The Hitchhiker’s Guide to Nucleocytoplasmic Trafficking in Neurodegeneration

The widespread nature of nucleocytoplasmic trafficking defects and protein accumulation suggests distinct yet overlapping mechanisms in a variety of neurodegenerative diseases. Detailed understanding of the cellular pathways involved in nucleocytoplasmic transport and its dysregulation are essential...

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Veröffentlicht in:	Neurochemical research 2020-06, Vol.45 (6), p.1306-1327
Hauptverfasser:	Moore, Stephen, Rabichow, Benjamin E., Sattler, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cytoplasm Humans mRNA Neurochemistry Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurology Neurosciences Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism Pathogenesis Protein transport Protein Transport - physiology Proteins Review Article RNA-binding protein Structure-function relationships Tau protein
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