Enantiodivergent Formation of C–P Bonds: Synthesis of P‑Chiral Phosphines and Methylphosphonate Oligonucleotides

Phosphorus Incorporation (PI, abbreviated Π) reagents for the modular, scalable, and stereo­specific synthesis of chiral phosphines and methyl­phosphonate nucleotides are reported. Synthesized from trans-limonene oxide, this reagent class displays an unexpected reactivity profile and enables access...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-03, Vol.142 (12), p.5785-5792
Hauptverfasser:	Xu, Dongmin, Rivas-Bascón, Nazaret, Padial, Natalia M, Knouse, Kyle W, Zheng, Bin, Vantourout, Julien C, Schmidt, Michael A, Eastgate, Martin D, Baran, Phil S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclohexane Monoterpenes - chemistry Indicators and Reagents - chemistry Oligonucleotides - chemical synthesis Organophosphonates - chemical synthesis Oxidation-Reduction Phosphines - chemical synthesis Stereoisomerism
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