The increased frequency of methicillin-resistant Staphylococcus aureus with low MIC of beta-lactam antibiotics isolated from hospitalized patients
Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infectious diseases and can be life-threatening in healthcare-settings. MRSA is classified into health-care associated (HA)-MRSA strains and community acquired (CA)-MRSA strains based on genotype and phenotype. CA-MRSA has been reporte...
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| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2020-06, Vol.26 (6), p.604-610 |
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| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
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| creator | Iwata, Yasunori Sakai, Norihiko Yoneda, Ikuko Satou, Kenji Furuichi, Kengo Senda, Yasuko Sakai-Takemori, Yukiko Wada, Taizo Fujita, Shinichi Ogura, Hisahiro Sato, Kouichi Minami, Taichiro Yamaguchi, Kaori Kitajima, Shinji Toyama, Tadashi Yamamura, Yuta Miyagawa, Taro Hara, Akinori Shimizu, Miho Sakai, Yoshio Ikeo, Kazuho Shichino, Shigeyuki Ueha, Satoshi Nakajima, Takuya Matsushima, Kouji Wada, Takashi |
| description | Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infectious diseases and can be life-threatening in healthcare-settings. MRSA is classified into health-care associated (HA)-MRSA strains and community acquired (CA)-MRSA strains based on genotype and phenotype. CA-MRSA has been reported to show the lower minimal inhibitory concentration (MIC) of some antibiotics as compared to HA-MRSA. Recently, the prevalence of CA-MRSA has been increased in worldwide. CA-MRSA is isolated not only from the healthy individuals in a community but also from the patients in healthcare settings. However, the changing trend in frequency of HA-MRSA and CA-MRSA in the hospital setting is not clear. Therefore, we analyzed the trend of MIC to speculate the frequency of HA-MRSA and CA-MRSA in the facility. Moreover, gene mutations were evaluated on resistant gene loci with next generation sequencer. The frequency of strains with low MIC of beta-lactam antibiotics was gradually increased in isolated MRSA strains from the hospitalized patients. Whole genome analysis revealed the frequency of gene mutation was also decreased in some resistant loci, such as blaZ and blaR1. These findings highlight the changing trend of MRSA strains isolated from hospitalized patients. |
| doi_str_mv | 10.1016/j.jiac.2020.01.016 |
| format | Article |
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MRSA is classified into health-care associated (HA)-MRSA strains and community acquired (CA)-MRSA strains based on genotype and phenotype. CA-MRSA has been reported to show the lower minimal inhibitory concentration (MIC) of some antibiotics as compared to HA-MRSA. Recently, the prevalence of CA-MRSA has been increased in worldwide. CA-MRSA is isolated not only from the healthy individuals in a community but also from the patients in healthcare settings. However, the changing trend in frequency of HA-MRSA and CA-MRSA in the hospital setting is not clear. Therefore, we analyzed the trend of MIC to speculate the frequency of HA-MRSA and CA-MRSA in the facility. Moreover, gene mutations were evaluated on resistant gene loci with next generation sequencer. The frequency of strains with low MIC of beta-lactam antibiotics was gradually increased in isolated MRSA strains from the hospitalized patients. Whole genome analysis revealed the frequency of gene mutation was also decreased in some resistant loci, such as blaZ and blaR1. These findings highlight the changing trend of MRSA strains isolated from hospitalized patients.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1016/j.jiac.2020.01.016</identifier><identifier>PMID: 32094050</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - pharmacology ; Bacterial Proteins - genetics ; beta-Lactamases - genetics ; beta-Lactams - pharmacology ; CA-MRSA ; Community-Acquired Infections - diagnosis ; Community-Acquired Infections - microbiology ; Cross Infection - diagnosis ; Cross Infection - microbiology ; DNA, Bacterial ; Drug Resistance, Multiple, Bacterial - genetics ; Female ; Genotype ; Humans ; Japan ; Male ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Microbial Sensitivity Tests - trends ; Middle Aged ; MRSA ; Mutation ; Prevalence ; Protein Structure, Tertiary - genetics ; Staphylococcal Infections - diagnosis ; Whole Genome Sequencing</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2020-06, Vol.26 (6), p.604-610</ispartof><rights>2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><rights>Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. 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MRSA is classified into health-care associated (HA)-MRSA strains and community acquired (CA)-MRSA strains based on genotype and phenotype. CA-MRSA has been reported to show the lower minimal inhibitory concentration (MIC) of some antibiotics as compared to HA-MRSA. Recently, the prevalence of CA-MRSA has been increased in worldwide. CA-MRSA is isolated not only from the healthy individuals in a community but also from the patients in healthcare settings. However, the changing trend in frequency of HA-MRSA and CA-MRSA in the hospital setting is not clear. Therefore, we analyzed the trend of MIC to speculate the frequency of HA-MRSA and CA-MRSA in the facility. Moreover, gene mutations were evaluated on resistant gene loci with next generation sequencer. The frequency of strains with low MIC of beta-lactam antibiotics was gradually increased in isolated MRSA strains from the hospitalized patients. Whole genome analysis revealed the frequency of gene mutation was also decreased in some resistant loci, such as blaZ and blaR1. 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MRSA is classified into health-care associated (HA)-MRSA strains and community acquired (CA)-MRSA strains based on genotype and phenotype. CA-MRSA has been reported to show the lower minimal inhibitory concentration (MIC) of some antibiotics as compared to HA-MRSA. Recently, the prevalence of CA-MRSA has been increased in worldwide. CA-MRSA is isolated not only from the healthy individuals in a community but also from the patients in healthcare settings. However, the changing trend in frequency of HA-MRSA and CA-MRSA in the hospital setting is not clear. Therefore, we analyzed the trend of MIC to speculate the frequency of HA-MRSA and CA-MRSA in the facility. Moreover, gene mutations were evaluated on resistant gene loci with next generation sequencer. The frequency of strains with low MIC of beta-lactam antibiotics was gradually increased in isolated MRSA strains from the hospitalized patients. Whole genome analysis revealed the frequency of gene mutation was also decreased in some resistant loci, such as blaZ and blaR1. These findings highlight the changing trend of MRSA strains isolated from hospitalized patients.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>32094050</pmid><doi>10.1016/j.jiac.2020.01.016</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2020-06, Vol.26 (6), p.604-610 |
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| subjects | Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics beta-Lactamases - genetics beta-Lactams - pharmacology CA-MRSA Community-Acquired Infections - diagnosis Community-Acquired Infections - microbiology Cross Infection - diagnosis Cross Infection - microbiology DNA, Bacterial Drug Resistance, Multiple, Bacterial - genetics Female Genotype Humans Japan Male Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbial Sensitivity Tests - trends Middle Aged MRSA Mutation Prevalence Protein Structure, Tertiary - genetics Staphylococcal Infections - diagnosis Whole Genome Sequencing |
| title | The increased frequency of methicillin-resistant Staphylococcus aureus with low MIC of beta-lactam antibiotics isolated from hospitalized patients |
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