH02kw2-CH0xReOTRT8VplmWxbBFF8ZgMdn0mRz0xiX8sv-Pye-ry1_nN-Xdw_Xt-c-7shWCi7KmVLRrCgKUMhXUXcWUkbtaN4pJ1SioG4GM8QYM702NVaco1rRXssOOH5MfS-4Yw78Z06QHm1p0zngMc9KMS6g4CCkz-v0Nuglz9Pk6zQSX2QTUIlMnC9XGkFLEXo_RDiZuNQX94lhnx3rnOLPf9olzM-TpK_kqNQNnC_BkHW7fT9KPlxdL5H-psITg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2437321094</pqid></control><display><type>article</type><title>Factors influencing platelet normalization of transient abnormal myelopoiesis</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Nakamura, Wataru ; Goto, Hiroaki ; Hayashi, Akiko ; Keino, Dai ; Sugiyama, Masanaka ; Miyagawa, Naoyuki ; Iwasaki, Fuminori ; Hamanoue, Satoshi ; Yokosuka, Tomoko ; Goto, Shoko ; Toyoshima, Katsuaki</creator><creatorcontrib>Nakamura, Wataru ; Goto, Hiroaki ; Hayashi, Akiko ; Keino, Dai ; Sugiyama, Masanaka ; Miyagawa, Naoyuki ; Iwasaki, Fuminori ; Hamanoue, Satoshi ; Yokosuka, Tomoko ; Goto, Shoko ; Toyoshima, Katsuaki</creatorcontrib><description>Background
Abnormal blood cell counts are characteristic of patients with Down syndrome and transient abnormal myelopoiesis (TAM). Although some patients with TAM experience prolonged anemia or thrombocytopenia, hematological factors predicting blood cell count recovery have not been reported yet. The aim of this study was to investigate the factors influencing platelet normalization in TAM.
Methods
A retrospective review of the medical records of 21 patients with TAM admitted to the neonatal intensive care unit at Kanagawa Children’s Medical Center between January 2007 and October 2014 was undertaken.
Results
In the 16 of 21 patients (76%) experiencing transient thrombocytopenia, a large number of blasts at diagnosis was found to be significantly associated with late platelet recovery (R = 0.669, P < 0.05), and higher platelet counts at diagnosis were significantly associated with later recovery (R = 0.719, P < 0.01). Indeed, a strong positive correlation between blast and platelet counts at diagnosis was found (R = 0.730, P < 0.01).
Conclusions
Our data suggest that high platelet counts at TAM diagnosis might reflect abnormal thrombocyte production from blasts. Thus, physicians should be aware of the possibility of prolonged thrombocytopenia in patients with TAM who exhibit a high platelet and/or blast count at diagnosis.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.14214</identifier><identifier>PMID: 32124502</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Blast ; Blood Cell Count ; Blood platelets ; Blood Platelets - metabolism ; Diagnosis ; Down syndrome ; Down Syndrome - blood ; Down Syndrome - complications ; Down Syndrome - diagnosis ; Down's syndrome ; Female ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Neonatal ; Leukemoid Reaction - blood ; Leukemoid Reaction - complications ; Leukemoid Reaction - diagnosis ; Male ; Medical records ; Myelopoiesis ; Neonates ; Pediatrics ; Platelet Count - methods ; Platelets ; Retrospective Studies ; Thrombocytopenia ; Thrombocytopenia - complications ; transient abnormal myelopoiesis</subject><ispartof>Pediatrics international, 2020-08, Vol.62 (8), p.907-910</ispartof><rights>2020 Japan Pediatric Society</rights><rights>2020 Japan Pediatric Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4434-9114c6104088a509d528a728a726b8278b809b4e223b0a3fa9e5d81e91f87ded3</citedby><cites>FETCH-LOGICAL-c4434-9114c6104088a509d528a728a726b8278b809b4e223b0a3fa9e5d81e91f87ded3</cites><orcidid>0000-0001-5889-2628 ; 0000-0003-0691-0331 ; 0000-0002-0760-9498</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.14214$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.14214$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32124502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Wataru</creatorcontrib><creatorcontrib>Goto, Hiroaki</creatorcontrib><creatorcontrib>Hayashi, Akiko</creatorcontrib><creatorcontrib>Keino, Dai</creatorcontrib><creatorcontrib>Sugiyama, Masanaka</creatorcontrib><creatorcontrib>Miyagawa, Naoyuki</creatorcontrib><creatorcontrib>Iwasaki, Fuminori</creatorcontrib><creatorcontrib>Hamanoue, Satoshi</creatorcontrib><creatorcontrib>Yokosuka, Tomoko</creatorcontrib><creatorcontrib>Goto, Shoko</creatorcontrib><creatorcontrib>Toyoshima, Katsuaki</creatorcontrib><title>Factors influencing platelet normalization of transient abnormal myelopoiesis</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background
Abnormal blood cell counts are characteristic of patients with Down syndrome and transient abnormal myelopoiesis (TAM). Although some patients with TAM experience prolonged anemia or thrombocytopenia, hematological factors predicting blood cell count recovery have not been reported yet. The aim of this study was to investigate the factors influencing platelet normalization in TAM.
