Scaffolds and coatings for bone regeneration
Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects (
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2020-03, Vol.31 (3), p.27-27, Article 27 |
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| container_title | Journal of materials science. Materials in medicine |
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| creator | Pereira, Helena Filipa Cengiz, Ibrahim Fatih Silva, Filipe Samuel Reis, Rui Luís Oliveira, Joaquim Miguel |
| description | Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects ( |
| doi_str_mv | 10.1007/s10856-020-06364-y |
| format | Article |
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Autografts are, still, being used as preferred to treat large bone defects. Mostly, due to the presence of living differentiated and progenitor cells, its osteogenic, osteoinductive and osteoconductive properties that allow osteogenesis, vascularization, and provide structural support. Bone tissue engineering strategies have been proposed to overcome the limited supply of grafts. Complete and successful bone regeneration can be influenced by several factors namely: the age of the patient, health, gender and is expected that the ideal scaffold for bone regeneration combines factors such as bioactivity and osteoinductivity. The commercially available products have as their main function the replacement of bone. Moreover, scaffolds still present limitations including poor osteointegration and limited vascularization. The introduction of pores in scaffolds are being used to promote the osteointegration as it allows cell and vessel infiltration. Moreover, combinations with growth factors or coatings have been explored as they can improve the osteoconductive and osteoinductive properties of the scaffold. This review focuses on the bone defects treatments and on the research of scaffolds for bone regeneration. Moreover, it summarizes the latest progress in the development of coatings used in bone tissue engineering. Despite the interesting advances which include the development of hybrid scaffolds, there are still important challenges that need to be addressed in order to fasten translation of scaffolds into the clinical scenario. Finally, we must reflect on the main challenges for bone tissue regeneration. There is a need to achieve a proper mechanical properties to bear the load of movements; have a scaffolds with a structure that fit the bone anatomy.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-020-06364-y</identifier><identifier>PMID: 32124052</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alginates - chemistry ; Animals ; Autografts ; Biocompatible Materials - chemistry ; Biological activity ; Biomaterials ; Biomechanical Phenomena ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Blood vessels ; Bone Development ; Bone grafts ; Bone growth ; Bone healing ; Bone Regeneration ; Bones ; Cell Differentiation ; Cell Proliferation ; Cells (biology) ; Ceramics ; Chemistry and Materials Science ; Chondrocytes - cytology ; Coatings ; Composites ; Defects ; Elasticity ; Female ; Fractures ; Glass ; Growth factors ; Humans ; Materials Science ; Mechanical properties ; Mesenchymal Stem Cells - cytology ; Mice ; Middle Aged ; Natural Materials ; Nonunion ; Osseointegration ; Osteoblasts - cytology ; Osteoconduction ; Osteogenesis ; Osteoprogenitor cells ; Polymer Sciences ; Polymers - chemistry ; Porosity ; Pressure ; Progenitor cells ; Rabbits ; Regeneration ; Regeneration (physiology) ; Regenerative Medicine/Tissue Engineering ; Scaffolds ; Sheep ; Solvents ; Surfaces and Interfaces ; Thin Films ; Tissue engineering ; Tissue Engineering - instrumentation ; Tissue Engineering - methods ; Tissue Engineering Constructs and Cell Substrates ; Tissue Scaffolds ; Vascularization</subject><ispartof>Journal of materials science. Materials in medicine, 2020-03, Vol.31 (3), p.27-27, Article 27</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Journal of Materials Science: Materials in Medicine is a copyright of Springer, (2020). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-9aba566a84c64f96014d434e958741c4195820306965a7192c16232490a5c84b3</citedby><cites>FETCH-LOGICAL-c481t-9aba566a84c64f96014d434e958741c4195820306965a7192c16232490a5c84b3</cites><orcidid>0000-0003-2053-0968</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-020-06364-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-020-06364-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32124052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pereira, Helena Filipa</creatorcontrib><creatorcontrib>Cengiz, Ibrahim Fatih</creatorcontrib><creatorcontrib>Silva, Filipe Samuel</creatorcontrib><creatorcontrib>Reis, Rui Luís</creatorcontrib><creatorcontrib>Oliveira, Joaquim Miguel</creatorcontrib><title>Scaffolds and coatings for bone regeneration</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects (<6 mm) and clinical intervention is needed for critical-size defects and beyond that along with non-union bone fractures and bone defects larger than critical size represent a major healthcare problem. Autografts are, still, being used as preferred to treat large bone defects. Mostly, due to the presence of living differentiated and progenitor cells, its osteogenic, osteoinductive and osteoconductive properties that allow osteogenesis, vascularization, and provide structural support. Bone tissue engineering strategies have been proposed to overcome the limited supply of grafts. Complete and successful bone regeneration can be influenced by several factors namely: the age of the patient, health, gender and is expected that the ideal scaffold for bone regeneration combines factors such as bioactivity and osteoinductivity. The commercially available products have as their main function the replacement of bone. Moreover, scaffolds still present limitations including poor osteointegration and limited vascularization. The introduction of pores in scaffolds are being used to promote the osteointegration as it allows cell and vessel infiltration. Moreover, combinations with growth factors or coatings have been explored as they can improve the osteoconductive and osteoinductive properties of the scaffold. This review focuses on the bone defects treatments and on the research of scaffolds for bone regeneration. Moreover, it summarizes the latest progress in the development of coatings used in bone tissue engineering. Despite the interesting advances which include the development of hybrid scaffolds, there are still important challenges that need to be addressed in order to fasten translation of scaffolds into the clinical scenario. Finally, we must reflect on the main challenges for bone tissue regeneration. There is a need to achieve a proper mechanical properties to bear the load of movements; have a scaffolds with a structure that fit the bone anatomy.