Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10

DOCK10, a guanine-nucleotide exchange factor (GEF) for Rho GTPases, represents the example of a gene that gives rise to alternative first exon mRNA isoforms, named DOCK10.1 and DOCK10.2. Expression of human DOCK10.2 protein in cell lines, and its induction by interleukin-4 (IL-4) in normal B lymphoc...

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Veröffentlicht in:	Molecular biology reports 2020-04, Vol.47 (4), p.3003-3010
1. Verfasser:	Parrado, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animal Anatomy Animal Biochemistry Animals Antisera Biomedical and Life Sciences Cell Line, Tumor Chronic lymphocytic leukemia Exons Gene expression Guanine Guanine Nucleotide Exchange Factors - biosynthesis Guanine Nucleotide Exchange Factors - blood Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - immunology HEK293 Cells Histology Humans Immune Sera - chemistry Immune Sera - metabolism Interleukin 4 Interleukin-4 - immunology Isoforms Jurkat Cells Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - immunology Life Sciences Lymphatic leukemia Lymphocytes B Lymphocytes T Male Mice Mice, Knockout Morphology Peptides Protein Isoforms Proteins RNA, Messenger - genetics Short Communication Transcription Transcriptome
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