A New Clinical and Immunovirological Score for Predicting the Risk of Late Severe Infection in Solid Organ Transplant Recipients: The CLIV Score
Abstract Background We aimed at constructing a composite score based on Epstein-Barr virus DNAemia (EBVd) and simple clinical and immunological parameters to predict late severe infection (LI) beyond month 6 in solid organ transplantation (SOT) recipients. Methods Kidney and liver transplant recipie...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2020-07, Vol.222 (3), p.479-487 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 487 |
|---|---|
| container_issue | 3 |
| container_start_page | 479 |
| container_title | The Journal of infectious diseases |
| container_volume | 222 |
| creator | San-Juan, Rafael Fernández-Ruiz, Mario Ruiz-Ruigómez, María López-Medrano, Francisco Ruiz-Merlo, Tamara Andrés, Amado Loinaz, Carmelo Len, Oscar Azancot, María Antonieta Montejo, Miguel Rodriguez-Alvarez, Regino Fortún, Jesús Escudero-Sánchez, Rosa Giménez, Estela Lora, David Albert, Eliseo Navarro, David Aguado, José María |
| description | Abstract
Background
We aimed at constructing a composite score based on Epstein-Barr virus DNAemia (EBVd) and simple clinical and immunological parameters to predict late severe infection (LI) beyond month 6 in solid organ transplantation (SOT) recipients.
Methods
Kidney and liver transplant recipients between May 2014 and August 2016 at 4 participating centers were included. Serum immunoglobulins and complement factors, peripheral blood lymphocyte subpopulations, and whole blood EBVd were determined at months 1, 3, and 6. Cox regression analyses were performed to generate a weighted score for the prediction of LI.
Results
Overall, 309 SOT recipients were followed-up for a median of 1000 days from transplant (interquartile range, 822–1124). Late severe infection occurred in 104 patients (33.6%). The CLIV Score consisted of the following variables at month 6: high-level EBVd (>1500 IU/mL) and recurrent infection during the previous months (6 points); recipient age ≥70 years and chronic graft dysfunction (5 points); cytomegalovirus mismatch (4 points); and CD8+ T-cell count |
| doi_str_mv | 10.1093/infdis/jiaa090 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2369439151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/infdis/jiaa090</oup_id><sourcerecordid>2473810145</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-adc076e6d7be26fb2af7fcfdb9b4af345ea622bbb66a435d1162eae14875b2b33</originalsourceid><addsrcrecordid>eNqF0ctu1DAUBmALUdFpYcsSWWJDF2l9SZwJu2rEZaRRizoD28iX48FDYgc7KeIteGTcZmDBhtWRrM__OdKP0EtKLilp-JXz1rh0dXBSkoY8QQta8boQgvKnaEEIYwVdNs0pOkvpQAgpuaifoVPOKGVkWS3Qr2t8Az_wqnPeadlh6Q1e9_3kw72LoQv7x9etDhGwDRF_imCcHp3f4_Er4DuXvuFg8UaOgLdwD5mtvYUsgsfO423onMG3cS893kXp09BJP-I70G5w4Mf0Fu9yzmqz_jJveY5OrOwSvDjOc_T5_bvd6mOxuf2wXl1vCs2beiyk0aQWIEytgAmrmLS11daoRpXS8rICKRhTSgkhS14ZSgUDCbRc1pViivNz9GbOHWL4PkEa294lDV0-D8KUWsZFU_KGVjTT1__QQ5iiz9e1rKz5khJaVlldzkrHkFIE2w7R9TL-bClpH7pq567aY1f5w6tj7KR6MH_5n3IyuJhBmIb_hf0GczahAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473810145</pqid></control><display><type>article</type><title>A New Clinical and Immunovirological Score for Predicting the Risk of Late Severe Infection in Solid Organ Transplant Recipients: The CLIV Score</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>San-Juan, Rafael ; Fernández-Ruiz, Mario ; Ruiz-Ruigómez, María ; López-Medrano, Francisco ; Ruiz-Merlo, Tamara ; Andrés, Amado ; Loinaz, Carmelo ; Len, Oscar ; Azancot, María Antonieta ; Montejo, Miguel ; Rodriguez-Alvarez, Regino ; Fortún, Jesús ; Escudero-Sánchez, Rosa ; Giménez, Estela ; Lora, David ; Albert, Eliseo ; Navarro, David ; Aguado, José María</creator><creatorcontrib>San-Juan, Rafael ; Fernández-Ruiz, Mario ; Ruiz-Ruigómez, María ; López-Medrano, Francisco ; Ruiz-Merlo, Tamara ; Andrés, Amado ; Loinaz, Carmelo ; Len, Oscar ; Azancot, María Antonieta ; Montejo, Miguel ; Rodriguez-Alvarez, Regino ; Fortún, Jesús ; Escudero-Sánchez, Rosa ; Giménez, Estela ; Lora, David ; Albert, Eliseo ; Navarro, David ; Aguado, José María ; Spanish Network for Research in Infectious Diseases (Red Española de Investigación en Patología Infecciosa [REIPI] RD16/0016)</creatorcontrib><description>Abstract
Background
We aimed at constructing a composite score based on Epstein-Barr virus DNAemia (EBVd) and simple clinical and immunological parameters to predict late severe infection (LI) beyond month 6 in solid organ transplantation (SOT) recipients.