Methods
A retrospective review of the medical records of 21 patients with TAM admitted to the neonatal intensive care unit at Kanagawa Children’s Medical Center between January 2007 and October 2014 was undertaken.
Results
In the 16 of 21 patients (76%) experiencing transient thrombocytopenia, a large number of blasts at diagnosis was found to be significantly associated with late platelet recovery (R = 0.669, P < 0.05), and higher platelet counts at diagnosis were significantly associated with later recovery (R = 0.719, P < 0.01). Indeed, a strong positive correlation between blast and platelet counts at diagnosis was found (R = 0.730, P < 0.01).
Conclusions
Our data suggest that high platelet counts at TAM diagnosis might reflect abnormal thrombocyte production from blasts. Thus, physicians should be aware of the possibility of prolonged thrombocytopenia in patients with TAM who exhibit a high platelet and/or blast count at diagnosis.</description><subject>Blast</subject><subject>Blood Cell Count</subject><subject>Blood platelets</subject><subject>Blood Platelets - metabolism</subject><subject>Diagnosis</subject><subject>Down syndrome</subject><subject>Down Syndrome - blood</subject><subject>Down Syndrome - complications</subject><subject>Down Syndrome - diagnosis</subject><subject>Down's syndrome</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intensive Care Units, Neonatal</subject><subject>Leukemoid Reaction - blood</subject><subject>Leukemoid Reaction - complications</subject><subject>Leukemoid Reaction - diagnosis</subject><subject>Male</subject><subject>Medical records</subject><subject>Myelopoiesis</subject><subject>Neonates</subject><subject>Pediatrics</subject><subject>Platelet Count - methods</subject><subject>Platelets</subject><subject>Retrospective Studies</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - complications</subject><subject>transient abnormal myelopoiesis</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVp6CZpD_0DxdBLc3Ay-vBKPpZ8Q0JyaKE3IdvjokWWXMkmbH59lfXmEohg0DDz8DI8hHylcErzOxuxO6WCUfGBHFIhWMkA_nzMPWeqVLCWK3KU0gYAlFTiE1lxRpmogB2S-yvTTiGmwvrezehb6_8WozMTOpwKH-JgnH02kw2-CH0xReOTRT8VplmWxbBFF8ZgMdn0mRz0xiX8sv-Pye-ry1_nN-Xdw_Xt-c-7shWCi7KmVLRrCgKUMhXUXcWUkbtaN4pJ1SioG4GM8QYM702NVaco1rRXssOOH5MfS-4Yw78Z06QHm1p0zngMc9KMS6g4CCkz-v0Nuglz9Pk6zQSX2QTUIlMnC9XGkFLEXo_RDiZuNQX94lhnx3rnOLPf9olzM-TpK_kqNQNnC_BkHW7fT9KPlxdL5H-psITg</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Nakamura, Wataru</creator><creator>Goto, Hiroaki</creator><creator>Hayashi, Akiko</creator><creator>Keino, Dai</creator><creator>Sugiyama, Masanaka</creator><creator>Miyagawa, Naoyuki</creator><creator>Iwasaki, Fuminori</creator><creator>Hamanoue, Satoshi</creator><creator>Yokosuka, Tomoko</creator><creator>Goto, Shoko</creator><creator>Toyoshima, Katsuaki</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5889-2628</orcidid><orcidid>https://orcid.org/0000-0003-0691-0331</orcidid><orcidid>https://orcid.org/0000-0002-0760-9498</orcidid></search><sort><creationdate>202008</creationdate><title>Factors influencing platelet normalization of transient abnormal myelopoiesis</title><author>Nakamura, Wataru ; Goto, Hiroaki ; Hayashi, Akiko ; Keino, Dai ; Sugiyama, Masanaka ; Miyagawa, Naoyuki ; Iwasaki, Fuminori ; Hamanoue, Satoshi ; Yokosuka, Tomoko ; Goto, Shoko ; Toyoshima, Katsuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4434-9114c6104088a509d528a728a726b8278b809b4e223b0a3fa9e5d81e91f87ded3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Blast</topic><topic>Blood Cell Count</topic><topic>Blood platelets</topic><topic>Blood Platelets - metabolism</topic><topic>Diagnosis</topic><topic>Down syndrome</topic><topic>Down Syndrome - blood</topic><topic>Down Syndrome - complications</topic><topic>Down Syndrome - diagnosis</topic><topic>Down's syndrome</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intensive Care Units, Neonatal</topic><topic>Leukemoid Reaction - blood</topic><topic>Leukemoid Reaction - complications</topic><topic>Leukemoid Reaction - diagnosis</topic><topic>Male</topic><topic>Medical