Exposure to Metalaxyl Disturbs the Skeletal Development of Zebrafish Embryos
Metalaxyl is broadly applied in agriculture to control peronosporales-caused diseases in plant. To investigate the toxic effects, zebrafish embryos were exposed to metalaxyl at 5, 50 and 500 ng/L for 72 h, the development of larvae were assessed. A significant decreased survival rate, body length, h...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 2020-04, Vol.104 (4), p.432-437 |
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| creator | Wu, Yuqiong Xu, Zhenyi Xu, Xiaobin Fan, Li Jiang, Xianbiao |
| description | Metalaxyl is broadly applied in agriculture to control peronosporales-caused diseases in plant. To investigate the toxic effects, zebrafish embryos were exposed to metalaxyl at 5, 50 and 500 ng/L for 72 h, the development of larvae were assessed. A significant decreased survival rate, body length, hatching rate (48 h post-fertilization), and a significant increased spinal curvature rate were observed in the 500 ng/L treatment. The lengths of lower jaw, upper jaw and hyomandibular were significantly decreased in the 5, 50 and 500 ng/L groups; while the lower jaw width was significantly increased in the 500 ng/L group. The lengths of palatoquadrate, ceratohyal and ethmoid plate were reduced. Though
cyp26a1
mRNA levels showed no significant change, the transcription of
bmp2b
(in the 500 ng/L group),
ihh
(in the 50 and 500 ng/L groups),
shh
(in the 5, 50 and 500 ng/L groups) were significantly up-regulated, which may be related to the abnormal development of the skeleton. |
| doi_str_mv | 10.1007/s00128-020-02806-z |
| format | Article |
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cyp26a1
mRNA levels showed no significant change, the transcription of
bmp2b
(in the 500 ng/L group),
ihh
(in the 50 and 500 ng/L groups),
shh
(in the 5, 50 and 500 ng/L groups) were significantly up-regulated, which may be related to the abnormal development of the skeleton.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s00128-020-02806-z</identifier><identifier>PMID: 32072197</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alanine - analogs & derivatives ; Alanine - toxicity ; Animals ; Aquatic Pollution ; Body length ; Bone and Bones - drug effects ; Bone and Bones - embryology ; Dose-Response Relationship, Drug ; Earth and Environmental Science ; Ecotoxicology ; Embryo, Nonmammalian - drug effects ; Embryonic Development - drug effects ; Embryos ; Environment ; Environmental Chemistry ; Environmental Health ; Fertilization ; Fungicides ; Hatching ; Jaw ; Larva - drug effects ; Larva - growth & development ; Larvae ; Mandible ; Maxilla ; Metalaxyl ; Plant diseases ; Pollution ; Skeleton ; Soil Science & Conservation ; Spinal curvature ; Survival ; Transcription ; Waste Water Technology ; Water Management ; Water Pollutants, Chemical - toxicity ; Water Pollution Control ; Zebrafish</subject><ispartof>Bulletin of environmental contamination and toxicology, 2020-04, Vol.104 (4), p.432-437</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-dba1e845aefd09ae0420593e181c2616bc268268f23014f732402c01441677833</citedby><cites>FETCH-LOGICAL-c375t-dba1e845aefd09ae0420593e181c2616bc268268f23014f732402c01441677833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00128-020-02806-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00128-020-02806-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32072197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Yuqiong</creatorcontrib><creatorcontrib>Xu, Zhenyi</creatorcontrib><creatorcontrib>Xu, Xiaobin</creatorcontrib><creatorcontrib>Fan, Li</creatorcontrib><creatorcontrib>Jiang, Xianbiao</creatorcontrib><title>Exposure to Metalaxyl Disturbs the Skeletal Development of Zebrafish Embryos</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><addtitle>Bull Environ Contam Toxicol</addtitle><description>Metalaxyl is broadly applied in agriculture to control peronosporales-caused diseases in plant. To investigate the toxic effects, zebrafish embryos were exposed to metalaxyl at 5, 50 and 500 ng/L for 72 h, the development of larvae were assessed. A significant decreased survival rate, body length, hatching rate (48 h post-fertilization), and a significant increased spinal curvature rate were observed in the 500 ng/L treatment. The lengths of lower jaw, upper jaw and hyomandibular were significantly decreased in the 5, 50 and 500 ng/L groups; while the lower jaw width was significantly increased in the 500 ng/L group. The lengths of palatoquadrate, ceratohyal and ethmoid plate were reduced. Though
cyp26a1
mRNA levels showed no significant change, the transcription of
bmp2b
(in the 500 ng/L group),
ihh
(in the 50 and 500 ng/L groups),
shh
