The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene

Plasmacytoid dendritic cells (pDCs) are characterized by an exclusive expression of nucleic acid sensing Toll-like receptor 7 (TLR7) and TLR9, and production of high amounts of type I interferon (IFN) in response to TLR7/9 signaling. This function is crucial for both antiviral immunity and the patho...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical and biophysical research communications 2020-04, Vol.525 (2), p.477-482
Hauptverfasser:	Miyazaki, Ryo, Saiga, Hiroyuki, Kato, Takumi, Bakoshi, Takamitsu, Senba, Rina, Shintani, An, Suzuki, Makiko, Takao, Kenjiro, Sasaki, Izumi, Iizuka, Akihiko, Sugiyama, Masanaka, Iwami, Nana, Fukuda-Ohta, Yuri, Hemmi, Hiroaki, Tanaka, Takashi, Miyake, Minoru, Kaisho, Tsuneyasu, Hoshino, Katsuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Interferon-α IRF-7 p300 Plasmacytoid dendritic cell Spi-B
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!