Phospholipase D as a key modulator of cancer progression
ABSTRACT The phospholipase D (PLD) family has a ubiquitous expression in cells. PLD isoforms (PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in multiple stages of cancer progression. Aberrant expression of PLDs, especially PLD1 and PLD2, has been detected in vari...
Gespeichert in:
| Veröffentlicht in: | Biological reviews of the Cambridge Philosophical Society 2020-08, Vol.95 (4), p.911-935 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 935 |
|---|---|
| container_issue | 4 |
| container_start_page | 911 |
| container_title | Biological reviews of the Cambridge Philosophical Society |
| container_volume | 95 |
| creator | Yao, Yuanfa Wang, Xinyi Li, Hanbing Fan, Jiannan Qian, Xiaohan Li, Hong Xu, Yingke |
| description | ABSTRACT
The phospholipase D (PLD) family has a ubiquitous expression in cells. PLD isoforms (PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in multiple stages of cancer progression. Aberrant expression of PLDs, especially PLD1 and PLD2, has been detected in various cancers. Inhibition or elimination of PLDs activity has been shown to reduce tumour growth and metastasis. PLDs and PA also serve as downstream effectors of various cell‐surface receptors, to trigger and regulate propagation of intracellular signals in the process of tumourigenesis and metastasis. Here, we discuss recent advances in understanding the functions of PLDs and PA in discrete stages of cancer progression, including cancer cell growth, invasion and migration, and angiogenesis, with special emphasis on the tumour‐associated signalling pathways mediated by PLDs and PA and the functional importance of PLDs and PA in cancer therapy. |
| doi_str_mv | 10.1111/brv.12592 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2358572966</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2420025697</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-a671b57d58ff0904e26448ced752089267850c60d175dede011718686512256b3</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EoqWw4AeQJTawSOtH_MgSylOqBEKA2FlO4tCUJA52A-rfY5rCAglvxhodnZm5ABxiNMbhTVL3McaEJWQLDHHMkwhL9rK9_seRSCgegD3vFwiFBqe7YEAJEpRgPgTyfm59O7dV2Wpv4AXUHmr4ZlawtnlX6aV10BYw001mHGydfXXG-9I2-2Cn0JU3B5s6Ak9Xl4_Tm2h2d307PZtFGWWURJoLnDKRM1kUKEGxITyOZWZywQiSCeFCMpRxlGPBcpMbhLHAkkvOMCGMp3QETnpvmP3eGb9UdekzU1W6MbbzilAmmSBJOGwEjv-gC9u5JmynSEwQCr5EBOq0pzJnvXemUK0ra-1WCiP1HacKcap1nIE92hi7tDb5L_mTXwAmPfBZVmb1v0mdPzz3yi--THtK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2420025697</pqid></control><display><type>article</type><title>Phospholipase D as a key modulator of cancer progression</title><source>Wiley Online Library All Journals</source><creator>Yao, Yuanfa ; Wang, Xinyi ; Li, Hanbing ; Fan, Jiannan ; Qian, Xiaohan ; Li, Hong ; Xu, Yingke</creator><creatorcontrib>Yao, Yuanfa ; Wang, Xinyi ; Li, Hanbing ; Fan, Jiannan ; Qian, Xiaohan ; Li, Hong ; Xu, Yingke</creatorcontrib><description>ABSTRACT
The phospholipase D (PLD) family has a ubiquitous expression in cells. PLD isoforms (PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in multiple stages of cancer progression. Aberrant expression of PLDs, especially PLD1 and PLD2, has been detected in various cancers. Inhibition or elimination of PLDs activity has been shown to reduce tumour growth and metastasis. PLDs and PA also serve as downstream effectors of various cell‐surface receptors, to trigger and regulate propagation of intracellular signals in the process of tumourigenesis and metastasis. Here, we discuss recent advances in understanding the functions of PLDs and PA in discrete stages of cancer progression, including cancer cell growth, invasion and migration, and angiogenesis, with special emphasis on the tumour‐associated signalling pathways mediated by PLDs and PA and the functional importance of PLDs and PA in cancer therapy.</description><identifier>ISSN: 1464-7931</identifier><identifier>EISSN: 1469-185X</identifier><identifier>DOI: 10.1111/brv.12592</identifier><identifier>PMID: 32073216</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Angiogenesis ; Cancer ; Cell migration ; Cell surface ; Isoforms ; Metastases ; Metastasis ; Phosphatidic acid ; Phospholipase ; Phospholipase D ; Signal processing ; Signal transduction ; signalling transduction ; Tumorigenesis ; Tumors ; tumourigenesis</subject><ispartof>Biological reviews of the Cambridge Philosophical Society, 2020-08, Vol.95 (4), p.911-935</ispartof><rights>2020 Cambridge Philosophical Society</rights><rights>2020 Cambridge Philosophical Society.