</description><subject>Alginates - chemistry</subject><subject>Animals</subject><subject>Autografts</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological activity</subject><subject>Biomaterials</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Blood vessels</subject><subject>Bone Development</subject><subject>Bone grafts</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Bone Regeneration</subject><subject>Bones</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Cells (biology)</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Chondrocytes - cytology</subject><subject>Coatings</subject><subject>Composites</subject><subject>Defects</subject><subject>Elasticity</subject><subject>Female</subject><subject>Fractures</subject><subject>Glass</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Materials Science</subject><subject>Mechanical properties</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Natural Materials</subject><subject>Nonunion</subject><subject>Osseointegration</subject><subject>Osteoblasts - cytology</subject><subject>Osteoconduction</subject><subject>Osteogenesis</subject><subject>Osteoprogenitor cells</subject><subject>Polymer Sciences</subject><subject>Polymers - chemistry</subject><subject>Porosity</subject><subject>Pressure</subject><subject>Progenitor cells</subject><subject>Rabbits</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Scaffolds</subject><subject>Sheep</subject><subject>Solvents</subject><subject>Surfaces and Interfaces</subject><subject>Thin Films</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - instrumentation</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Engineering Constructs and Cell Substrates</subject><subject>Tissue 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Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2020-03-02</date><risdate>2020</risdate><volume>31</volume><issue>3</issue><spage>27</spage><epage>27</epage><pages>27-27</pages><artnum>27</artnum><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects (<6 mm) and clinical intervention is needed for critical-size defects and beyond that along with non-union bone fractures and bone defects larger than critical size represent a major healthcare problem. Autografts are, still, being used as preferred to treat large bone defects. Mostly, due to the presence of living differentiated and progenitor cells, its osteogenic, osteoinductive and osteoconductive properties that allow osteogenesis, vascularization, and provide structural support. Bone tissue engineering strategies have been proposed to overcome the limited supply of grafts. Complete and successful bone regeneration can be influenced by several factors namely: the age of the patient, health, gender and is expected that the ideal scaffold for bone regeneration combines factors such as bioactivity and osteoinductivity. The commercially available products have as their main function the replacement of bone. Moreover, scaffolds still present limitations including poor osteointegration and limited vascularization. The introduction of pores in scaffolds are being used to promote the osteointegration as it allows cell and vessel infiltration. Moreover, combinations with growth factors or coatings have been explored as they can improve the osteoconductive and osteoinductive properties of the scaffold. This review focuses on the bone defects treatments and on the research of scaffolds for bone regeneration. Moreover, it summarizes the latest progress in the development of coatings used in bone tissue engineering. Despite the interesting advances which include the development of hybrid scaffolds, there are still important challenges that need to be addressed in order to fasten translation of scaffolds into the clinical scenario. Finally, we must reflect on the main challenges for bone tissue regeneration. There is a need to achieve a proper mechanical properties to bear the load of movements; have a scaffolds with a structure that fit the bone anatomy.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32124052</pmid><doi>10.1007/s10856-020-06364-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2053-0968</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alginates - chemistry Animals Autografts Biocompatible Materials - chemistry Biological activity Biomaterials Biomechanical Phenomena Biomedical Engineering and Bioengineering Biomedical materials Blood vessels Bone Development Bone grafts Bone growth Bone healing Bone Regeneration Bones Cell Differentiation Cell Proliferation Cells (biology) Ceramics Chemistry and Materials Science Chondrocytes - cytology Coatings Composites Defects Elasticity Female Fractures Glass Growth factors Humans Materials Science Mechanical properties Mesenchymal Stem Cells - cytology Mice Middle Aged Natural Materials Nonunion Osseointegration Osteoblasts - cytology Osteoconduction Osteogenesis Osteoprogenitor cells Polymer Sciences Polymers - chemistry Porosity Pressure Progenitor cells Rabbits Regeneration Regeneration (physiology) Regenerative Medicine/Tissue Engineering Scaffolds Sheep Solvents Surfaces and Interfaces Thin Films Tissue engineering Tissue Engineering - instrumentation Tissue Engineering - methods Tissue Engineering Constructs and Cell Substrates Tissue Scaffolds Vascularization |
| title | Scaffolds and coatings for bone regeneration |
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