Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study
Abstract Background Human rhinoviruses (HRVs), human enteroviruses (HEVs) and human parechoviruses (HPeVs) have been linked to acute otitis media (AOM). We evaluated this association in a prospective birth cohort setting. Methods A total of 324 healthy infants were followed up from birth to age 3 ye...
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| Veröffentlicht in: | The Journal of infectious diseases 2020-06, Vol.222 (2), p.324-332 |
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| creator | Seppälä, Elina M Oikarinen, Sami Lehtonen, Jussi P Neupane, Subas Honkanen, Hanna Tyni, Iiris Siljander, Heli Ilonen, Jorma Sillanpää, Saara Laranne, Jussi Knip, Mikael Hyöty, Heikki |
| description | Abstract
Background
Human rhinoviruses (HRVs), human enteroviruses (HEVs) and human parechoviruses (HPeVs) have been linked to acute otitis media (AOM). We evaluated this association in a prospective birth cohort setting.
Methods
A total of 324 healthy infants were followed up from birth to age 3 years. Nasal swab samples were collected at age 3, 6, 12, 18, 24, and 36 months and screened for HRV and HEV using real-time reverse-transcription quantitative polymerase chain reaction. Stool samples were collected monthly and analyzed for HRV, HEV, and HPeV. AOM episodes diagnosed by physicians were reported by parents in a diary. The association of viruses with AOM was analyzed using generalized estimation equations, and their relative contributions using population-attributable risk percentages.
Results
A clear association was found between AOM episodes and simultaneous detection of HEV (adjusted odds ratio for the detection of virus in stools, 2.04; 95% confidence interval, 1.06–3.91) and HRV (1.54; 1.04–2.30). HPeV showed a similar, yet nonsignificant trend (adjusted odds ratio, 1.44; 95% confidence interval, .81–2.56). HRV and HEV showed higher population-attributable risk percentages (25% and 20%) than HPeV (11%).
Conclusions
HEVs and HRVs may contribute to the development of AOM in a relatively large proportion of cases.
Human rhinoviruses and human enteroviruses are associated with acute otitis media (AOM) in young children and may contribute to the development of AOM in a relatively large proportion of cases. |
| doi_str_mv | 10.1093/infdis/jiaa087 |
| format | Article |
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Background
Human rhinoviruses (HRVs), human enteroviruses (HEVs) and human parechoviruses (HPeVs) have been linked to acute otitis media (AOM). We evaluated this association in a prospective birth cohort setting.
Methods
A total of 324 healthy infants were followed up from birth to age 3 years. Nasal swab samples were collected at age 3, 6, 12, 18, 24, and 36 months and screened for HRV and HEV using real-time reverse-transcription quantitative polymerase chain reaction. Stool samples were collected monthly and analyzed for HRV, HEV, and HPeV. AOM episodes diagnosed by physicians were reported by parents in a diary. The association of viruses with AOM was analyzed using generalized estimation equations, and their relative contributions using population-attributable risk percentages.
Results
A clear association was found between AOM episodes and simultaneous detection of HEV (adjusted odds ratio for the detection of virus in stools, 2.04; 95% confidence interval, 1.06–3.91) and HRV (1.54; 1.04–2.30). HPeV showed a similar, yet nonsignificant trend (adjusted odds ratio, 1.44; 95% confidence interval, .81–2.56). HRV and HEV showed higher population-attributable risk percentages (25% and 20%) than HPeV (11%).
Conclusions
HEVs and HRVs may contribute to the development of AOM in a relatively large proportion of cases.
