Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors

The upregulation of the protein myeloid cell leukemia-1 (Mcl-1) is closely associated with various human cancers, which can result in the evasion of apoptosis and a low survival rate. Therefore, developing Mcl-1 inhibitors has become a promising paradigm for cancer therapy. Herein, we designed and s...

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Veröffentlicht in:	European journal of medicinal chemistry 2020-04, Vol.191, p.112142-112142, Article 112142
Hauptverfasser:	Liu, Lulu, Liu, Renshuai, Yang, Xinying, Hou, Xuben, Fang, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Mcl-1 inhibitors Tyrosine derivatives
Online-Zugang:	Volltext
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