Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations
Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage t...
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| Veröffentlicht in: | Pediatrics (Evanston) 2020-03, Vol.145 (3), p.1 |
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| container_title | Pediatrics (Evanston) |
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| creator | Klipstein, Sigal Fallat, Mary E Savelli, Stephanie |
| description | Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer. |
| doi_str_mv | 10.1542/peds.2019-3994 |
| format | Article |
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Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2019-3994</identifier><identifier>PMID: 32071259</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Adolescent ; Antineoplastic Agents - adverse effects ; Cancer ; Cancer Survivors ; Chemotherapy ; Child ; Counseling ; Cryopreservation ; Ethics ; Fertility ; Fertility Preservation - ethics ; Germ cells ; Humans ; Hypothalamus ; Infertility ; Infertility - etiology ; Insurance Coverage ; Insurance, Health ; Male ; Medical ethics ; Neoplasms - therapy ; Oocytes - cytology ; Patients ; Pediatrics ; Pituitary ; Preservation ; Radiation therapy ; Radiotherapy - adverse effects ; Reproductive technologies ; Reproductive technology ; Solid tumors ; Spermatozoa ; Sterility ; Surgery ; Teenagers ; Uterus</subject><ispartof>Pediatrics (Evanston), 2020-03, Vol.145 (3), p.1</ispartof><rights>Copyright © 2020 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Mar 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-4506bfe6f48cd7ce12ef7d5c42508279f09871cdd86c14d95289e678d0490f763</citedby><cites>FETCH-LOGICAL-c363t-4506bfe6f48cd7ce12ef7d5c42508279f09871cdd86c14d95289e678d0490f763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32071259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klipstein, Sigal</creatorcontrib><creatorcontrib>Fallat, Mary E</creatorcontrib><creatorcontrib>Savelli, Stephanie</creatorcontrib><creatorcontrib>SECTION ON HEMATOLOGY/ONCOLOGY</creatorcontrib><creatorcontrib>SECTION ON SURGERY</creatorcontrib><creatorcontrib>COMMITTEE ON BIOETHICS</creatorcontrib><creatorcontrib>SECTION ON SURGERY</creatorcontrib><creatorcontrib>SECTION ON HEMATOLOGY/ONCOLOGY</creatorcontrib><creatorcontrib>COMMITTEE ON BIOETHICS</creatorcontrib><title>Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Antineoplastic Agents - adverse effects Cancer Cancer Survivors Chemotherapy Child Counseling Cryopreservation Ethics Fertility Fertility Preservation - ethics Germ cells Humans Hypothalamus Infertility Infertility - etiology Insurance Coverage Insurance, Health Male Medical ethics Neoplasms - therapy Oocytes - cytology Patients Pediatrics Pituitary Preservation Radiation therapy Radiotherapy - adverse effects Reproductive technologies Reproductive technology Solid tumors Spermatozoa Sterility Surgery Teenagers Uterus |
| title | Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations |
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