Mechanisms underlying immobilization‐induced muscle pain in rats
Introduction We investigated the mechanisms underlying immobilization‐induced muscle pain in rats. Methods In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and inter...
Gespeichert in:
| Veröffentlicht in: | Muscle & nerve 2020-05, Vol.61 (5), p.662-670 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 670 |
|---|---|
| container_issue | 5 |
| container_start_page | 662 |
| container_title | Muscle & nerve |
| container_volume | 61 |
| creator | Oga, Satoshi Goto, Kyo Sakamoto, Junya Honda, Yuichiro Sasaki, Ryo Ishikawa, Kumiko Kataoka, Hideki Nakano, Jiro Origuchi, Tomoki Okita, Minoru |
| description | Introduction
We investigated the mechanisms underlying immobilization‐induced muscle pain in rats.
Methods
In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and interleukin‐1β (IL‐1β) mRNA expression were examined. An NGF receptor inhibitor was injected intramuscularly to assess the relationship between PPT and NGF levels.
Results
Immobilization resulted in a decrease in PPT and increases in NGF level, C‐fiber density, M1 macrophage number, and IL‐1β mRNA expression. Injection of NGF receptor inhibitor reversed the decrease in PPT.
Discussion
NGF upregulation may be a major contributor to immobilization‐induced muscle pain. The increases in C‐fiber density, M1 macrophage number, and IL‐1β mRNA expression may be related to immobilization‐induced muscle pain. |
| doi_str_mv | 10.1002/mus.26840 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2362079409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2362079409</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4190-1340ab6ce3d20f2a9722ec2f3b97c9c9b0e06a2fa39d70d0d260f6f2cf6873da3</originalsourceid><addsrcrecordid>eNp10E9LwzAcxvEgipvTg29ACl700O2XpEuaow7_wYYHHXgraZJqRpvOZEXmyZfga_SV2NHpQRACuXz4JjwIHWMYYgAyqpowJCxNYAf1MQgeJ2OR7qI-4CSNGRVPPXQQwgIAcMr4PupRAinl43EfXc6MepHOhipEjdPGl2vrniNbVXVuS_suV7Z2Xx-f1ulGGR21T6nSREtpXdQeL1fhEO0VsgzmaHsP0Pz66nFyG0_vb-4mF9NYJVhAjGkCMmfKUE2gIFJwQowiBc0FV0KJHAwwSQpJheagQRMGBSuIKljKqZZ0gM667tLXr40Jq6yyQZmylM7UTcgIZQS4SEC09PQPXdSNd-3vWiUIFoIL0qrzTilfh-BNkS29raRfZxiyzbBZtcluhm3tybbY5JXRv_JnyRaMOvBmS7P-v5TN5g9d8hs30oMc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2392199792</pqid></control><display><type>article</type><title>Mechanisms underlying immobilization‐induced muscle pain in rats</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Oga, Satoshi ; Goto, Kyo ; Sakamoto, Junya ; Honda, Yuichiro ; Sasaki, Ryo ; Ishikawa, Kumiko ; Kataoka, Hideki ; Nakano, Jiro ; Origuchi, Tomoki ; Okita, Minoru</creator><creatorcontrib>Oga, Satoshi ; Goto, Kyo ; Sakamoto, Junya ; Honda, Yuichiro ; Sasaki, Ryo ; Ishikawa, Kumiko ; Kataoka, Hideki ; Nakano, Jiro ; Origuchi, Tomoki ; Okita, Minoru</creatorcontrib><description>Introduction
We investigated the mechanisms underlying immobilization‐induced muscle pain in rats.
Methods
In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and interleukin‐1β (IL‐1β) mRNA expression were examined. An NGF receptor inhibitor was injected intramuscularly to assess the relationship between PPT and NGF levels.
Results
Immobilization resulted in a decrease in PPT and increases in NGF level, C‐fiber density, M1 macrophage number, and IL‐1β mRNA expression. Injection of NGF receptor inhibitor reversed the decrease in PPT.
