Hearing loss is associated with cortical thinning in cognitively normal older adults
Background and purpose Hearing loss (HL) is one of the most influential risk factors of dementia in older adults. However, its potential association with neurodegeneration is not well established. The association between HL and cortical thickness in cognitively normal older adults was evaluated. Met...
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| Veröffentlicht in: | European journal of neurology 2020-06, Vol.27 (6), p.1003-1009 |
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| container_title | European journal of neurology |
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| creator | Ha, J. Cho, Y. S. Kim, S. J. Cho, S. H. Kim, J. P. Jung, Y. H. Jang, H. Shin, H.‐Y. Lin, F. R. Na, D. L. Seo, S. W. Moon, I. J. Kim, H. J. |
| description | Background and purpose
Hearing loss (HL) is one of the most influential risk factors of dementia in older adults. However, its potential association with neurodegeneration is not well established. The association between HL and cortical thickness in cognitively normal older adults was evaluated.
Methods
In all, 982 cognitively normal older adults (age ≥65 years) were identified from the Health Promotion Center at the Samsung Medical Center from September 2008 to December 2014. The participants underwent pure‐tone audiometry and brain magnetic resonance imaging. HL was evaluated according to a four‐frequency (0.5, 1, 2, 4 kHz) pure‐tone average. Participants were divided into three groups according to pure‐tone average (normal hearing ≤15 dB, minimal HL 16–25 dB, mild‐to‐severe HL >25 dB). Cortical thickness in the HL groups was compared with that of the normal hearing group.
Results
In women, right ear HL was associated with cortical thinning: the minimal HL group showed cortical thinning in the left frontal and bilateral occipital areas and the mild‐to‐severe HL group showed cortical thinning in the bilateral frontal, right temporal and bilateral occipital areas compared to the normal hearing group. In men, there was no significant association between HL on either side and cortical thickness.
Conclusion
In older women, right ear HL is associated with neurodegeneration even in a cognitively normal state. Therefore, managing HL especially in older women may be an effective strategy for dementia prevention. |
| doi_str_mv | 10.1111/ene.14195 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2370503668</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2403182915</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-9d7d7fbcb39734c7aceb997954acbf9014222437fceba2cc3e055063ea24e7753</originalsourceid><addsrcrecordid>eNp1kMtKAzEUQIMo1tfCH5ABN7oYzbPpLKVUKxTd6DpkMnfalDRTkxlL_97UqS4Es0m4ORwuB6FLgu9IOvfg4Y5wUogDdEL4cJQTxshhejNBckEwGaDTGJcYYyopPkYDRgkVkssT9DYFHayfZ66JMbMx0zE2xuoWqmxj20VmmtBao13WLqz3O9L6NJx729pPcNvMN2GVvhtXQch01bk2nqOjWrsIF_v7DL0_Tt7G03z2-vQ8fpjlhgkm8qKSlaxLU7JCMm6kNlAWhSwE16asC0w4pZQzWae5psYwwELgIQNNOUgp2Bm66b3r0Hx0EFu1stGAc9pD00VFmcQCs-FwlNDrP-iy6YJP2ynKMSMjWpCd8LanTEg5AtRqHexKh60iWO1Sq5RafadO7NXe2JUrqH7Jn7YJuO-BjXWw_d-kJi-TXvkF0leHtQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2403182915</pqid></control><display><type>article</type><title>Hearing loss is associated with cortical thinning in cognitively normal older adults</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ha, J. ; Cho, Y. S. ; Kim, S. J. ; Cho, S. H. ; Kim, J. P. ; Jung, Y. H. ; Jang, H. ; Shin, H.‐Y. ; Lin, F. R. ; Na, D. L. ; Seo, S. W. ; Moon, I. J. ; Kim, H. J.</creator><creatorcontrib>Ha, J. ; Cho, Y. S. ; Kim, S. J. ; Cho, S. H. ; Kim, J. P. ; Jung, Y. H. ; Jang, H. ; Shin, H.‐Y. ; Lin, F. R. ; Na, D. L. ; Seo, S. W. ; Moon, I. J. ; Kim, H. J.</creatorcontrib><description>Background and purpose
Hearing loss (HL) is one of the most influential risk factors of dementia in older adults. However, its potential association with neurodegeneration is not well established. The association between HL and cortical thickness in cognitively normal older adults was evaluated.
Methods
In all, 982 cognitively normal older adults (age ≥65 years) were identified from the Health Promotion Center at the Samsung Medical Center from September 2008 to December 2014. The participants underwent pure‐tone audiometry and brain magnetic resonance imaging. HL was evaluated according to a four‐frequency (0.5, 1, 2, 4 kHz) pure‐tone average. Participants were divided into three groups according to pure‐tone average (normal hearing ≤15 dB, minimal HL 16–25 dB, mild‐to‐severe HL >25 dB). Cortical thickness in the HL groups was compared with that of the normal hearing group.
