Impact of background factors on outcomes of pharmacological therapy for chronic low back pain: A nationwide multicenter prospective study

Chronic low back pain (CLBP) is a major cause of chronic pain with nociceptive, neuropathic or both pain components, and a leading cause of disability. The objectives of this study were to determine the impact of background factors including previous use of drugs on outcomes of pharmacological thera...

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Veröffentlicht in:Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2021-01, Vol.26 (1), p.92-102
Hauptverfasser: Imagama, Shiro, Murakami, Hideki, Kaito, Takashi, Matsuyama, Yukihiro, Yamashita, Toshihiko, Kawakami, Mamoru, Takahashi, Kazuhisa, Yoshida, Munehito, Ohtori, Seiji, Taguchi, Toshihiko, Haro, Hirotaka, Taneichi, Hiroshi, Yamazaki, Masashi, Inoue, Gen, Nishida, Kotaro, Yamada, Hiroshi, Kabata, Daijiro, Shintani, Ayumi, Iwasaki, Motoki, Ito, Manabu, Miyakoshi, Naohisa, Yonenobu, Kazuo, Takura, Tomoyuki, Mochida, Joji
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container_title Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
container_volume 26
creator Imagama, Shiro
Murakami, Hideki
Kaito, Takashi
Matsuyama, Yukihiro
Yamashita, Toshihiko
Kawakami, Mamoru
Takahashi, Kazuhisa
Yoshida, Munehito
Ohtori, Seiji
Taguchi, Toshihiko
Haro, Hirotaka
Taneichi, Hiroshi
Yamazaki, Masashi
Inoue, Gen
Nishida, Kotaro
Yamada, Hiroshi
Kabata, Daijiro
Shintani, Ayumi
Iwasaki, Motoki
Ito, Manabu
Miyakoshi, Naohisa
Yonenobu, Kazuo
Takura, Tomoyuki
Mochida, Joji
description Chronic low back pain (CLBP) is a major cause of chronic pain with nociceptive, neuropathic or both pain components, and a leading cause of disability. The objectives of this study were to determine the impact of background factors including previous use of drugs on outcomes of pharmacological therapy for CLBP in a nationwide multicenter prospective study. The subjects were 474 patients (male: 41.9%, median age: 73.0) with CLBP. Background factors that could influence outcomes after pharmacological treatment for 6 months were examined: age, gender, body mass index (BMI), duration of CLBP, osteoporosis, history of spinal surgery, history of malignant tumor, smoking habit, employment status (yes or no), exercise habit (frequency), number of live-in family members, having something to do for pleasure, Center for Epidemiologic Studies depression scale (CES-D) score, and medication at baseline. Japanese Orthopaedic Association (JOA) score, visual analogue scale (VAS) for LBP, JOA Back Pain Evaluation Questionnaire (JOABPEQ), Roland-Morris Disability Questionnaire (RDQ), Short-form 8-item health survey (SF-8), and EQ-5D were used for evaluation at baseline and after 6 months. Multivariate linear regression models were used in statistical analysis. Drugs for neuropathic pain at baseline (p 
doi_str_mv 10.1016/j.jos.2020.02.003
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The objectives of this study were to determine the impact of background factors including previous use of drugs on outcomes of pharmacological therapy for CLBP in a nationwide multicenter prospective study. The subjects were 474 patients (male: 41.9%, median age: 73.0) with CLBP. Background factors that could influence outcomes after pharmacological treatment for 6 months were examined: age, gender, body mass index (BMI), duration of CLBP, osteoporosis, history of spinal surgery, history of malignant tumor, smoking habit, employment status (yes or no), exercise habit (frequency), number of live-in family members, having something to do for pleasure, Center for Epidemiologic Studies depression scale (CES-D) score, and medication at baseline. 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