Human rhinoviruses and human enteroviruses are associated with acute otitis media (AOM) in young children and may contribute to the development of AOM in a relatively large proportion of cases.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiaa087</identifier><identifier>PMID: 32108877</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Acute Disease ; Child, Preschool ; Cohort analysis ; Confidence intervals ; Ear diseases ; Enterovirus - isolation & purification ; Enterovirus Infections - complications ; Enterovirus Infections - virology ; Feces - virology ; Female ; Humans ; Infant ; Infants ; Male ; Nose - virology ; Otitis media ; Otitis Media - virology ; Parechovirus - isolation & purification ; Picornaviridae Infections - complications ; Picornaviridae Infections - virology ; Polymerase chain reaction ; Prospective Studies ; Rhinovirus ; Rhinovirus - isolation & purification</subject><ispartof>The Journal of infectious diseases, 2020-06, Vol.222 (2), p.324-332</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-f92d026d448641f52ce95bd86422e3def41439f4ab7e572d5de7b819a75b03893</citedby><cites>FETCH-LOGICAL-c397t-f92d026d448641f52ce95bd86422e3def41439f4ab7e572d5de7b819a75b03893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32108877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seppälä, Elina M</creatorcontrib><creatorcontrib>Oikarinen, Sami</creatorcontrib><creatorcontrib>Lehtonen, Jussi P</creatorcontrib><creatorcontrib>Neupane, Subas</creatorcontrib><creatorcontrib>Honkanen, Hanna</creatorcontrib><creatorcontrib>Tyni, Iiris</creatorcontrib><creatorcontrib>Siljander, Heli</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Sillanpää, Saara</creatorcontrib><creatorcontrib>Laranne, Jussi</creatorcontrib><creatorcontrib>Knip, Mikael</creatorcontrib><creatorcontrib>Hyöty, Heikki</creatorcontrib><title>Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Background
Human rhinoviruses (HRVs), human enteroviruses (HEVs) and human parechoviruses (HPeVs) have been linked to acute otitis media (AOM). We evaluated this association in a prospective birth cohort setting.
Methods
A total of 324 healthy infants were followed up from birth to age 3 years. Nasal swab samples were collected at age 3, 6, 12, 18, 24, and 36 months and screened for HRV and HEV using real-time reverse-transcription quantitative polymerase chain reaction. Stool samples were collected monthly and analyzed for HRV, HEV, and HPeV. AOM episodes diagnosed by physicians were reported by parents in a diary. The association of viruses with AOM was analyzed using generalized estimation equations, and their relative contributions using population-attributable risk percentages.
Results
A clear association was found between AOM episodes and simultaneous detection of HEV (adjusted odds ratio for the detection of virus in stools, 2.04; 95% confidence interval, 1.06–3.91) and HRV (1.54; 1.04–2.30). HPeV showed a similar, yet nonsignificant trend (adjusted odds ratio, 1.44; 95% confidence interval, .81–2.56). HRV and HEV showed higher population-attributable risk percentages (25% and 20%) than HPeV (11%).
Conclusions
HEVs and HRVs may contribute to the development of AOM in a relatively large proportion of cases.
Human rhinoviruses and human enteroviruses are associated with acute otitis media (AOM) in young children and may contribute to the development of AOM in a relatively large proportion of cases.</description><subject>Acute Disease</subject><subject>Child, Preschool</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Ear diseases</subject><subject>Enterovirus - isolation & purification</subject><subject>Enterovirus Infections - complications</subject><subject>Enterovirus Infections - virology</subject><subject>Feces - virology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Male</subject><subject>Nose - virology</subject><subject>Otitis media</subject><subject>Otitis Media - virology</subject><subject>Parechovirus - isolation & purification</subject><subject>Picornaviridae Infections - complications</subject><subject>Picornaviridae Infections - virology</subject><subject>Polymerase chain reaction</subject><subject>Prospective Studies</subject><subject>Rhinovirus</subject><subject>Rhinovirus - isolation & purification</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEURoMoWqtblxJwo4uxec1ksqzFR6HSgorLITNJaEo7qUmm0H9vSqsLN64ul3vuB98B4Aqje4wEHdjWKBsGCyslKvkR6OGc8qwoMD0GPYQIyXApxBk4D2GBEGK04KfgjBKMypLzHqiHIbjGymhdC52BM9s438qN9V2A49boZncJ8NPGORw2XdRwGm20Ab5qZSW0LZRw5l1Y78iNhg_WJ3Lk5s5H-BY7tb0AJ0Yug748zD74eHp8H71kk-nzeDScZA0VPGZGEIVIoRgrC4ZNThot8lqlhRBNlTYMMyoMkzXXOScqV5rXJRaS5zWipaB9cLvPXXv31ekQq5UNjV4uZatdFypCC8EI5iVJ6M0fdOG6VHuZKMYEJoImj31wv6ea1C94baq1tyvptxVG1c5-tbdfHeynh-tDbFevtPrFf3Qn4G4PuG79X9g37b2QQg</recordid><startdate>20200629</startdate><enddate>20200629</enddate><creator>Seppälä, Elina M</creator><creator>Oikarinen, Sami</creator><creator>Lehtonen, Jussi