Results
In women, right ear HL was associated with cortical thinning: the minimal HL group showed cortical thinning in the left frontal and bilateral occipital areas and the mild‐to‐severe HL group showed cortical thinning in the bilateral frontal, right temporal and bilateral occipital areas compared to the normal hearing group. In men, there was no significant association between HL on either side and cortical thickness.
Conclusion
In older women, right ear HL is associated with neurodegeneration even in a cognitively normal state. Therefore, managing HL especially in older women may be an effective strategy for dementia prevention.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.14195</identifier><identifier>PMID: 32125747</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adults ; Audiometry ; cognitively normal ; cortical thickness ; Dementia ; Dementia disorders ; Ear ; Health care facilities ; Health promotion ; Hearing ; Hearing loss ; Magnetic resonance imaging ; Men ; Neurodegeneration ; Neuroimaging ; Older people ; Risk analysis ; Risk factors ; Thickness ; Thinning ; Women</subject><ispartof>European journal of neurology, 2020-06, Vol.27 (6), p.1003-1009</ispartof><rights>2020 European Academy of Neurology</rights><rights>2020 European Academy of Neurology.</rights><rights>Copyright © 2020 European Academy of Neurology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-9d7d7fbcb39734c7aceb997954acbf9014222437fceba2cc3e055063ea24e7753</citedby><cites>FETCH-LOGICAL-c3535-9d7d7fbcb39734c7aceb997954acbf9014222437fceba2cc3e055063ea24e7753</cites><orcidid>0000-0003-3152-1274 ; 0000-0002-3186-9441</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.14195$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.14195$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32125747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ha, J.</creatorcontrib><creatorcontrib>Cho, Y. S.</creatorcontrib><creatorcontrib>Kim, S. J.</creatorcontrib><creatorcontrib>Cho, S. H.</creatorcontrib><creatorcontrib>Kim, J. P.</creatorcontrib><creatorcontrib>Jung, Y. H.</creatorcontrib><creatorcontrib>Jang, H.</creatorcontrib><creatorcontrib>Shin, H.‐Y.</creatorcontrib><creatorcontrib>Lin, F. R.</creatorcontrib><creatorcontrib>Na, D. L.</creatorcontrib><creatorcontrib>Seo, S. W.</creatorcontrib><creatorcontrib>Moon, I. J.</creatorcontrib><creatorcontrib>Kim, H. J.</creatorcontrib><title>Hearing loss is associated with cortical thinning in cognitively normal older adults</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose
Hearing loss (HL) is one of the most influential risk factors of dementia in older adults. However, its potential association with neurodegeneration is not well established. The association between HL and cortical thickness in cognitively normal older adults was evaluated.
Methods
In all, 982 cognitively normal older adults (age ≥65 years) were identified from the Health Promotion Center at the Samsung Medical Center from September 2008 to December 2014. The participants underwent pure‐tone audiometry and brain magnetic resonance imaging. HL was evaluated according to a four‐frequency (0.5, 1, 2, 4 kHz) pure‐tone average. Participants were divided into three groups according to pure‐tone average (normal hearing ≤15 dB, minimal HL 16–25 dB, mild‐to‐severe HL >25 dB). Cortical thickness in the HL groups was compared with that of the normal hearing group.
Results
In women, right ear HL was associated with cortical thinning: the minimal HL group showed cortical thinning in the left frontal and bilateral occipital areas and the mild‐to‐severe HL group showed cortical thinning in the bilateral frontal, right temporal and bilateral occipital areas compared to the normal hearing group. In men, there was no significant association between HL on either side and cortical thickness.
Conclusion
In older women, right ear HL is associated with neurodegeneration even in a cognitively normal state. Therefore, managing HL especially in older women may be an effective strategy for dementia prevention.</description><subject>Adults</subject><subject>Audiometry</subject><subject>cognitively normal</subject><subject>cortical thickness</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Ear</subject><subject>Health care facilities</subject><subject>Health promotion</subject><subject>Hearing</subject><subject>Hearing loss</subject><subject>Magnetic resonance imaging</subject><subject>Men</subject><subject>Neurodegeneration</subject><subject>Neuroimaging</subject><subject>Older people</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Thickness</subject><subject>Thinning</subject><subject>Women</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKAzEUQIMo1tfCH5ABN7oYzbPpLKVUKxTd6DpkMnfalDRTkxlL_97UqS4Es0m4ORwuB6FLgu9IOvfg4Y5wUogDdEL4cJQTxshhejNBckEwGaDTGJcYYyopPkYDRgkVkssT9DYFHayfZ66JMbMx0zE2xuoWqmxj20VmmtBao13WLqz3O9L6NJx729pPcNvMN2GVvhtXQch01bk2nqOjWrsIF_v7DL0_Tt7G03z2-vQ8fpjlhgkm8qKSlaxLU7JCMm6kNlAWhSwE16asC0w4pZQzWae5psYwwELgIQNNOUgp2Bm66b3r0Hx0EFu1stGAc9pD00VFmcQCs-FwlNDrP-iy6YJP2ynKMSMjWpCd8LanTEg5AtRqHexKh60iWO1Sq5RafadO7NXe2JUrqH7Jn7YJuO-BjXWw_d-kJi-TXvkF0leHtQ</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Ha, J.