AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats
This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys. We used the ACB to detect the MNP...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2020-02, Vol.15 (5), p.511-525 |
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| creator | Prospero, Andre G Fidelis-de-Oliveira, Patrícia Soares, Guilherme A Miranda, Milena F Pinto, Leonardo A Dos Santos, Daniela C Silva, Vanessa Dos S Zufelato, Nicholas Bakuzis, Andris F Miranda, José Ra |
| description | This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys.
We used the ACB to detect the MNP kidney perfusion
. Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution.
We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved.
This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine. |
| doi_str_mv | 10.2217/nnm-2019-0300 |
| format | Article |
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We used the ACB to detect the MNP kidney perfusion
. Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution.
We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved.
This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2019-0300</identifier><identifier>PMID: 32077357</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Animals ; biomagnetism ; chronic kidney disease ; Contrast agents ; Creatinine ; doxorubicin ; Health care ; Kidney diseases ; Kidneys ; magnetic nanoparticles ; Magnetic resonance imaging ; Metabolism ; nanomedicine ; Nanoparticles ; Physiology ; renal perfusion ; Scintigraphy ; Sensors ; Software ; Urine</subject><ispartof>Nanomedicine (London, England), 2020-02, Vol.15 (5), p.511-525</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Feb 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-65ab5e09917d926603c8e0a75d39b6545dab78a9352bc7f7c9f869dd667486153</citedby><cites>FETCH-LOGICAL-c371t-65ab5e09917d926603c8e0a75d39b6545dab78a9352bc7f7c9f869dd667486153</cites><orcidid>0000-0001-5163-8280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32077357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prospero, Andre G</creatorcontrib><creatorcontrib>Fidelis-de-Oliveira, Patrícia</creatorcontrib><creatorcontrib>Soares, Guilherme A</creatorcontrib><creatorcontrib>Miranda, Milena F</creatorcontrib><creatorcontrib>Pinto, Leonardo A</creatorcontrib><creatorcontrib>Dos Santos, Daniela C</creatorcontrib><creatorcontrib>Silva, Vanessa Dos S</creatorcontrib><creatorcontrib>Zufelato, Nicholas</creatorcontrib><creatorcontrib>Bakuzis, Andris F</creatorcontrib><creatorcontrib>Miranda, José Ra</creatorcontrib><title>AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys.
We used the ACB to detect the MNP kidney perfusion
. Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution.
We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved.
This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine.</description><subject>Animals</subject><subject>biomagnetism</subject><subject>chronic kidney disease</subject><subject>Contrast agents</subject><subject>Creatinine</subject><subject>doxorubicin</subject><subject>Health care</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>magnetic nanoparticles</subject><subject>Magnetic resonance imaging</subject><subject>Metabolism</subject><subject>nanomedicine</subject><subject>Nanoparticles</subject><subject>Physiology</subject><subject>renal perfusion</subject><subject>Scintigraphy</subject><subject>Sensors</subject><subject>Software</subject><subject>Urine</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kD1rHDEQhkVwiB0nZVojcJNGiT5O0qo0h_MBhjRJLbTSbNDlVjpLK_D9-2hzdgqDq5mBZ15mHoQ-MPqJc6Y_pzQTTpkhVFD6Cl0wvRmIMkqc_esFkcNgztHbWneUyoEz-gadC061FlJfoPFmi8eYa6seDkueYSlH7FLAs_udYIkeJ5fywZXe7qHiJWNXK9SKQ37IpY3Rx0RiCs1DwH9iSHDEMe1aWQsubqnv0OvJ7Su8f6yX6NeX25_bb-Tux9fv25s74oVmC1HSjRKoMUwHw5Wiwg9AnZZBmFHJjQxu1IMzQvLR60l7Mw3KhKBU_1gxKS7Rx1PuoeT7BnWxc-xf7fcuQW7VciGN6GKM7uj1M3SXW0n9Oss3g2ZaCb0GkhPlS661wGQPJc6uHC2jdpVvu3y7yrer_M5fPaa2cYbwn36y3QFzAqa2tALVR0ge7GnqG6tLeCH8L8USk8I</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Prospero, Andre G</creator><creator>Fidelis-de-Oliveira, Patrícia</creator><creator>Soares, Guilherme A</creator><creator>Miranda, Milena F</creator><creator>Pinto, Leonardo A</creator><creator>Dos Santos, Daniela C</creator><creator>Silva, Vanessa Dos S</creator><creator>Zufelato, Nicholas</creator><creator>Bakuzis, Andris F</creator><creator>Miranda, José Ra</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5163-8280</orcidid></search><sort><creationdate>20200201</creationdate><title>AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats</title><author>Prospero, Andre G ; Fidelis-de-Oliveira, Patrícia ; Soares, Guilherme A ; Miranda, Milena F ; Pinto, Leonardo A ; Dos Santos, Daniela C ; Silva, Vanessa Dos S ; Zufelato, Nicholas ; Bakuzis, Andris F ; Miranda, José Ra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-65ab5e09917d926603c8e0a75d39b6545dab78a9352bc7f7c9f869dd667486153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>biomagnetism</topic><topic>chronic kidney disease</topic><topic>Contrast agents</topic><topic>Creatinine</topic><topic>doxorubicin</topic><topic>Health care</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>magnetic nanoparticles</topic><topic>Magnetic resonance imaging</topic><topic>Metabolism</topic><topic>nanomedicine</topic><topic>Nanoparticles</topic><topic>Physiology</topic><topic>renal perfusion</topic><topic>Scintigraphy</topic><topic>Sensors</topic><topic>Software</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prospero, Andre G</creatorcontrib><creatorcontrib>Fidelis-de-Oliveira, Patrícia</creatorcontrib><creatorcontrib>Soares, Guilherme A</creatorcontrib><creatorcontrib>Miranda, Milena F</creatorcontrib><creatorcontrib>Pinto, Leonardo A</creatorcontrib><creatorcontrib>Dos Santos, Daniela C</creatorcontrib><creatorcontrib>Silva, Vanessa Dos S</creatorcontrib><creatorcontrib>Zufelato, Nicholas</creatorcontrib><creatorcontrib>Bakuzis, Andris F</creatorcontrib><creatorcontrib>Miranda, José Ra</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prospero, Andre G</au><au>Fidelis-de-Oliveira, Patrícia</au><au>Soares, Guilherme A</au><au>Miranda, Milena F</au><au>Pinto, Leonardo A</au><au>Dos Santos, Daniela C</au><au>Silva, Vanessa Dos S</au><au>Zufelato, Nicholas</au><au>Bakuzis, Andris F</au><au>Miranda, José Ra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>15</volume><issue>5</issue><spage>511</spage><epage>525</epage><pages>511-525</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys.
We used the ACB to detect the MNP kidney perfusion
. Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution.
We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved.
This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>32077357</pmid><doi>10.2217/nnm-2019-0300</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-5163-8280</orcidid></addata></record> |
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| subjects | Animals biomagnetism chronic kidney disease Contrast agents Creatinine doxorubicin Health care Kidney diseases Kidneys magnetic nanoparticles Magnetic resonance imaging Metabolism nanomedicine Nanoparticles Physiology renal perfusion Scintigraphy Sensors Software Urine |
| title | AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats |
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