Research on sintering process of tricalcium phosphate bone tissue engineering scaffold based on three-dimensional printing
Tricalcium phosphate (TCP) is one of the most widely used bioceramics for constructing bone tissue engineering scaffold. The three-dimensional (3D) printed TCP scaffold has precise and controllable pore structure, while with the limitation of insufficient mechanical properties. In this study, we inv...
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| Veröffentlicht in: | Sheng wu yi xue gong cheng xue za zhi 2020-02, Vol.37 (1), p.112-118 |
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| container_title | Sheng wu yi xue gong cheng xue za zhi |
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| creator | Man, Xingyun Suo, Hairui Liu, Jiali Xu, Ming'en Wang, Ling |
| description | Tricalcium phosphate (TCP) is one of the most widely used bioceramics for constructing bone tissue engineering scaffold. The three-dimensional (3D) printed TCP scaffold has precise and controllable pore structure, while with the limitation of insufficient mechanical properties. In this study, we investigated the effect of sintering temperature on the mechanical properties of 3D-printed TCP scaffolds in detail, due to the important role of the sintering process on the mechanical properties of bioceramic scaffolds. The morphology, mass and volume shrinkage, porosity, mechanical properties and degradation property of the scaffold was studied. The results showed that the scaffold sintered at 1 150℃ had the maximum volume shrinkage, the minimum porosity and optimal mechanical strength, with the compressive strength of (6.52 ± 0.84) MPa and the compressive modulus of (100.08 ± 18.6) MPa, which could meet the requirements of human cancellous bone. In addition, the 1 150℃ sintered scaffold degraded most slowly in the |
| doi_str_mv | 10.7507/1001-5515.201906065 |
| format | Article |
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The three-dimensional (3D) printed TCP scaffold has precise and controllable pore structure, while with the limitation of insufficient mechanical properties. In this study, we investigated the effect of sintering temperature on the mechanical properties of 3D-printed TCP scaffolds in detail, due to the important role of the sintering process on the mechanical properties of bioceramic scaffolds. The morphology, mass and volume shrinkage, porosity, mechanical properties and degradation property of the scaffold was studied. The results showed that the scaffold sintered at 1 150℃ had the maximum volume shrinkage, the minimum porosity and optimal mechanical strength, with the compressive strength of (6.52 ± 0.84) MPa and the compressive modulus of (100.08 ± 18.6) MPa, which could meet the requirements of human cancellous bone. In addition, the 1 150℃ sintered scaffold degraded most slowly in the</description><identifier>ISSN: 1001-5515</identifier><identifier>DOI: 10.7507/1001-5515.201906065</identifier><identifier>PMID: 32096384</identifier><language>chi</language><publisher>China: Sichuan Society for Biomedical Engineering</publisher><subject>Bioceramics ; Biocompatibility ; Bones ; Calcium phosphates ; Calcium Phosphates - chemistry ; Cancellous bone ; Cell proliferation ; Compressive strength ; Humans ; Implantation ; Materials Testing ; Mechanical properties ; Mesenchyme ; Modulus of elasticity ; Morphology ; Porosity ; Printing, Three-Dimensional ; Scaffolds ; Shrinkage ; Sintering ; Sintering (powder metallurgy) ; Stem cells ; Three dimensional printing ; Tissue Engineering ; Tissue Scaffolds ; Tricalcium phosphate</subject><ispartof>Sheng wu yi xue gong cheng xue za zhi, 2020-02, Vol.37 (1), p.112-118</ispartof><rights>Copyright Sichuan Society for Biomedical Engineering 2020</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32096384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Man, Xingyun</creatorcontrib><creatorcontrib>Suo, Hairui</creatorcontrib><creatorcontrib>Liu, Jiali</creatorcontrib><creatorcontrib>Xu, Ming'en</creatorcontrib><creatorcontrib>Wang, Ling</creatorcontrib><title>Research on sintering process of tricalcium phosphate bone tissue engineering scaffold based on three-dimensional printing</title><title>Sheng wu yi xue gong cheng xue za zhi</title><addtitle>Sheng Wu Yi Xue Gong Cheng Xue Za Zhi</addtitle><description>Tricalcium phosphate (TCP) is one of the most widely used bioceramics for constructing bone tissue engineering scaffold. The three-dimensional (3D) printed TCP scaffold has precise and controllable pore structure, while with the limitation of insufficient mechanical properties. In this study, we investigated the effect of sintering temperature on the mechanical properties of 3D-printed TCP scaffolds in detail, due to the important role of the sintering process on the mechanical properties of bioceramic scaffolds. The morphology, mass and volume shrinkage, porosity, mechanical properties and degradation property of the scaffold was studied. The results showed that the scaffold sintered at 1 150℃ had the maximum volume shrinkage, the minimum porosity and optimal mechanical strength, with the compressive strength of (6.52 ± 0.84) MPa and the compressive modulus of (100.08 ± 18.6) MPa, which could meet the requirements of human cancellous bone. In addition, the 1 150℃ sintered scaffold degraded most slowly in the</description><subject>Bioceramics</subject><subject>Biocompatibility</subject><subject>Bones</subject><subject>Calcium phosphates</subject><subject>Calcium Phosphates - chemistry</subject><subject>Cancellous bone</subject><subject>Cell proliferation</subject><subject>Compressive strength</subject><subject>Humans</subject><subject>Implantation</subject><subject>Materials Testing</subject><subject>Mechanical properties</subject><subject>Mesenchyme</subject><subject>Modulus of elasticity</subject><subject>Morphology</subject><subject>Porosity</subject><subject>Printing, Three-Dimensional</subject><subject>Scaffolds</subject><subject>Shrinkage</subject><subject>Sintering</subject><subject>Sintering (powder metallurgy)</subject><subject>Stem cells</subject><subject>Three dimensional printing</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds</subject><subject>Tricalcium phosphate</subject><issn>1001-5515</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLxDAQx3NQ3GXdTyBIwIuXat5tj7L4ggVB9l7SdLKNtElt2oN-erPs6sHTwPCb_2MQuqLkLpckv6eE0ExKKu8YoSVRRMkztPzbLtA6RlcTwgqiVMEv0IIzUipeiCX6focIejQtDh5H5ycYnd_jYQwGYsTB4ml0RnfGzT0e2hCHVk-A6-ABTy7GGTD4vfNwvItGWxu6Btc6QnPQnNoRIGtcDz664HWXtJNNgi_RudVdhPVprtDu6XG3ecm2b8-vm4dtNhRCZEYyS4EwkcIfOkjOrWC24JaW0iiaW8aFzEHm2kpJgCdclwQKZXgprOUrdHuUTZ0-Z4hT1btooOu0hzDHinEliMgFFQm9-Yd-hHlMmQ9UoXhyZCRR1ydqrntoqtSn1-NX9ftU_gO3IHkr</recordid><startdate>20200225</startdate><enddate>20200225</enddate><creator>Man, Xingyun</creator><creator>Suo, Hairui</creator><creator>Liu, Jiali</creator><creator>Xu, Ming'en</creator><creator>Wang, Ling</creator><general>Sichuan Society for Biomedical Engineering</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20200225</creationdate><title>Research on sintering process of tricalcium phosphate bone tissue engineering scaffold based on three-dimensional printing</title><author>Man, Xingyun ; Suo, Hairui ; Liu, Jiali ; Xu, Ming'en ; Wang, Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p844-c52f1e024806b002533f42f83f195c617f23457e57af550e32f1a90e86c394ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2020</creationdate><topic>Bioceramics</topic><topic>Biocompatibility</topic><topic>Bones</topic><topic>Calcium phosphates</topic><topic>Calcium Phosphates - chemistry</topic><topic>Cancellous bone</topic><topic>Cell proliferation</topic><topic>Compressive strength</topic><topic>Humans</topic><topic>Implantation</topic><topic>Materials Testing</topic><topic>Mechanical properties</topic><topic>Mesenchyme</topic><topic>Modulus of elasticity</topic><topic>Morphology</topic><topic>Porosity</topic><topic>Printing, Three-Dimensional</topic><topic>Scaffolds</topic><topic>Shrinkage</topic><topic>Sintering</topic><topic>Sintering (powder metallurgy)</topic><topic>Stem cells</topic><topic>Three dimensional printing</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds</topic><topic>Tricalcium phosphate</topic><toplevel>online_resources</toplevel><creatorcontrib>Man, Xingyun</creatorcontrib><creatorcontrib>Suo, Hairui</creatorcontrib><creatorcontrib>Liu, Jiali</creatorcontrib><creatorcontrib>Xu, Ming'en</creatorcontrib><creatorcontrib>Wang, Ling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Sheng wu yi xue gong cheng xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Man, Xingyun</au><au>Suo, Hairui</au><au>Liu, Jiali</au><au>Xu, Ming'en</au><au>Wang, Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research on sintering process of tricalcium phosphate bone tissue engineering scaffold based on three-dimensional printing</atitle><jtitle>Sheng wu yi xue gong cheng xue za zhi</jtitle><addtitle>Sheng Wu Yi Xue Gong Cheng Xue Za Zhi</addtitle><date>2020-02-25</date><risdate>2020</risdate><volume>37</volume><issue>1</issue><spage>112</spage><epage>118</epage><pages>112-118</pages><issn>1001-5515</issn><abstract>Tricalcium phosphate (TCP) is one of the most widely used bioceramics for constructing bone tissue engineering scaffold. The three-dimensional (3D) printed TCP scaffold has precise and controllable pore structure, while with the limitation of insufficient mechanical properties. In this study, we investigated the effect of sintering temperature on the mechanical properties of 3D-printed TCP scaffolds in detail, due to the important role of the sintering process on the mechanical properties of bioceramic scaffolds. The morphology, mass and volume shrinkage, porosity, mechanical properties and degradation property of the scaffold was studied. The results showed that the scaffold sintered at 1 150℃ had the maximum volume shrinkage, the minimum porosity and optimal mechanical strength, with the compressive strength of (6.52 ± 0.84) MPa and the compressive modulus of (100.08 ± 18.6) MPa, which could meet the requirements of human cancellous bone. In addition, the 1 150℃ sintered scaffold degraded most slowly in the</abstract><cop>China</cop><pub>Sichuan Society for Biomedical Engineering</pub><pmid>32096384</pmid><doi>10.7507/1001-5515.201906065</doi><tpages>7</tpages></addata></record> |
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| subjects | Bioceramics Biocompatibility Bones Calcium phosphates Calcium Phosphates - chemistry Cancellous bone Cell proliferation Compressive strength Humans Implantation Materials Testing Mechanical properties Mesenchyme Modulus of elasticity Morphology Porosity Printing, Three-Dimensional Scaffolds Shrinkage Sintering Sintering (powder metallurgy) Stem cells Three dimensional printing Tissue Engineering Tissue Scaffolds Tricalcium phosphate |
| title | Research on sintering process of tricalcium phosphate bone tissue engineering scaffold based on three-dimensional printing |
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