Synthesis, complete NMR assignment and structural study of a steroidal dimer of 17α-ethynyl-5α,10α-estran-17β-ol with diethynylbenzene spacer

[Display omitted] •A phenylene-bridged steroidal dimer with cis A-B ring-fusion was synthesized.•Despite the aliphatic nature of the dimer, a crystalline solid was obtained.•Dispersive interactions and the loci of the hydroxyl groups direct the self-assembly.•Steroidal dimer as a good scaffold in th...

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Veröffentlicht in:	Steroids 2020-05, Vol.157, p.108606-108606, Article 108606
Hauptverfasser:	Aguilar-Valdez, Nancy, Esturau-Escofet, Nuria, González-Antonio, Oscar, Romero-Ávila, Margarita, Flores-Pérez, Blas, Leyva, Marco A., Díaz, David, Santillan, Rosa, Farfán, Norberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylene - analogs & derivatives Acetylene - chemistry Cis-fused steroid Crystallography, X-Ray Hydrophobic-induced self-assembly Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation NMR Steroidal dimer Steroids - chemical synthesis Steroids - chemistry
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