Discussion
NGF upregulation may be a major contributor to immobilization‐induced muscle pain. The increases in C‐fiber density, M1 macrophage number, and IL‐1β mRNA expression may be related to immobilization‐induced muscle pain.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26840</identifier><identifier>PMID: 32083755</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>C fiber ; Density ; Gastrocnemius muscle ; Gene expression ; Growth factors ; Immobilization ; Inhibitors ; Interleukins ; M1 macrophage ; Macrophages ; Muscle pain ; Muscles ; Nerve growth factor ; NGF ; Pain ; Peripheral nerves ; Receptors ; Skeletal muscle</subject><ispartof>Muscle & nerve, 2020-05, Vol.61 (5), p.662-670</ispartof><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4190-1340ab6ce3d20f2a9722ec2f3b97c9c9b0e06a2fa39d70d0d260f6f2cf6873da3</citedby><cites>FETCH-LOGICAL-c4190-1340ab6ce3d20f2a9722ec2f3b97c9c9b0e06a2fa39d70d0d260f6f2cf6873da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26840$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26840$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32083755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oga, Satoshi</creatorcontrib><creatorcontrib>Goto, Kyo</creatorcontrib><creatorcontrib>Sakamoto, Junya</creatorcontrib><creatorcontrib>Honda, Yuichiro</creatorcontrib><creatorcontrib>Sasaki, Ryo</creatorcontrib><creatorcontrib>Ishikawa, Kumiko</creatorcontrib><creatorcontrib>Kataoka, Hideki</creatorcontrib><creatorcontrib>Nakano, Jiro</creatorcontrib><creatorcontrib>Origuchi, Tomoki</creatorcontrib><creatorcontrib>Okita, Minoru</creatorcontrib><title>Mechanisms underlying immobilization‐induced muscle pain in rats</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction
We investigated the mechanisms underlying immobilization‐induced muscle pain in rats.
Methods
In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and interleukin‐1β (IL‐1β) mRNA expression were examined. An NGF receptor inhibitor was injected intramuscularly to assess the relationship between PPT and NGF levels.
Results
Immobilization resulted in a decrease in PPT and increases in NGF level, C‐fiber density, M1 macrophage number, and IL‐1β mRNA expression. Injection of NGF receptor inhibitor reversed the decrease in PPT.
Discussion
NGF upregulation may be a major contributor to immobilization‐induced muscle pain. The increases in C‐fiber density, M1 macrophage number, and IL‐1β mRNA expression may be related to immobilization‐induced muscle pain.</description><subject>C fiber</subject><subject>Density</subject><subject>Gastrocnemius muscle</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Immobilization</subject><subject>Inhibitors</subject><subject>Interleukins</subject><subject>M1 macrophage</subject><subject>Macrophages</subject><subject>Muscle pain</subject><subject>Muscles</subject><subject>Nerve growth factor</subject><subject>NGF</subject><subject>Pain</subject><subject>Peripheral nerves</subject><subject>Receptors</subject><subject>Skeletal muscle</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10E9LwzAcxvEgipvTg29ACl700O2XpEuaow7_wYYHHXgraZJqRpvOZEXmyZfga_SV2NHpQRACuXz4JjwIHWMYYgAyqpowJCxNYAf1MQgeJ2OR7qI-4CSNGRVPPXQQwgIAcMr4PupRAinl43EfXc6MepHOhipEjdPGl2vrniNbVXVuS_suV7Z2Xx-f1ulGGR21T6nSREtpXdQeL1fhEO0VsgzmaHsP0Pz66nFyG0_vb-4mF9NYJVhAjGkCMmfKUE2gIFJwQowiBc0FV0KJHAwwSQpJheagQRMGBSuIKljKqZZ0gM667tLXr40Jq6yyQZmylM7UTcgIZQS4SEC09PQPXdSNd-3vWiUIFoIL0qrzTilfh-BNkS29raRfZxiyzbBZtcluhm3tybbY5JXRv_JnyRaMOvBmS7P-v5TN5g9d8hs30oMc</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Oga, Satoshi</creator><creator>Goto, Kyo</creator><creator>Sakamoto, Junya</creator><creator>Honda, Yuichiro</creator><creator>Sasaki, Ryo</creator><creator>Ishikawa, Kumiko</creator><creator>Kataoka, Hideki</creator><creator>Nakano, Jiro</creator><creator>Origuchi, Tomoki</creator><creator>Okita, Minoru</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>202005</creationdate><title>Mechanisms