Genipin inhibits the scleral expression of miR-29 and MMP2 and promotes COL1A1 expression in myopic eyes of guinea pigs

Purpose High myopia can lead to blindness. Genipin is a collagen cross-linking agent that may be used to treat myopia. However, the mechanism of action of genipin for the treatment of myopia is unclear. This study investigated the effect of genipin on the scleral expression of the miR-29 cluster, ma...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 2020-05, Vol.258 (5), p.1031-1038
Hauptverfasser:	Wang, Min, Yang, Zhi-Kuan, Liu, Hong, Li, Rui-qin, Liu, Yu, Zhong, Wen-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Science Blindness Blotting, Western Cells, Cultured Cholagogues and Choleretics - pharmacology Collagen (type I) Collagen Type I - genetics Cross-linking Disease Models, Animal Eye lens Female Gelatinase A Gene expression Gene Expression Regulation - physiology Genipin Guinea Pigs HEK293 Cells Humans Iridoids - pharmacology Male Matrix metalloproteinase Matrix Metalloproteinase 2 - genetics Medicine Medicine & Public Health MicroRNAs - genetics Myopia Myopia - genetics Ophthalmology Polymerase chain reaction Real-Time Polymerase Chain Reaction Reverse transcription RNA, Messenger - genetics Sclera - drug effects Sclera - metabolism
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