</creator><creator>Cho, Y. S.</creator><creator>Kim, S. J.</creator><creator>Cho, S. H.</creator><creator>Kim, J. P.</creator><creator>Jung, Y. H.</creator><creator>Jang, H.</creator><creator>Shin, H.‐Y.</creator><creator>Lin, F. R.</creator><creator>Na, D. L.</creator><creator>Seo, S. W.</creator><creator>Moon, I. J.</creator><creator>Kim, H. J.</creator><general>John Wiley & Sons, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3152-1274</orcidid><orcidid>https://orcid.org/0000-0002-3186-9441</orcidid></search><sort><creationdate>202006</creationdate><title>Hearing loss is associated with cortical thinning in cognitively normal older adults</title><author>Ha, J. ; Cho, Y. S. ; Kim, S. J. ; Cho, S. H. ; Kim, J. P. ; Jung, Y. H. ; Jang, H. ; Shin, H.‐Y. ; Lin, F. R. ; Na, D. L. ; Seo, S. W. ; Moon, I. J. ; Kim, H. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-9d7d7fbcb39734c7aceb997954acbf9014222437fceba2cc3e055063ea24e7753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adults</topic><topic>Audiometry</topic><topic>cognitively normal</topic><topic>cortical thickness</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Ear</topic><topic>Health care facilities</topic><topic>Health promotion</topic><topic>Hearing</topic><topic>Hearing loss</topic><topic>Magnetic resonance imaging</topic><topic>Men</topic><topic>Neurodegeneration</topic><topic>Neuroimaging</topic><topic>Older people</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Thickness</topic><topic>Thinning</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ha, J.</creatorcontrib><creatorcontrib>Cho, Y. S.</creatorcontrib><creatorcontrib>Kim, S. J.</creatorcontrib><creatorcontrib>Cho, S. H.</creatorcontrib><creatorcontrib>Kim, J. P.</creatorcontrib><creatorcontrib>Jung, Y. H.</creatorcontrib><creatorcontrib>Jang, H.</creatorcontrib><creatorcontrib>Shin, H.‐Y.</creatorcontrib><creatorcontrib>Lin, F. R.</creatorcontrib><creatorcontrib>Na, D. L.</creatorcontrib><creatorcontrib>Seo, S. W.</creatorcontrib><creatorcontrib>Moon, I. J.</creatorcontrib><creatorcontrib>Kim, H. J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ha, J.</au><au>Cho, Y. S.</au><au>Kim, S. J.</au><au>Cho, S. H.</au><au>Kim, J. P.</au><au>Jung, Y. H.</au><au>Jang, H.</au><au>Shin, H.‐Y.</au><au>Lin, F. R.</au><au>Na, D. L.</au><au>Seo, S. W.</au><au>Moon, I. J.</au><au>Kim, H. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hearing loss is associated with cortical thinning in cognitively normal older adults</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2020-06</date><risdate>2020</risdate><volume>27</volume><issue>6</issue><spage>1003</spage><epage>1009</epage><pages>1003-1009</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><abstract>Background and purpose
Hearing loss (HL) is one of the most influential risk factors of dementia in older adults. However, its potential association with neurodegeneration is not well established. The association between HL and cortical thickness in cognitively normal older adults was evaluated.
Methods
In all, 982 cognitively normal older adults (age ≥65 years) were identified from the Health Promotion Center at the Samsung Medical Center from September 2008 to December 2014. The participants underwent pure‐tone audiometry and brain magnetic resonance imaging. HL was evaluated according to a four‐frequency (0.5, 1, 2, 4 kHz) pure‐tone average. Participants were divided into three groups according to pure‐tone average (normal hearing ≤15 dB, minimal HL 16–25 dB, mild‐to‐severe HL >25 dB). Cortical thickness in the HL groups was compared with that of the normal hearing group.
Results
In women, right ear HL was associated with cortical thinning: the minimal HL group showed cortical thinning in the left frontal and bilateral occipital areas and the mild‐to‐severe HL group showed cortical thinning in the bilateral frontal, right temporal and bilateral occipital areas compared to the normal hearing group. In men, there was no significant association between HL on either side and cortical thickness.
Conclusion
In older women, right ear HL is associated with neurodegeneration even in a cognitively normal state. Therefore, managing HL especially in older women may be an effective strategy for dementia prevention.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>32125747</pmid><doi>10.1111/ene.14195</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3152-1274</orcidid><orcidid>https://orcid.org/0000-0002-3186-9441</orcidid></addata></record> |
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| ispartof | European journal of neurology, 2020-06, Vol.27 (6), p.1003-1009 |
| issn | 1351-5101 1468-1331 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Adults Audiometry cognitively normal cortical thickness Dementia Dementia disorders Ear Health care facilities Health promotion Hearing Hearing loss Magnetic resonance imaging Men Neurodegeneration Neuroimaging Older people Risk analysis Risk factors Thickness Thinning Women |
| title | Hearing loss is associated with cortical thinning in cognitively normal older adults |
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