Methods
Kidney and liver transplant recipients between May 2014 and August 2016 at 4 participating centers were included. Serum immunoglobulins and complement factors, peripheral blood lymphocyte subpopulations, and whole blood EBVd were determined at months 1, 3, and 6. Cox regression analyses were performed to generate a weighted score for the prediction of LI.
Results
Overall, 309 SOT recipients were followed-up for a median of 1000 days from transplant (interquartile range, 822–1124). Late severe infection occurred in 104 patients (33.6%). The CLIV Score consisted of the following variables at month 6: high-level EBVd (>1500 IU/mL) and recurrent infection during the previous months (6 points); recipient age ≥70 years and chronic graft dysfunction (5 points); cytomegalovirus mismatch (4 points); and CD8+ T-cell count <400 cells/μL (2 points). The area under receiver operating characteristics curve was 0.77 (95% confidence interval, 0.71–0.84). The risk of LI at day 1000 was as follows: score 0, 12.6%; score 2–5, 25.5%; score 6–9, 52.7%; score ≥10, 73.5%.
Conclusions
While waiting for further external validation, the CLIV Score based on clinical and immune-virological parameters is potentially useful to stratify the risk of LI after SOT.
The CLIV Score consisted of the following variables at month 6: high-level EBVd and recurrent infection during the previous months; recipient age ≥70 years and chronic graft dysfunction; CMV mismatch; and CD8+ T-cell count <400 cells/μL.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiaa090</identifier><identifier>PMID: 32112085</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Aged ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Cytomegalovirus ; DNA, Viral - blood ; Epstein-Barr virus ; Epstein-Barr Virus Infections - diagnosis ; Epstein-Barr Virus Infections - virology ; Female ; Herpesvirus 4, Human - isolation & purification ; Humans ; Immunoglobulins ; Immunosuppression ; Infections ; Kidney transplantation ; Leukocyte Count ; Liver transplantation ; Lymphocytes T ; Male ; Middle Aged ; Multivariate Analysis ; Opportunistic Infections - etiology ; Organ Transplantation - adverse effects ; Peripheral blood ; Postoperative Complications - etiology ; Recurrent infection ; ROC Curve ; Transplants & implants</subject><ispartof>The Journal of infectious diseases, 2020-07, Vol.222 (3), p.479-487</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-adc076e6d7be26fb2af7fcfdb9b4af345ea622bbb66a435d1162eae14875b2b33</citedby><cites>FETCH-LOGICAL-c397t-adc076e6d7be26fb2af7fcfdb9b4af345ea622bbb66a435d1162eae14875b2b33</cites><orcidid>0000-0003-3446-1991</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32112085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>San-Juan, Rafael</creatorcontrib><creatorcontrib>Fernández-Ruiz, Mario</creatorcontrib><creatorcontrib>Ruiz-Ruigómez, María</creatorcontrib><creatorcontrib>López-Medrano, Francisco</creatorcontrib><creatorcontrib>Ruiz-Merlo, Tamara</creatorcontrib><creatorcontrib>Andrés, Amado</creatorcontrib><creatorcontrib>Loinaz, Carmelo</creatorcontrib><creatorcontrib>Len, Oscar</creatorcontrib><creatorcontrib>Azancot, María Antonieta</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Rodriguez-Alvarez, Regino</creatorcontrib><creatorcontrib>Fortún, Jesús</creatorcontrib><creatorcontrib>Escudero-Sánchez, Rosa</creatorcontrib><creatorcontrib>Giménez, Estela</creatorcontrib><creatorcontrib>Lora, David</creatorcontrib><creatorcontrib>Albert, Eliseo</creatorcontrib><creatorcontrib>Navarro, David</creatorcontrib><creatorcontrib>Aguado, José María</creatorcontrib><creatorcontrib>Spanish Network for Research in Infectious Diseases (Red Española de Investigación en Patología Infecciosa [REIPI] RD16/0016)</creatorcontrib><title>A New Clinical and Immunovirological Score for Predicting the Risk of Late Severe Infection in Solid Organ Transplant Recipients: The CLIV Score</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Background
We aimed at constructing a composite score based on Epstein-Barr virus DNAemia (EBVd) and simple clinical and immunological parameters to predict late severe infection (LI) beyond month 6 in solid organ transplantation (SOT) recipients.
