A copper-mediated on-off-on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition
The sensitive and selective detection of endogenous glutathione (GSH) is of great significance due to its key role in physiological and pathological processes. Herein, we report a novel on-off-on transferrin (Tf)-coated gold nanocluster (AuNCs@Tf) with low toxicity, good stability and intense red fl...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-04, Vol.7 (13), p.2169-2176 |
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| container_issue | 13 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Zhao, Hemiao Wen, Xiangping Li, Wenyan Li, Yingqi Yin, Caixia |
| description | The sensitive and selective detection of endogenous glutathione (GSH) is of great significance due to its key role in physiological and pathological processes. Herein, we report a novel on-off-on transferrin (Tf)-coated gold nanocluster (AuNCs@Tf) with low toxicity, good stability and intense red fluorescence which can enter living cells and is mainly located in lysosomes. In addition, the fluorescence of AuNCs@Tf is quenched by Cu
, indicating its sensitivity to Cu
with a detection limit of 0.23 μM at pH 4.5. Interestingly, we found that the quenched AuNCs@Tf-Cu
system only has a special affinity for GSH with a detection limit of 2.86 μM so that invisible AuNCs@Tf-Cu
can be gradually illuminated by endogenous GSH in the lysosomal environment of tumor cells with increase in time. More excitingly, the AuNCs@Tf-Cu
system can illuminate tumor cells rather than normal cells, resulting in its successful application in cancer cell recognition, which implies its great potential application in cancer diagnosis. Moreover, the AuNCs@Tf was also applied in Cu
strips and encryption/decryption of information. |
| doi_str_mv | 10.1039/c8tb03184c |
| format | Article |
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, indicating its sensitivity to Cu
with a detection limit of 0.23 μM at pH 4.5. Interestingly, we found that the quenched AuNCs@Tf-Cu
system only has a special affinity for GSH with a detection limit of 2.86 μM so that invisible AuNCs@Tf-Cu
can be gradually illuminated by endogenous GSH in the lysosomal environment of tumor cells with increase in time. More excitingly, the AuNCs@Tf-Cu
system can illuminate tumor cells rather than normal cells, resulting in its successful application in cancer cell recognition, which implies its great potential application in cancer diagnosis. Moreover, the AuNCs@Tf was also applied in Cu
strips and encryption/decryption of information.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c8tb03184c</identifier><identifier>PMID: 32073576</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Cancer ; Cell recognition ; Copper ; Encryption ; Fluorescence ; Glutathione ; Gold ; Lysosomes ; Nanoclusters ; Quenching ; Recognition ; Toxicity ; Transferrin ; Tumor cells ; Tumors</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2019-04, Vol.7 (13), p.2169-2176</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-441760f0c00ffd74dcdc34908faafbbccd1170d4fb8ccb028645f4a7f93fee303</citedby><cites>FETCH-LOGICAL-c315t-441760f0c00ffd74dcdc34908faafbbccd1170d4fb8ccb028645f4a7f93fee303</cites><orcidid>0000-0001-5548-6333 ; 0000-0002-0018-0684</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32073576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Hemiao</creatorcontrib><creatorcontrib>Wen, Xiangping</creatorcontrib><creatorcontrib>Li, Wenyan</creatorcontrib><creatorcontrib>Li, Yingqi</creatorcontrib><creatorcontrib>Yin, Caixia</creatorcontrib><title>A copper-mediated on-off-on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>The sensitive and selective detection of endogenous glutathione (GSH) is of great significance due to its key role in physiological and pathological processes. Herein, we report a novel on-off-on transferrin (Tf)-coated gold nanocluster (AuNCs@Tf) with low toxicity, good stability and intense red fluorescence which can enter living cells and is mainly located in lysosomes. In addition, the fluorescence of AuNCs@Tf is quenched by Cu
, indicating its sensitivity to Cu
with a detection limit of 0.23 μM at pH 4.5. Interestingly, we found that the quenched AuNCs@Tf-Cu
system only has a special affinity for GSH with a detection limit of 2.86 μM so that invisible AuNCs@Tf-Cu
can be gradually illuminated by endogenous GSH in the lysosomal environment of tumor cells with increase in time. More excitingly, the AuNCs@Tf-Cu
