Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells

Panaxadiol is a triterpenoid sapogenin monomeric compound found in the roots of Panax ginseng and has a variety of biological activities such as neuroprotective and anti-tumour functions. However, the mechanisms how panaxadiol exerts the anticancer effects remain unknown. The current study aimed to...

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Veröffentlicht in:	Pharmacological research 2020-05, Vol.155, p.104727-104727, Article 104727
Hauptverfasser:	Wang, Zhe, Li, Ming Yue, Zhang, Zhi Hong, Zuo, Hong Xiang, Wang, Jing Ying, Xing, Yue, Ri, MyongHak, Jin, Hong Lan, Jin, Cheng Hua, Xu, Guang Hua, Piao, Lian Xun, Jiang, Chang Gao, Ma, Juan, Jin, Xuejun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Cancer immunotherapy Cell Line Cell Proliferation - drug effects Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - metabolism Ginsenosides - pharmacology Ginsenosides - therapeutic use Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice, Inbred BALB C Mice, Nude Nature product Panax ginseng PD-L1 inhibitor STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism T cells T-Lymphocytes - drug effects T-Lymphocytes - immunology
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