underlying immobilization‐induced muscle pain in rats</title><author>Oga, Satoshi ; Goto, Kyo ; Sakamoto, Junya ; Honda, Yuichiro ; Sasaki, Ryo ; Ishikawa, Kumiko ; Kataoka, Hideki ; Nakano, Jiro ; Origuchi, Tomoki ; Okita, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4190-1340ab6ce3d20f2a9722ec2f3b97c9c9b0e06a2fa39d70d0d260f6f2cf6873da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>C fiber</topic><topic>Density</topic><topic>Gastrocnemius muscle</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>Immobilization</topic><topic>Inhibitors</topic><topic>Interleukins</topic><topic>M1 macrophage</topic><topic>Macrophages</topic><topic>Muscle pain</topic><topic>Muscles</topic><topic>Nerve growth factor</topic><topic>NGF</topic><topic>Pain</topic><topic>Peripheral nerves</topic><topic>Receptors</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oga, Satoshi</creatorcontrib><creatorcontrib>Goto, Kyo</creatorcontrib><creatorcontrib>Sakamoto, Junya</creatorcontrib><creatorcontrib>Honda, Yuichiro</creatorcontrib><creatorcontrib>Sasaki, Ryo</creatorcontrib><creatorcontrib>Ishikawa, Kumiko</creatorcontrib><creatorcontrib>Kataoka, Hideki</creatorcontrib><creatorcontrib>Nakano, Jiro</creatorcontrib><creatorcontrib>Origuchi, Tomoki</creatorcontrib><creatorcontrib>Okita, Minoru</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oga, Satoshi</au><au>Goto, Kyo</au><au>Sakamoto, Junya</au><au>Honda, Yuichiro</au><au>Sasaki, Ryo</au><au>Ishikawa, Kumiko</au><au>Kataoka, Hideki</au><au>Nakano, Jiro</au><au>Origuchi, Tomoki</au><au>Okita, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms underlying immobilization‐induced muscle pain in rats</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2020-05</date><risdate>2020</risdate><volume>61</volume><issue>5</issue><spage>662</spage><epage>670</epage><pages>662-670</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Introduction
We investigated the mechanisms underlying immobilization‐induced muscle pain in rats.
Methods
In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and interleukin‐1β (IL‐1β) mRNA expression were examined. An NGF receptor inhibitor was injected intramuscularly to assess the relationship between PPT and NGF levels.
Results
Immobilization resulted in a decrease in PPT and increases in NGF level, C‐fiber density, M1 macrophage number, and IL‐1β mRNA expression. Injection of NGF receptor inhibitor reversed the decrease in PPT.
Discussion
NGF upregulation may be a major contributor to immobilization‐induced muscle pain. The increases in C‐fiber density, M1 macrophage number, and IL‐1β mRNA expression may be related to immobilization‐induced muscle pain.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32083755</pmid><doi>10.1002/mus.26840</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-639X |
| ispartof | Muscle & nerve, 2020-05, Vol.61 (5), p.662-670 |
| issn | 0148-639X 1097-4598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2362079409 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | C fiber Density Gastrocnemius muscle Gene expression Growth factors Immobilization Inhibitors Interleukins M1 macrophage Macrophages Muscle pain Muscles Nerve growth factor NGF Pain Peripheral nerves Receptors Skeletal muscle |
| title | Mechanisms underlying immobilization‐induced muscle pain in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A21%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanisms%20underlying%20immobilization%E2%80%90induced%20muscle%20pain%20in%20rats&rft.jtitle=Muscle%20&%20nerve&rft.au=Oga,%20Satoshi&rft.date=2020-05&rft.volume=61&rft.issue=5&rft.spage=662&rft.epage=670&rft.pages=662-670&rft.issn=0148-639X&rft.eissn=1097-4598&rft_id=info:doi/10.1002/mus.26840&rft_dat=%3Cproquest_cross%3E2362079409%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2392199792&rft_id=info:pmid/32083755&rfr_iscdi=true |