A possible role for hepcidin in the detection of iron deficiency in severely anaemic HIV-infected patients in Malawi

Introduction Iron deficiency is a treatable cause of severe anaemia in low-and-middle-income-countries (LMIC). Diagnosing it remains challenging as peripheral blood markers poorly reflect bone-marrow iron deficiency (BM-ID), especially in the context of HIV-infection. Methods Severely anaemic (haemo...

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Veröffentlicht in:	PloS one 2020-02, Vol.15 (2), p.e0218694-e0218694, Article 0218694
Hauptverfasser:	Huibers, Minke H. W., Calis, Job C., Allain, Theresa J., Coupland, Sarah E., Phiri, Chimota, Phiri, Kamija S., Swinkels, Dorine W., van Hensbroek, Michael Boele, Bates, Imelda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anemia Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - complications Anemia, Iron-Deficiency - diagnosis Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Blood Bone marrow Bone Marrow Cells - metabolism Children & youth Childrens health Cytomegalovirus Evaluation Female Females Ferritin Ferritins - blood Health aspects Hematology Hemoglobin Hemoglobins Hepcidin Hepcidins - blood HIV HIV infections HIV Infections - complications HIV patients Hospitals Human immunodeficiency virus Humans Infections Inflammation Internal medicine Iron Iron - blood Iron deficiency Iron deficiency anemia Laboratories Malawi Male Males Medical care quality Medical research Medical schools Medicine Medicine and Health Sciences Multidisciplinary Sciences Nutrient deficiency Pathology Patients Peripheral blood Receptors, Transferrin - blood Science & Technology Science & Technology - Other Topics Sensitivity Sensitivity and Specificity Transferrin Transferrins Tuberculosis Viral infections
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