Dysfunction of inflammation-resolving pathways is associated with postoperative cognitive decline in elderly mice

•POCD was significantly higher in elderly mice than in adult mice 24 h post operation.•Cognitive decline among elderly mice was associated with dysfunction of CAP.•Cholinergic agonists can reverse the neuro-inflammatory response caused by trauma. Postoperative cognitive dysfunction (POCD) refers to...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Behavioural brain research 2020-05, Vol.386, p.112538-112538, Article 112538
Hauptverfasser:	Gong, Moxuan, Wang, Gongming, Li, Guodong, Liu, Jie, Sun, Panpan, Xu, Lichi, Li, Jingjing, Guo, Yanjing, Zhang, Mengyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholinergic anti-inflammatory pathway Cognitive decline Neuro-inflammation Postoperative cognitive dysfunction α7nAch receptor agonists
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!