Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells
The cell cycle is a complex and strictly controlled process, consisting of different phases. Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms u...
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| Veröffentlicht in: | Molecular biology reports 2020-04, Vol.47 (4), p.3065-3076 |
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| creator | Caglar, Hasan Onur Biray Avci, Cigir |
| description | The cell cycle is a complex and strictly controlled process, consisting of different phases. Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms underlying the deregulation of the cell cycle have been identified in different types of cancer. Cancer stem cells (CSCs), a fraction of tumor cells, are selectively capable of initiating tumor development. However, the deregulation of the cell cycle progression in CSCs still remains incompletely understood. This review describes epigenetic alterations and aberrant transcriptional regulation of cell cycle genes in CSCs as well as cell cycle patterns of CSCs. |
| doi_str_mv | 10.1007/s11033-020-05341-6 |
| format | Article |
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| subjects | Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cancer Cell cycle Cell Cycle - genetics Cell Cycle - physiology Cell Cycle Checkpoints - genetics Cell Cycle Proteins - genetics Cell Division - genetics Cell Division - physiology Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinases - metabolism Cyclins - genetics Epigenetics Gene regulation Genes, cdc - genetics Histology Humans Life Sciences Morphology Neoplasms - genetics Neoplastic Stem Cells - metabolism Phenotypes Review Stem cells Transcription Tumor cells |
| title | Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells |
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