Perineural application of resiniferatoxin on uninjured L3 and L4 nerves completely alleviates thermal and mechanical hypersensitivity following L5 nerve injury in rats

Fifth lumbar (L5) nerve injury in rats causes neuropathic pain manifested with thermal and mechanical hypersensitivity in the ipsilateral hind paw. This study aimed to determine whether the elimination of unmyelinated primary afferents of the adjacent uninjured nerves (L3 and L4) would alleviate per...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of comparative neurology (1911) 2020-09, Vol.528 (13), p.2195-2217
Hauptverfasser:	Javed, Hayate, Rehmathulla, Sumisha, Tariq, Saeed, Emerald, Bright S., Ljubisavljevic, Milos, Shehab, Safa
Format:	Artikel
Sprache:	eng
Schlagworte:	AB_1624142 AB_2301751 AB_2314660 AB_2315608 AB_518147 Calcitonin gene-related peptide Capsaicin Capsaicin receptors Chronic pain Dorsal horn Dorsal root ganglia Hypersensitivity Mechanical stimuli neuropathic pain Neuropeptide Y Neuroplasticity Pain Peripheral nerves Peripheral neuropathy rat Resiniferatoxin Rodents Spinal cord Spinal nerves Spinal plasticity TRPV1 uninjured nerve
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!