P</creator><creator>Neupane, Subas</creator><creator>Honkanen, Hanna</creator><creator>Tyni, Iiris</creator><creator>Siljander, Heli</creator><creator>Ilonen, Jorma</creator><creator>Sillanpää, Saara</creator><creator>Laranne, Jussi</creator><creator>Knip, Mikael</creator><creator>Hyöty, Heikki</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20200629</creationdate><title>Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study</title><author>Seppälä, Elina M ; Oikarinen, Sami ; Lehtonen, Jussi P ; Neupane, Subas ; Honkanen, Hanna ; Tyni, Iiris ; Siljander, Heli ; Ilonen, Jorma ; Sillanpää, Saara ; Laranne, Jussi ; Knip, Mikael ; Hyöty, Heikki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-f92d026d448641f52ce95bd86422e3def41439f4ab7e572d5de7b819a75b03893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Disease</topic><topic>Child, Preschool</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>Ear diseases</topic><topic>Enterovirus - isolation & purification</topic><topic>Enterovirus Infections - complications</topic><topic>Enterovirus Infections - virology</topic><topic>Feces - virology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Male</topic><topic>Nose - virology</topic><topic>Otitis media</topic><topic>Otitis Media - virology</topic><topic>Parechovirus - isolation & purification</topic><topic>Picornaviridae Infections - complications</topic><topic>Picornaviridae Infections - virology</topic><topic>Polymerase chain reaction</topic><topic>Prospective Studies</topic><topic>Rhinovirus</topic><topic>Rhinovirus - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seppälä, Elina M</creatorcontrib><creatorcontrib>Oikarinen, Sami</creatorcontrib><creatorcontrib>Lehtonen, Jussi P</creatorcontrib><creatorcontrib>Neupane, Subas</creatorcontrib><creatorcontrib>Honkanen, Hanna</creatorcontrib><creatorcontrib>Tyni, Iiris</creatorcontrib><creatorcontrib>Siljander, Heli</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Sillanpää, Saara</creatorcontrib><creatorcontrib>Laranne, Jussi</creatorcontrib><creatorcontrib>Knip, Mikael</creatorcontrib><creatorcontrib>Hyöty, Heikki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seppälä, Elina M</au><au>Oikarinen, Sami</au><au>Lehtonen, Jussi P</au><au>Neupane, Subas</au><au>Honkanen, Hanna</au><au>Tyni, Iiris</au><au>Siljander, Heli</au><au>Ilonen, Jorma</au><au>Sillanpää, Saara</au><au>Laranne, Jussi</au><au>Knip, Mikael</au><au>Hyöty, Heikki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2020-06-29</date><risdate>2020</risdate><volume>222</volume><issue>2</issue><spage>324</spage><epage>332</epage><pages>324-332</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Background
Human rhinoviruses (HRVs), human enteroviruses (HEVs) and human parechoviruses (HPeVs) have been linked to acute otitis media (AOM). We evaluated this association in a prospective birth cohort setting.
Methods
A total of 324 healthy infants were followed up from birth to age 3 years. Nasal swab samples were collected at age 3, 6, 12, 18, 24, and 36 months and screened for HRV and HEV using real-time reverse-transcription quantitative polymerase chain reaction. Stool samples were collected monthly and analyzed for HRV, HEV, and HPeV. AOM episodes diagnosed by physicians were reported by parents in a diary. The association of viruses with AOM was analyzed using generalized estimation equations, and their relative contributions using population-attributable risk percentages.
Results
A clear association was found between AOM episodes and simultaneous detection of HEV (adjusted odds ratio for the detection of virus in stools, 2.04; 95% confidence interval, 1.06–3.91) and HRV (1.54; 1.04–2.30). HPeV showed a similar, yet nonsignificant trend (adjusted odds ratio, 1.44; 95% confidence interval, .81–2.56). HRV and HEV showed higher population-attributable risk percentages (25% and 20%) than HPeV (11%).
Conclusions
HEVs and HRVs may contribute to the development of AOM in a relatively large proportion of cases.
Human rhinoviruses and human enteroviruses are associated with acute otitis media (AOM) in young children and may contribute to the development of AOM in a relatively large proportion of cases.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32108877</pmid><doi>10.1093/infdis/jiaa087</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Acute Disease Child, Preschool Cohort analysis Confidence intervals Ear diseases Enterovirus - isolation & purification Enterovirus Infections - complications Enterovirus Infections - virology Feces - virology Female Humans Infant Infants Male Nose - virology Otitis media Otitis Media - virology Parechovirus - isolation & purification Picornaviridae Infections - complications Picornaviridae Infections - virology Polymerase chain reaction Prospective Studies Rhinovirus Rhinovirus - isolation & purification |
| title | Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study |
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