Methods
Kidney and liver transplant recipients between May 2014 and August 2016 at 4 participating centers were included. Serum immunoglobulins and complement factors, peripheral blood lymphocyte subpopulations, and whole blood EBVd were determined at months 1, 3, and 6. Cox regression analyses were performed to generate a weighted score for the prediction of LI.
Results
Overall, 309 SOT recipients were followed-up for a median of 1000 days from transplant (interquartile range, 822–1124). Late severe infection occurred in 104 patients (33.6%). The CLIV Score consisted of the following variables at month 6: high-level EBVd (>1500 IU/mL) and recurrent infection during the previous months (6 points); recipient age ≥70 years and chronic graft dysfunction (5 points); cytomegalovirus mismatch (4 points); and CD8+ T-cell count <400 cells/μL (2 points). The area under receiver operating characteristics curve was 0.77 (95% confidence interval, 0.71–0.84). The risk of LI at day 1000 was as follows: score 0, 12.6%; score 2–5, 25.5%; score 6–9, 52.7%; score ≥10, 73.5%.
Conclusions
While waiting for further external validation, the CLIV Score based on clinical and immune-virological parameters is potentially useful to stratify the risk of LI after SOT.
The CLIV Score consisted of the following variables at month 6: high-level EBVd and recurrent infection during the previous months; recipient age ≥70 years and chronic graft dysfunction; CMV mismatch; and CD8+ T-cell count <400 cells/μL.</description><subject>Adult</subject><subject>Aged</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cytomegalovirus</subject><subject>DNA, Viral - blood</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - diagnosis</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Female</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunosuppression</subject><subject>Infections</subject><subject>Kidney transplantation</subject><subject>Leukocyte Count</subject><subject>Liver transplantation</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Opportunistic Infections - etiology</subject><subject>Organ Transplantation - adverse effects</subject><subject>Peripheral blood</subject><subject>Postoperative Complications - etiology</subject><subject>Recurrent infection</subject><subject>ROC Curve</subject><subject>Transplants & implants</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctu1DAUBmALUdFpYcsSWWJDF2l9SZwJu2rEZaRRizoD28iX48FDYgc7KeIteGTcZmDBhtWRrM__OdKP0EtKLilp-JXz1rh0dXBSkoY8QQta8boQgvKnaEEIYwVdNs0pOkvpQAgpuaifoVPOKGVkWS3Qr2t8Az_wqnPeadlh6Q1e9_3kw72LoQv7x9etDhGwDRF_imCcHp3f4_Er4DuXvuFg8UaOgLdwD5mtvYUsgsfO423onMG3cS893kXp09BJP-I70G5w4Mf0Fu9yzmqz_jJveY5OrOwSvDjOc_T5_bvd6mOxuf2wXl1vCs2beiyk0aQWIEytgAmrmLS11daoRpXS8rICKRhTSgkhS14ZSgUDCbRc1pViivNz9GbOHWL4PkEa294lDV0-D8KUWsZFU_KGVjTT1__QQ5iiz9e1rKz5khJaVlldzkrHkFIE2w7R9TL-bClpH7pq567aY1f5w6tj7KR6MH_5n3IyuJhBmIb_hf0GczahAw</recordid><startdate>20200706</startdate><enddate>20200706</enddate><creator>San-Juan, Rafael</creator><creator>Fernández-Ruiz, Mario</creator><creator>Ruiz-Ruigómez, María</creator><creator>López-Medrano, Francisco</creator><creator>Ruiz-Merlo, Tamara</creator><creator>Andrés, Amado</creator><creator>Loinaz, Carmelo</creator><creator>Len, Oscar</creator><creator>Azancot, María Antonieta</creator><creator>Montejo, Miguel</creator><creator>Rodriguez-Alvarez, Regino</creator><creator>Fortún, Jesús</creator><creator>Escudero-Sánchez, Rosa</creator><creator>Giménez, Estela</creator><creator>Lora, David</creator><creator>Albert, Eliseo</creator><creator>Navarro, David</creator><creator>Aguado, José María</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3446-1991</orcidid></search><sort><creationdate>20200706</creationdate><title>A