Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

The process of metastasis is complex 1 . In breast cancer, there are frequently long time intervals between cells leaving the primary tumour and growth of overt metastases 2 , 3 . Reasons for disease indolence and subsequent transition back to aggressive growth include interactions with myeloid and...

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Veröffentlicht in:	Nature cell biology 2020-03, Vol.22 (3), p.289-296
Hauptverfasser:	Montagner, Marco, Bhome, Rahul, Hooper, Steven, Chakravarty, Probir, Qin, Xiao, Sufi, Jahangir, Bhargava, Ajay, Ratcliffe, Colin D. H., Naito, Yutaka, Pocaterra, Arianna, Tape, Christopher J., Sahai, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/1 14/19 14/32 14/35 14/63 38 38/23 45 631/67 631/67/322 692/699/67/1347 692/699/67/327 82 Alveolar Epithelial Cells - physiology Alveoli Animals Biomedical and Life Sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Cell Biology Cell Line Cell Line, Tumor Crosstalk Developmental Biology Diagnosis Epithelial cells Female Fibrillogenesis Fibronectin Frizzled protein Frizzled-related protein Gene sequencing Genetic aspects Genetic regulation Health aspects Humans Latency Letter Life Sciences Lung cancer Lungs Membrane Proteins - physiology Metastases Mice Mice, Nude Neoplasm Metastasis Proto-Oncogene Proteins pp60(c-src) - physiology Ribonucleic acid RNA Secreted frizzled-related protein 2 Signal Transduction Stem Cells Survival Tumor microenvironment Tumors
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