Assessment of the nail penetration of antifungal agents, with different physico-chemical properties

Onychomycosis, or fungal nail infection, is a common fungal infection largely caused by dermatophyte fungi, such as Trichophyton rubrum or Trichophyton mentagrophytes, which affects a significant number of people. Treatment is either through oral antifungal medicines, which are efficacious but have...

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Veröffentlicht in:	PloS one 2020-02, Vol.15 (2), p.e0229414-e0229414, Article 0229414
Hauptverfasser:	Davies-Strickleton, Heather, Cook, Julie, Hannam, Sally, Bennett, Rhys, Gibbs, Alan, Edwards, David, Ridden, Christine, Ridden, John, Cook, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Amorolfine Analysis Antifungal agents Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - pharmacokinetics Antifungal Agents - pharmacology Biology and Life Sciences Bubbles Caffeine Chemical properties Dermatophyte fungi Drugs Efinaconazole Fluconazole Fungi Fungicides Health aspects Humans Hydrophilicity Hydrophobic and Hydrophilic Interactions Infection Infections Luliconazole Medicine and Health Sciences Methods Multidisciplinary Sciences Mycoses Mycoses - drug therapy Mycoses - metabolism Mycoses - microbiology Nail Diseases - drug therapy Nail Diseases - metabolism Nail Diseases - microbiology Nails - drug effects Nails - metabolism Nails - microbiology Onychomycosis Organic chemistry Penetration Permeability Physical Sciences Physicochemical properties Purines Safety regulations Science & Technology Science & Technology - Other Topics Tavaborole Terbinafine Tissue Distribution Transdermal drug delivery systems
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