Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells

Tyrosine kinase inhibitor (TKI) resistance is a major problem in chronic myeloid leukemia (CML). We generated a TKI-resistant K562 sub-population, K562-IR, under selective imatinib-mesylate pressure. K562-IR cells are CD34(-)/CD38(-), BCR-Abl-independent, proliferate slowly, highly adherent and form...

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Veröffentlicht in:	PloS one 2020-02, Vol.15 (2), p.e0229104-e0229104, Article 0229104
Hauptverfasser:	Baykal-Kose, Seda, Acikgoz, Eda, Yavuz, Ahmet Sinan, Geyik, Oyku Gonul, Ate, Halil, Sezerman, Osman Ugur, Ozsan, Guner Hayri, Yuce, Zeynep
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Abl protein Analysis Animals Antigens, CD - genetics Antigens, CD - metabolism Apoptosis BCR protein BCR-ABL protein Biology Biology and Life Sciences Bosutinib Cadherins - genetics Cadherins - metabolism Cancer CD34 antigen CD38 antigen CD44 antigen CD45 antigen Cell Proliferation - drug effects Cell Proliferation - genetics Chromosomes Chronic myeloid leukemia Drug dosages Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics E-cadherin Embryology Environmental stress Enzyme inhibitors Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Fusion protein Fusion Proteins, bcr-abl - antagonists & inhibitors Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Genes Genotype & phenotype Hematology Histology Humans Imatinib Imatinib Mesylate - pharmacology Imatinib Mesylate - therapeutic use K562 Cells Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Medicine Medicine and Health Sciences Mice Multidisciplinary Sciences Mutation Mutation - drug effects Myeloid leukemia Oligonucleotide Array Sequence Analysis Penicillin G Phenols (Class of compounds) Phenotypes Ponatinib Protein Domains - genetics Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Proteins Research and Analysis Methods Science & Technology Science & Technology - Other Topics Senescence Spheroids Stem cell transplantation Stem cells Transcription Transcription (Genetics) Tumors Tyrosine β-Catenin
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