Inhibition of profibrotic signalling enhances the 5-azacytidine-induced reprogramming of fibroblasts into cardiomyocytes

•Improving the conversion efficiency of CFs to cardiac myocytes is a challenging task.•The appearance of fibrotic prevents cardiac reprogramming.•Inhibition of pro-fibrotic signalling by the TGF-β receptor inhibitor enhances the reprogramming of CFs to iCMs. Recent studies have shown that cardiac fi...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2020-05, Vol.122, p.105733-105733, Article 105733
Hauptverfasser:	Jia, Yangyang, Chang, Yuqiao, Sun, Panwen, Li, He, Guo, Zhikun
Format:	Artikel
Sprache:	eng
Schlagworte:	5-azacytidine Cardiac fibroblasts Differentiation Induced cardiomyocytes TGF-β inhibitor
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