Microstructural Bone Changes Are Associated With Broad‐Spectrum Autoimmunity and Predict the Onset of Rheumatoid Arthritis

Objective To assess if microstructural bone lesions in individuals at risk of developing rheumatoid arthritis (RA) are related to the spectrum of anti–modified protein antibodies (AMPAs) and affect the risk of developing RA. Methods Cortical microchannels as well as cortical and trabecular bone mine...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2022-03, Vol.74 (3), p.418-426
Hauptverfasser:	Simon, David, Kleyer, Arnd, Cong, Duy Bui, Hueber, Axel, Bang, Holger, Ramming, Andreas, Rech, Juergen, Schett, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Arthritis Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - immunology Autoimmune diseases Autoimmunity Biomedical materials Bone Density - physiology Bone lesions Bone mineral density Cancellous bone Cancellous Bone - diagnostic imaging Citrulline Computed tomography Cortical bone Cortical Bone - diagnostic imaging Cross-Sectional Studies Female Fibrinogen Hand Joints - diagnostic imaging Humans Hydroxyapatite Joint diseases Joints (anatomy) Longitudinal Studies Male Microchannels Middle Aged Phosphopyruvate hydratase Priming Proteins Reactivity Rheumatoid arthritis Risk Tomography, X-Ray Computed Vimentin
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