Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing

As components of the Mediterranean diet (MedDiet) olive polyphenols may play a crucial role for the prevention of Alzheimer's disease (AD). Since mitochondrial dysfunction is involved in both, brain ageing and early AD, effects of 10 different purified phenolic secoiridoids (hydroxytyrosol, tyr...

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Veröffentlicht in:	Experimental neurology 2020-06, Vol.328, p.113248-113248, Article 113248
Hauptverfasser:	Grewal, Rekha, Reutzel, Martina, Dilberger, Benjamin, Hein, Hannah, Zotzel, Jens, Marx, Stefan, Tretzel, Joachim, Sarafeddinov, Alla, Fuchs, Christopher, Eckert, Gunter P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing Aging - drug effects Aldehydes - pharmacology Alzheimer Disease - pathology Animals Brain - drug effects Cell Line Cell Respiration - drug effects Cyclopentane Monoterpenes - pharmacology Disease Models, Animal Female Glucosides - pharmacology Humans Mice Mitochondria - drug effects Mitochondrial dysfunction Neurodegeneration Neurons - drug effects Neuroprotective Agents - pharmacology Olive secoiridoids Phenols - pharmacology Pyrans - pharmacology
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