system can illuminate tumor cells rather than normal cells, resulting in its successful application in cancer cell recognition, which implies its great potential application in cancer diagnosis. Moreover, the AuNCs@Tf was also applied in Cu
strips and encryption/decryption of information.</description><subject>Cancer</subject><subject>Cell recognition</subject><subject>Copper</subject><subject>Encryption</subject><subject>Fluorescence</subject><subject>Glutathione</subject><subject>Gold</subject><subject>Lysosomes</subject><subject>Nanoclusters</subject><subject>Quenching</subject><subject>Recognition</subject><subject>Toxicity</subject><subject>Transferrin</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkUFLAzEUhIMotlQv_gAJeBFh9WWTbdJjLdoKggcVvC3Zl6Ru2SY12RX892619uC7zDt8DMMMIWcMrhnwyQ2qtgLOlMADMsyhgEwWTB3uf3gbkNOUVtCfYmPFxTEZ8BwkL-R4SN6nFMNmY2O2tqbWrTU0-Cw4lwVPl6Ex1GsfsOlSayN1IVLrTVhaH7pE588LmqxPtV_SNlAT609LUXvsUbRNQ6PFsPR1Wwd_Qo6cbpI93emIvN7fvcwW2ePT_GE2fcyQs6LNhGByDA4QwDkjhUGDXExAOa1dVSEaxiQY4SqFWEGuxqJwQks34c5aDnxELn99NzF8dDa15bpO2zDa2z5zmfNCFZIDUz168Q9dhS76Pl2Zs4nikEvYGl79UhhDStG6chPrtY5fJYNyO0E5Uy-3PxPMevh8Z9lVfaF79K9w_g0bA4GS</recordid><startdate>20190407</startdate><enddate>20190407</enddate><creator>Zhao, Hemiao</creator><creator>Wen, Xiangping</creator><creator>Li, Wenyan</creator><creator>Li, Yingqi</creator><creator>Yin, Caixia</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5548-6333</orcidid><orcidid>https://orcid.org/0000-0002-0018-0684</orcidid></search><sort><creationdate>20190407</creationdate><title>A copper-mediated on-off-on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition</title><author>Zhao, Hemiao ; Wen, Xiangping ; Li, Wenyan ; Li, Yingqi ; Yin, Caixia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-441760f0c00ffd74dcdc34908faafbbccd1170d4fb8ccb028645f4a7f93fee303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cancer</topic><topic>Cell recognition</topic><topic>Copper</topic><topic>Encryption</topic><topic>Fluorescence</topic><topic>Glutathione</topic><topic>Gold</topic><topic>Lysosomes</topic><topic>Nanoclusters</topic><topic>Quenching</topic><topic>Recognition</topic><topic>Toxicity</topic><topic>Transferrin</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Hemiao</creatorcontrib><creatorcontrib>Wen, Xiangping</creatorcontrib><creatorcontrib>Li, Wenyan</creatorcontrib><creatorcontrib>Li, Yingqi</creatorcontrib><creatorcontrib>Yin, Caixia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Hemiao</au><au>Wen, Xiangping</au><au>Li, Wenyan</au><au>Li, Yingqi</au><au>Yin, Caixia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A copper-mediated on-off-on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2019-04-07</date><risdate>2019</risdate><volume>7</volume><issue>13</issue><spage>2169</spage><epage>2176</epage><pages>2169-2176</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>The sensitive and selective detection of endogenous glutathione (GSH) is of great significance due to its key role in physiological and pathological processes. Herein, we report a novel on-off-on transferrin (Tf)-coated gold nanocluster (AuNCs@Tf) with low toxicity, good stability and intense red fluorescence which can enter living cells and is mainly located in lysosomes. In addition, the fluorescence of AuNCs@Tf is quenched by Cu
, indicating its sensitivity to Cu
with a detection limit of 0.23 μM at pH 4.5. Interestingly, we found that the quenched AuNCs@Tf-Cu
system only has a special affinity for GSH with a detection limit of 2.86 μM so that invisible AuNCs@Tf-Cu
can be gradually illuminated by endogenous GSH in the lysosomal environment of tumor cells with increase in time. More excitingly, the AuNCs@Tf-Cu
system can illuminate tumor cells rather than normal cells, resulting in its successful application in cancer cell recognition, which implies its great potential application in cancer diagnosis. Moreover, the AuNCs@Tf was also applied in Cu
strips and encryption/decryption of information.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32073576</pmid><doi>10.1039/c8tb03184c</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5548-6333</orcidid><orcidid>https://orcid.org/0000-0002-0018-0684</orcidid></addata></record> |
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| source | Royal Society Of Chemistry Journals |
| subjects | Cancer Cell recognition Copper Encryption Fluorescence Glutathione Gold Lysosomes Nanoclusters Quenching Recognition Toxicity Transferrin Tumor cells Tumors |
| title | A copper-mediated on-off-on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition |
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