(in the 5, 50 and 500 ng/L groups) were significantly up-regulated, which may be related to the abnormal development of the skeleton.</description><subject>Alanine - analogs & derivatives</subject><subject>Alanine - toxicity</subject><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Body length</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - embryology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Embryo, Nonmammalian - drug effects</subject><subject>Embryonic Development - drug effects</subject><subject>Embryos</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Fertilization</subject><subject>Fungicides</subject><subject>Hatching</subject><subject>Jaw</subject><subject>Larva - drug effects</subject><subject>Larva - growth & development</subject><subject>Larvae</subject><subject>Mandible</subject><subject>Maxilla</subject><subject>Metalaxyl</subject><subject>Plant diseases</subject><subject>Pollution</subject><subject>Skeleton</subject><subject>Soil Science & Conservation</subject><subject>Spinal curvature</subject><subject>Survival</subject><subject>Transcription</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - 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analogs & derivatives</topic><topic>Alanine - toxicity</topic><topic>Animals</topic><topic>Aquatic Pollution</topic><topic>Body length</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - embryology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Embryo, Nonmammalian - drug effects</topic><topic>Embryonic Development - drug effects</topic><topic>Embryos</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Fertilization</topic><topic>Fungicides</topic><topic>Hatching</topic><topic>Jaw</topic><topic>Larva - drug effects</topic><topic>Larva - growth & development</topic><topic>Larvae</topic><topic>Mandible</topic><topic>Maxilla</topic><topic>Metalaxyl</topic><topic>Plant diseases</topic><topic>Pollution</topic><topic>Skeleton</topic><topic>Soil Science & Conservation</topic><topic>Spinal curvature</topic><topic>Survival</topic><topic>Transcription</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollutants, Chemical - 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Academic</collection><jtitle>Bulletin of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yuqiong</au><au>Xu, Zhenyi</au><au>Xu, Xiaobin</au><au>Fan, Li</au><au>Jiang, Xianbiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to Metalaxyl Disturbs the Skeletal Development of Zebrafish Embryos</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><stitle>Bull Environ Contam Toxicol</stitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>104</volume><issue>4</issue><spage>432</spage><epage>437</epage><pages>432-437</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><abstract>Metalaxyl is broadly applied in agriculture to control peronosporales-caused diseases in plant. To investigate the toxic effects, zebrafish embryos were exposed to metalaxyl at 5, 50 and 500 ng/L for 72 h, the development of larvae were assessed. A significant decreased survival rate, body length, hatching rate (48 h post-fertilization), and a significant increased spinal curvature rate were observed in the 500 ng/L treatment. The lengths of lower jaw, upper jaw and hyomandibular were significantly decreased in the 5, 50 and 500 ng/L groups; while the lower jaw width was significantly increased in the 500 ng/L group. The lengths of palatoquadrate, ceratohyal and ethmoid plate were reduced. Though
cyp26a1
mRNA levels showed no significant change, the transcription of
bmp2b
(in the 500 ng/L group),
ihh
(in the 50 and 500 ng/L groups),
shh
(in the 5, 50 and 500 ng/L groups) were significantly up-regulated, which may be related to the abnormal development of the skeleton.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32072197</pmid><doi>10.1007/s00128-020-02806-z</doi><tpages>6</tpages></addata></record> |
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| ispartof | Bulletin of environmental contamination and toxicology, 2020-04, Vol.104 (4), p.432-437 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Alanine - analogs & derivatives Alanine - toxicity Animals Aquatic Pollution Body length Bone and Bones - drug effects Bone and Bones - embryology Dose-Response Relationship, Drug Earth and Environmental Science Ecotoxicology Embryo, Nonmammalian - drug effects Embryonic Development - drug effects Embryos Environment Environmental Chemistry Environmental Health Fertilization Fungicides Hatching Jaw Larva - drug effects Larva - growth & development Larvae Mandible Maxilla Metalaxyl Plant diseases Pollution Skeleton Soil Science & Conservation Spinal curvature Survival Transcription Waste Water Technology Water Management Water Pollutants, Chemical - toxicity Water Pollution Control Zebrafish |
| title | Exposure to Metalaxyl Disturbs the Skeletal Development of Zebrafish Embryos |
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