</rights><rights>Biological Reviews © 2020 Cambridge Philosophical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-a671b57d58ff0904e26448ced752089267850c60d175dede011718686512256b3</citedby><cites>FETCH-LOGICAL-c3532-a671b57d58ff0904e26448ced752089267850c60d175dede011718686512256b3</cites><orcidid>0000-0003-3873-4061 ; 0000-0002-4256-9321 ; 0000-0003-4158-1860 ; 0000-0002-6926-5934 ; 0000-0002-8317-0608 ; 0000-0003-0110-8817 ; 0000-0002-6392-8493</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbrv.12592$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbrv.12592$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32073216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Yuanfa</creatorcontrib><creatorcontrib>Wang, Xinyi</creatorcontrib><creatorcontrib>Li, Hanbing</creatorcontrib><creatorcontrib>Fan, Jiannan</creatorcontrib><creatorcontrib>Qian, Xiaohan</creatorcontrib><creatorcontrib>Li, Hong</creatorcontrib><creatorcontrib>Xu, Yingke</creatorcontrib><title>Phospholipase D as a key modulator of cancer progression</title><title>Biological reviews of the Cambridge Philosophical Society</title><addtitle>Biol Rev Camb Philos Soc</addtitle><description>ABSTRACT
The phospholipase D (PLD) family has a ubiquitous expression in cells. PLD isoforms (PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in multiple stages of cancer progression. Aberrant expression of PLDs, especially PLD1 and PLD2, has been detected in various cancers. Inhibition or elimination of PLDs activity has been shown to reduce tumour growth and metastasis. PLDs and PA also serve as downstream effectors of various cell‐surface receptors, to trigger and regulate propagation of intracellular signals in the process of tumourigenesis and metastasis. Here, we discuss recent advances in understanding the functions of PLDs and PA in discrete stages of cancer progression, including cancer cell growth, invasion and migration, and angiogenesis, with special emphasis on the tumour‐associated signalling pathways mediated by PLDs and PA and the functional importance of PLDs and PA in cancer therapy.</description><subject>Angiogenesis</subject><subject>Cancer</subject><subject>Cell migration</subject><subject>Cell surface</subject><subject>Isoforms</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Phosphatidic acid</subject><subject>Phospholipase</subject><subject>Phospholipase D</subject><subject>Signal processing</subject><subject>Signal transduction</subject><subject>signalling transduction</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><subject>tumourigenesis</subject><issn>1464-7931</issn><issn>1469-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EoqWw4AeQJTawSOtH_MgSylOqBEKA2FlO4tCUJA52A-rfY5rCAglvxhodnZm5ABxiNMbhTVL3McaEJWQLDHHMkwhL9rK9_seRSCgegD3vFwiFBqe7YEAJEpRgPgTyfm59O7dV2Wpv4AXUHmr4ZlawtnlX6aV10BYw001mHGydfXXG-9I2-2Cn0JU3B5s6Ak9Xl4_Tm2h2d307PZtFGWWURJoLnDKRM1kUKEGxITyOZWZywQiSCeFCMpRxlGPBcpMbhLHAkkvOMCGMp3QETnpvmP3eGb9UdekzU1W6MbbzilAmmSBJOGwEjv-gC9u5JmynSEwQCr5EBOq0pzJnvXemUK0ra-1WCiP1HacKcap1nIE92hi7tDb5L_mTXwAmPfBZVmb1v0mdPzz3yi--THtK</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Yao, Yuanfa</creator><creator>Wang, Xinyi</creator><creator>Li, Hanbing</creator><creator>Fan, Jiannan</creator><creator>Qian, Xiaohan</creator><creator>Li, Hong</creator><creator>Xu, Yingke</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SN</scope><scope>7SS</scope><scope>C1K</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3873-4061</orcidid><orcidid>https://orcid.org/0000-0002-4256-9321</orcidid><orcidid>https://orcid.org/0000-0003-4158-1860</orcidid><orcidid>https://orcid.org/0000-0002-6926-5934</orcidid><orcidid>https://orcid.org/0000-0002-8317-0608</orcidid><orcidid>https://orcid.org/0000-0003-0110-8817</orcidid><orcidid>https://orcid.org/0000-0002-6392-8493</orcidid></search><sort><creationdate>202008</creationdate><title>Phospholipase D as a key modulator of cancer progression</title><author>Yao, Yuanfa ; Wang, Xinyi ; Li, Hanbing ; Fan, Jiannan ; Qian, Xiaohan ; Li, Hong ; Xu, Yingke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-a671b57d58ff0904e26448ced752089267850c60d175dede011718686512256b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angiogenesis</topic><topic>Cancer</topic><topic>Cell migration</topic><topic>Cell surface</topic><topic>Isoforms</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Phosphatidic acid</topic><topic>Phospholipase</topic><topic>Phospholipase D</topic><topic>Signal processing</topic><topic>Signal transduction</topic><topic>signalling transduction</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><topic>tumourigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Yuanfa</creatorcontrib><creatorcontrib>Wang, Xinyi</creatorcontrib><creatorcontrib>Li, Hanbing</creatorcontrib><creatorcontrib>Fan, Jiannan</creatorcontrib><creatorcontrib>Qian, Xiaohan</creatorcontrib><creatorcontrib>Li, Hong</creatorcontrib><creatorcontrib>Xu, Yingke</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Biological reviews of the Cambridge Philosophical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Yuanfa</au><au>Wang, Xinyi</au><au>Li, Hanbing</au><au>Fan, Jiannan</au><au>Qian, Xiaohan</au><au>Li, Hong</au><au>Xu, Yingke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phospholipase D as a key modulator of cancer progression</atitle><jtitle>Biological reviews of the Cambridge Philosophical Society</jtitle><addtitle>Biol Rev Camb Philos Soc</addtitle><date>2020-08</date><risdate>2020</risdate><volume>95</volume><issue>4</issue><spage>911</spage><epage>935</epage><pages>911-935</pages><issn>1464-7931</issn><eissn>1469-185X</eissn><abstract>ABSTRACT
The phospholipase D (PLD) family has a ubiquitous expression in cells. PLD isoforms (PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in multiple stages of cancer progression. Aberrant expression of PLDs, especially PLD1 and PLD2, has been detected in various cancers. Inhibition or elimination of PLDs activity has been shown to reduce tumour growth and metastasis. PLDs and PA also serve as downstream effectors of various cell‐surface receptors, to trigger and regulate propagation of intracellular signals in the process of tumourigenesis and metastasis. Here, we discuss recent advances in understanding the functions of PLDs and PA in discrete stages of cancer progression, including cancer cell growth, invasion and migration, and angiogenesis, with special emphasis on the tumour‐associated signalling pathways mediated by PLDs and PA and the functional importance of PLDs and PA in cancer therapy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>32073216</pmid><doi>10.1111/brv.12592</doi><tpages>25</tpages><orcidid>https://orcid.org/0000-0003-3873-4061</orcidid><orcidid>https://orcid.org/0000-0002-4256-9321</orcidid><orcidid>https://orcid.org/0000-0003-4158-1860</orcidid><orcidid>https://orcid.org/0000-0002-6926-5934</orcidid><orcidid>https://orcid.org/0000-0002-8317-0608</orcidid><orcidid>https://orcid.org/0000-0003-0110-8817</orcidid><orcidid>https://orcid.org/0000-0002-6392-8493</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1464-7931 |
| ispartof | Biological reviews of the Cambridge Philosophical Society, 2020-08, Vol.95 (4), p.911-935 |
| issn | 1464-7931 1469-185X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2358572966 |
| source | Wiley Online Library All Journals |
| subjects | Angiogenesis Cancer Cell migration Cell surface Isoforms Metastases Metastasis Phosphatidic acid Phospholipase Phospholipase D Signal processing Signal transduction signalling transduction Tumorigenesis Tumors tumourigenesis |
| title | Phospholipase D as a key modulator of cancer progression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T11%3A35%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phospholipase%20D%20as%20a%20key%20modulator%20of%20cancer%20progression&rft.jtitle=Biological%20reviews%20of%20the%20Cambridge%20Philosophical%20Society&rft.au=Yao,%20Yuanfa&rft.date=2020-08&rft.volume=95&rft.issue=4&rft.spage=911&rft.epage=935&rft.pages=911-935&rft.issn=1464-7931&rft.eissn=1469-185X&rft_id=info:doi/10.1111/brv.12592&rft_dat=%3Cproquest_cross%3E2420025697%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2420025697&rft_id=info:pmid/32073216&rfr_iscdi=true |