records</topic><topic>Myelopoiesis</topic><topic>Neonates</topic><topic>Pediatrics</topic><topic>Platelet Count - methods</topic><topic>Platelets</topic><topic>Retrospective Studies</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - complications</topic><topic>transient abnormal myelopoiesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Wataru</creatorcontrib><creatorcontrib>Goto, Hiroaki</creatorcontrib><creatorcontrib>Hayashi, Akiko</creatorcontrib><creatorcontrib>Keino, Dai</creatorcontrib><creatorcontrib>Sugiyama, Masanaka</creatorcontrib><creatorcontrib>Miyagawa, Naoyuki</creatorcontrib><creatorcontrib>Iwasaki, Fuminori</creatorcontrib><creatorcontrib>Hamanoue, Satoshi</creatorcontrib><creatorcontrib>Yokosuka, Tomoko</creatorcontrib><creatorcontrib>Goto, Shoko</creatorcontrib><creatorcontrib>Toyoshima, Katsuaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Wataru</au><au>Goto, Hiroaki</au><au>Hayashi, Akiko</au><au>Keino, Dai</au><au>Sugiyama, Masanaka</au><au>Miyagawa, Naoyuki</au><au>Iwasaki, Fuminori</au><au>Hamanoue, Satoshi</au><au>Yokosuka, Tomoko</au><au>Goto, Shoko</au><au>Toyoshima, Katsuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors influencing platelet normalization of transient abnormal myelopoiesis</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2020-08</date><risdate>2020</risdate><volume>62</volume><issue>8</issue><spage>907</spage><epage>910</epage><pages>907-910</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
Abnormal blood cell counts are characteristic of patients with Down syndrome and transient abnormal myelopoiesis (TAM). Although some patients with TAM experience prolonged anemia or thrombocytopenia, hematological factors predicting blood cell count recovery have not been reported yet. The aim of this study was to investigate the factors influencing platelet normalization in TAM.
Methods
A retrospective review of the medical records of 21 patients with TAM admitted to the neonatal intensive care unit at Kanagawa Children’s Medical Center between January 2007 and October 2014 was undertaken.
Results
In the 16 of 21 patients (76%) experiencing transient thrombocytopenia, a large number of blasts at diagnosis was found to be significantly associated with late platelet recovery (R = 0.669, P < 0.05), and higher platelet counts at diagnosis were significantly associated with later recovery (R = 0.719, P < 0.01). Indeed, a strong positive correlation between blast and platelet counts at diagnosis was found (R = 0.730, P < 0.01).
Conclusions
Our data suggest that high platelet counts at TAM diagnosis might reflect abnormal thrombocyte production from blasts. Thus, physicians should be aware of the possibility of prolonged thrombocytopenia in patients with TAM who exhibit a high platelet and/or blast count at diagnosis.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>32124502</pmid><doi>10.1111/ped.14214</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-5889-2628</orcidid><orcidid>https://orcid.org/0000-0003-0691-0331</orcidid><orcidid>https://orcid.org/0000-0002-0760-9498</orcidid></addata></record> |
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| identifier | ISSN: 1328-8067 |
| ispartof | Pediatrics international, 2020-08, Vol.62 (8), p.907-910 |
| issn | 1328-8067 1442-200X |
| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Blast Blood Cell Count Blood platelets Blood Platelets - metabolism Diagnosis Down syndrome Down Syndrome - blood Down Syndrome - complications Down Syndrome - diagnosis Down's syndrome Female Humans Infant Infant, Newborn Intensive Care Units, Neonatal Leukemoid Reaction - blood Leukemoid Reaction - complications Leukemoid Reaction - diagnosis Male Medical records Myelopoiesis Neonates Pediatrics Platelet Count - methods Platelets Retrospective Studies Thrombocytopenia Thrombocytopenia - complications transient abnormal myelopoiesis |
| title | Factors influencing platelet normalization of transient abnormal myelopoiesis |
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