Fluconazole‐resistant Candida parapsilosis strains with a Y132F substitution in the ERG11 gene causing invasive infections in a neonatal unit, South Africa

Summary Introduction The prevalence of azole resistance in C parapsilosis is very low in most parts of the world. However, South Africa has reported an exceptionally high prevalence of azole resistance in C parapsilosis strains isolated from candidaemia cases. We aimed to determine the possible mole...

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Veröffentlicht in:	Mycoses 2020-05, Vol.63 (5), p.471-477
Hauptverfasser:	Magobo, Rindidzani E., Lockhart, Shawn R., Govender, Nelesh P., Wadula, Jeannette, Rensburg, van, van Rensburg, Chris Janse, Whitelaw, Andrew, Zietsman, Inge, Miller, Norman, Smith, Peter, van Greune, Johan, Brink, Adrian, Hoosen, Anwar, Perovic, Olga, Nchabaleng, Maphoshane, Orth, Heidi, Coovadia, Yacoob, Badenhorst, Loekie, Moolman, Johan, Peer, AK, Govind, Chetna, Kularatne, Ranmini, Bhagoobhai, Barry, Prinsloo, Ben, Haffejee, Sumayya, Simpson, John, Hoyland, Greta, van Schalkwyk, Marthinus, Bowie, Glenda, Hanise, Patricia, Vasaikar, Sandeep, Wende, Linda, Chiller, Tom, Ahlquist‐Cleveland, Angela, Patel, Jaymati
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid substitution Amino acids Candida parapsilosis Candidemia ERG11 ERG11 gene Fluconazole fluconazole resistance Gene deletion Genotyping Molecular modelling MRR1 Neonates South Africa Strains (organisms)
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