The Association Between Biomarkers and Neuropsychiatric Symptoms Across the Alzheimer's Disease Spectrum

•To relate Alzheimer's disease (AD) biomarkers with neuropsychiatric symptoms.•AD biomarkers were related to the presence of anxiety and apathy, but not with depression, agitation, irritability, and sleep. The associations with anxiety and apathy were mediated by MMSE score.•AD pathology has an...

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Veröffentlicht in:	The American journal of geriatric psychiatry 2020-07, Vol.28 (7), p.735-744
Hauptverfasser:	Banning, Leonie C.P., Ramakers, Inez H.G.B., Köhler, Sebastian, Bron, Esther E., Verhey, Frans R.J., de Deyn, Peter Paul, Claassen, Jurgen A.H.R., Koek, Huiberdina L., Middelkoop, Huub A.M., van der Flier, Wiesje M., van der Lugt, Aad, Aalten, Pauline
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - psychology Alzheimer's disease Alzheimer's disease dementia Amyloid beta-Peptides - cerebrospinal fluid Anxiety - cerebrospinal fluid Anxiety - epidemiology Apathy Biomarkers Biomarkers - cerebrospinal fluid Cognition & reasoning Cognitive Dysfunction - cerebrospinal fluid Cognitive Dysfunction - epidemiology Cognitive Dysfunction - psychology Dementia Disease Progression Female Hippocampus - pathology Humans Irritable Mood - physiology Logistic Models Longitudinal Studies Magnetic Resonance Imaging Male Mental health Middle Aged mild cognitive impairment Netherlands neurocognitive disorders Neurodegeneration Neuropsychiatric symptoms Neuropsychological Tests tau Proteins - cerebrospinal fluid
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