MicroRNAs in gray and white matter multiple sclerosis lesions: impact on pathophysiology
Multiple sclerosis (MS) is a chronic disease of the CNS, hallmarked by inflammation and demyelination. Early stages of the disease frequently show active lesions containing numerous foamy macrophages and inflammatory cells. Disease progression is highlighted by increasing numbers of mixed active/ina...
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| Veröffentlicht in: | The Journal of pathology 2020-04, Vol.250 (5), p.496-509 |
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| creator | Teuber‐Hanselmann, Sarah Meinl, Edgar Junker, Andreas |
| description | Multiple sclerosis (MS) is a chronic disease of the CNS, hallmarked by inflammation and demyelination. Early stages of the disease frequently show active lesions containing numerous foamy macrophages and inflammatory cells. Disease progression is highlighted by increasing numbers of mixed active/inactive or inactive lesions showing sparse inflammation and pronounced astrogliosis. Furthermore, gray matter lesions increase in number and extent during disease progression. MicroRNAs (miRNAs) comprise a group of several thousand (in humans more than 2000), small non‐coding RNA molecules with a fundamental influence on about one‐third of all protein‐coding genes. Furthermore, miRNAs have been detected in body fluids, including spinal fluid, and they are assumed to participate in intercellular communications. Several studies have determined miRNA profiles from dissected white and gray matter lesions of autoptic MS patients. In this review, we summarize in detail the current knowledge of individual miRNAs in gray and white matter lesions of MS patients and present the concepts of MS tissue lesion development based on the altered miRNA profiles. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. |
| doi_str_mv | 10.1002/path.5399 |
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Early stages of the disease frequently show active lesions containing numerous foamy macrophages and inflammatory cells. Disease progression is highlighted by increasing numbers of mixed active/inactive or inactive lesions showing sparse inflammation and pronounced astrogliosis. Furthermore, gray matter lesions increase in number and extent during disease progression. MicroRNAs (miRNAs) comprise a group of several thousand (in humans more than 2000), small non‐coding RNA molecules with a fundamental influence on about one‐third of all protein‐coding genes. Furthermore, miRNAs have been detected in body fluids, including spinal fluid, and they are assumed to participate in intercellular communications. Several studies have determined miRNA profiles from dissected white and gray matter lesions of autoptic MS patients. In this review, we summarize in detail the current knowledge of individual miRNAs in gray and white matter lesions of MS patients and present the concepts of MS tissue lesion development based on the altered miRNA profiles. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.5399</identifier><identifier>PMID: 32073139</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Body fluids ; Cerebrospinal fluid ; Chronic illnesses ; chronic inactive lesions ; demyelinated lesions ; Demyelination ; Gliosis ; gray matter lesions ; inflammatory lesions ; Lesions ; Macrophages ; MicroRNAs ; miRNA ; Multiple sclerosis ; Non-coding RNA ; Substantia alba ; Substantia grisea ; white matter lesions</subject><ispartof>The Journal of pathology, 2020-04, Vol.250 (5), p.496-509</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.</rights><rights>2020 The Authors. 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In this review, we summarize in detail the current knowledge of individual miRNAs in gray and white matter lesions of MS patients and present the concepts of MS tissue lesion development based on the altered miRNA profiles. © 2020 The Authors. 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| source | Wiley-Blackwell Journals |
| subjects | Body fluids Cerebrospinal fluid Chronic illnesses chronic inactive lesions demyelinated lesions Demyelination Gliosis gray matter lesions inflammatory lesions Lesions Macrophages MicroRNAs miRNA Multiple sclerosis Non-coding RNA Substantia alba Substantia grisea white matter lesions |
| title | MicroRNAs in gray and white matter multiple sclerosis lesions: impact on pathophysiology |
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