Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand

The adverse side effects and acquired resistance associated with the clinical application of traditional platinum-based anticancer drugs have forced investigation of alternative transition metal-based compounds and their cytostatic properties. Over the last years, the anticancer potential of cobalt...

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Veröffentlicht in:	Journal of biological inorganic chemistry 2020-03, Vol.25 (2), p.339-350
Hauptverfasser:	Crlikova, Hana, Kostrhunova, Hana, Pracharova, Jitka, Kozsup, Máté, Nagy, Sándor, Buglyó, Péter, Brabec, Viktor, Kasparkova, Jana
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones - chemistry Anthraquinones - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic drugs Antitumor agents Binding Sites - drug effects Biochemistry Biomedical and Life Sciences Cancer Cell Proliferation - drug effects Cobalt Cobalt - chemistry Cobalt - pharmacology Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Deoxyribonucleic acid DNA DNA - chemistry DNA Cleavage Drug Screening Assays, Antitumor Humans Life Sciences Ligands Microbiology Molecular Conformation Original Paper Platinum Quinizarin Redox properties Tumor cells Tumor Cells, Cultured
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