Glucose regulates hypoxia‐induced NLRP3 inflammasome activation in macrophages

Although the intimate linkage between hypoxia and inflammation is well known, the mechanism underlying this linkage has not been fully understood. Nucleotide‐binding oligomerization domain‐like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is an intracellular multiprotein comp...

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Veröffentlicht in:	Journal of cellular physiology 2020-10, Vol.235 (10), p.7554-7566
Hauptverfasser:	Watanabe, Sachiko, Usui‐Kawanishi, Fumitake, Karasawa, Tadayoshi, Kimura, Hiroaki, Kamata, Ryo, Komada, Takanori, Inoue, Yoshiyuki, Mise, Nathan, Kasahara, Tadashi, Takahashi, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine triphosphate Adenosine Triphosphate - metabolism Animals Apoptosis Apoptosis - drug effects Atomic absorption analysis Atomic absorption spectroscopy Caspase Caspase 1 - metabolism Cell activation Cell death Cell Death - drug effects Cells, Cultured Deprivation Efflux Glucose Glucose - metabolism Glycolysis Hypoxia Hypoxia - metabolism Inflammasomes Inflammasomes - metabolism Inflammation Inflammation - metabolism Inflammatory diseases Interleukin-1beta - metabolism Interleukins interleukin‐1 Intracellular L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lipopolysaccharides Lipopolysaccharides - pharmacology Macrophages Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Nucleotides Oligomerization Pathogenesis Potassium Potassium - metabolism potassium efflux Pyrin protein Pyroptosis Regulatory mechanisms (biology) Signal Transduction - drug effects Signal Transduction - physiology Spectral analysis Spectrometry
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