New Clinical and Immunovirological Score for Predicting the Risk of Late Severe Infection in Solid Organ Transplant Recipients: The CLIV Score</title><author>San-Juan, Rafael ; Fernández-Ruiz, Mario ; Ruiz-Ruigómez, María ; López-Medrano, Francisco ; Ruiz-Merlo, Tamara ; Andrés, Amado ; Loinaz, Carmelo ; Len, Oscar ; Azancot, María Antonieta ; Montejo, Miguel ; Rodriguez-Alvarez, Regino ; Fortún, Jesús ; Escudero-Sánchez, Rosa ; Giménez, Estela ; Lora, David ; Albert, Eliseo ; Navarro, David ; Aguado, José María</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-adc076e6d7be26fb2af7fcfdb9b4af345ea622bbb66a435d1162eae14875b2b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cytomegalovirus</topic><topic>DNA, Viral - blood</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - diagnosis</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Female</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunosuppression</topic><topic>Infections</topic><topic>Kidney transplantation</topic><topic>Leukocyte Count</topic><topic>Liver transplantation</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Opportunistic Infections - etiology</topic><topic>Organ Transplantation - adverse effects</topic><topic>Peripheral blood</topic><topic>Postoperative Complications - etiology</topic><topic>Recurrent infection</topic><topic>ROC Curve</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>San-Juan, Rafael</creatorcontrib><creatorcontrib>Fernández-Ruiz, Mario</creatorcontrib><creatorcontrib>Ruiz-Ruigómez, María</creatorcontrib><creatorcontrib>López-Medrano, Francisco</creatorcontrib><creatorcontrib>Ruiz-Merlo, Tamara</creatorcontrib><creatorcontrib>Andrés, Amado</creatorcontrib><creatorcontrib>Loinaz, Carmelo</creatorcontrib><creatorcontrib>Len, Oscar</creatorcontrib><creatorcontrib>Azancot, María Antonieta</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Rodriguez-Alvarez, Regino</creatorcontrib><creatorcontrib>Fortún, Jesús</creatorcontrib><creatorcontrib>Escudero-Sánchez, Rosa</creatorcontrib><creatorcontrib>Giménez, Estela</creatorcontrib><creatorcontrib>Lora, David</creatorcontrib><creatorcontrib>Albert, Eliseo</creatorcontrib><creatorcontrib>Navarro, David</creatorcontrib><creatorcontrib>Aguado, José María</creatorcontrib><creatorcontrib>Spanish Network for Research in Infectious Diseases (Red Española de Investigación en Patología Infecciosa [REIPI] RD16/0016)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>San-Juan, Rafael</au><au>Fernández-Ruiz, Mario</au><au>Ruiz-Ruigómez, María</au><au>López-Medrano, Francisco</au><au>Ruiz-Merlo, Tamara</au><au>Andrés, Amado</au><au>Loinaz, Carmelo</au><au>Len, Oscar</au><au>Azancot, María Antonieta</au><au>Montejo, Miguel</au><au>Rodriguez-Alvarez, Regino</au><au>Fortún, Jesús</au><au>Escudero-Sánchez, Rosa</au><au>Giménez, Estela</au><au>Lora, David</au><au>Albert, Eliseo</au><au>Navarro, David</au><au>Aguado, José María</au><aucorp>Spanish Network for Research in Infectious Diseases (Red Española de Investigación en Patología Infecciosa [REIPI] RD16/0016)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Clinical and Immunovirological Score for Predicting the Risk of Late Severe Infection in Solid Organ Transplant Recipients: The CLIV Score</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2020-07-06</date><risdate>2020</risdate><volume>222</volume><issue>3</issue><spage>479</spage><epage>487</epage><pages>479-487</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Background
We aimed at constructing a composite score based on Epstein-Barr virus DNAemia (EBVd) and simple clinical and immunological parameters to predict late severe infection (LI) beyond month 6 in solid organ transplantation (SOT) recipients.
