Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy

•MiR-219 and NMDA-NR1 expressions are inverse both for amygdala and hippocampus.•NR1 and GluR2 were upregulated in the amygdala of patients with epilepsy.•MiR-219 may play a regulatory role in excitatory neurotransmission in epilepsy. Mesial temporal lobe epilepsy with hippocampal sclerosis is the m...

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Veröffentlicht in:	Journal of clinical neuroscience 2020-04, Vol.74, p.180-186
Hauptverfasser:	Hamamoto, Osmi, Tirapelli, Daniela Pretti da Cunha, Lizarte Neto, Fermino Sanches, Freitas-Lima, Priscila, Saggioro, Fabiano Pinto, Cirino, Mucio Luiz de Assis, Assirati Jr, João Alberto, Serafini, Luciano Neder, Velasco, Tonicarlo Rodrigues, Sakamoto, Américo Ceiki, Carlotti Jr, Carlos Gilberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala GABAA receptors Glutamate receptors Hippocampus MicroRNA Temporal lobe epilepsy
Online-Zugang:	Volltext
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