Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation

ER aminopeptidase 1 (ERAP1) is an intracellular enzyme that generates antigenic peptides and is an emerging target for cancer immunotherapy and the control of autoimmunity. ERAP1 inhibitors described previously target the active site and are limited in selectivity, minimizing their clinical potentia...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-03, Vol.63 (6), p.3348-3358
Hauptverfasser:	Liddle, John, Hutchinson, Jonathan P, Kitchen, Semra, Rowland, Paul, Neu, Margarete, Cecconie, Ted, Holmes, Duncan S, Jones, Emma, Korczynska, Justyna, Koumantou, Despoina, Lea, Jonathan D, Nickels, Leng, Pemberton, Michelle, Phillipou, Alex, Schneck, Jessica L, Sheehan, Hester, Tinworth, Christopher P, Uings, Iain, Wojno-Picon, Justyna, Young, Robert J, Stratikos, Efstratios
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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