Methods
Kidney and liver transplant recipients between May 2014 and August 2016 at 4 participating centers were included. Serum immunoglobulins and complement factors, peripheral blood lymphocyte subpopulations, and whole blood EBVd were determined at months 1, 3, and 6. Cox regression analyses were performed to generate a weighted score for the prediction of LI.
Results
Overall, 309 SOT recipients were followed-up for a median of 1000 days from transplant (interquartile range, 822–1124). Late severe infection occurred in 104 patients (33.6%). The CLIV Score consisted of the following variables at month 6: high-level EBVd (>1500 IU/mL) and recurrent infection during the previous months (6 points); recipient age ≥70 years and chronic graft dysfunction (5 points); cytomegalovirus mismatch (4 points); and CD8+ T-cell count <400 cells/μL (2 points). The area under receiver operating characteristics curve was 0.77 (95% confidence interval, 0.71–0.84). The risk of LI at day 1000 was as follows: score 0, 12.6%; score 2–5, 25.5%; score 6–9, 52.7%; score ≥10, 73.5%.
Conclusions
While waiting for further external validation, the CLIV Score based on clinical and immune-virological parameters is potentially useful to stratify the risk of LI after SOT.
The CLIV Score consisted of the following variables at month 6: high-level EBVd and recurrent infection during the previous months; recipient age ≥70 years and chronic graft dysfunction; CMV mismatch; and CD8+ T-cell count <400 cells/μL.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32112085</pmid><doi>10.1093/infdis/jiaa090</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3446-1991</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2020-07, Vol.222 (3), p.479-487 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2369439151 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged CD8 antigen CD8-Positive T-Lymphocytes - immunology Cytomegalovirus DNA, Viral - blood Epstein-Barr virus Epstein-Barr Virus Infections - diagnosis Epstein-Barr Virus Infections - virology Female Herpesvirus 4, Human - isolation & purification Humans Immunoglobulins Immunosuppression Infections Kidney transplantation Leukocyte Count Liver transplantation Lymphocytes T Male Middle Aged Multivariate Analysis Opportunistic Infections - etiology Organ Transplantation - adverse effects Peripheral blood Postoperative Complications - etiology Recurrent infection ROC Curve Transplants & implants |
| title | A New Clinical and Immunovirological Score for Predicting the Risk of Late Severe Infection in Solid Organ Transplant Recipients: The CLIV Score |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T17%3A08%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20New%20Clinical%20and%20Immunovirological%20Score%20for%20Predicting%20the%20Risk%20of%20Late%20Severe%20Infection%20in%20Solid%20Organ%20Transplant%20Recipients:%20The%20CLIV%20Score&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=San-Juan,%20Rafael&rft.aucorp=Spanish%20Network%20for%20Research%20in%20Infectious%20Diseases%20(Red%20Espa%C3%B1ola%20de%20Investigaci%C3%B3n%20en%20Patolog%C3%ADa%20Infecciosa%20%5BREIPI%5D%20RD16/0016)&rft.date=2020-07-06&rft.volume=222&rft.issue=3&rft.spage=479&rft.epage=487&rft.pages=479-487&rft.issn=0022-1899&rft.eissn=1537-6613&rft_id=info:doi/10.1093/infdis/jiaa090&rft_dat=%3Cproquest_cross%3E2473810145%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2473810145&rft_id=info:pmid/32112085&rft_oup_id=10.1093/infdis/jiaa090&rfr_iscdi=true |