AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

Oncogenes can create metabolic vulnerabilities in cancer cells. We tested how AKT (herein referring to AKT1) and MYC affect the ability of cells to shift between respiration and glycolysis. Using immortalized mammary epithelial cells, we discovered that constitutively active AKT, but not MYC, induce...

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Veröffentlicht in:	Journal of cell science 2020-04, Vol.133 (7)
Hauptverfasser:	Zheng, Dongqing, Sussman, Jonathan H, Jeon, Matthew P, Parrish, Sydney T, MacMullan, Melanie A, Delfarah, Alireza, Graham, Nicholas A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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